Effects of neuropeptides implicated in stimulation of feeding behavior on the masticatory rhythm generation in the brainstem
| Project/Area Number |
21390535
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
KOGO Mikihiko 大阪大学, 歯学研究科, 教授 (20205371)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Susumu 大阪大学, 大学院・歯学研究科, 招聘教員 (00367541)
ENOMOTO Akihumi 大阪大学, 大学院・歯学研究科, 招聘教員 (70432549)
TSUJI Tadataka 大阪大学, 歯学部附属病院, 医員 (50527231)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Takashi 畿央大学, 健康科学部, 教授 (60028793)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 摂食行動 / 顎運動 / 脳幹 / オレキシン / 咀嚼筋活動 / 三叉神経運動核 / 三叉神経中脳路核 |
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| Research Abstract |
This study demonstrated that centrally injected orexin (Ox) or neuropeptide Y (NPY), potent stimulants of ingestive behavior, augmented fool intake and facilitated feeding behavior occurring with characteristic changes of EMG activities of masticatory muscles. Whole cell recordings from both trigeminal motoneurons and mesencephalic trigeminal neurons involved in the emergence of masticatory muscle activities revealed excitatory effects of Ox on these neurons by depolarizing membrane potential and increasing action potential frequency in repetitive firing activities. These results suggest that an elevation of intracerebral Ox may has a facilitative role in feeding behavior by regulating excitabilities of trigeminal motor outputs.
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Report
(6 results)
Research Products
(45 results)
