| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Research Abstract |
This study demonstrated that centrally injected orexin (Ox) or neuropeptide Y (NPY), potent stimulants of ingestive behavior, augmented fool intake and facilitated feeding behavior occurring with characteristic changes of EMG activities of masticatory muscles. Whole cell recordings from both trigeminal motoneurons and mesencephalic trigeminal neurons involved in the emergence of masticatory muscle activities revealed excitatory effects of Ox on these neurons by depolarizing membrane potential and increasing action potential frequency in repetitive firing activities. These results suggest that an elevation of intracerebral Ox may has a facilitative role in feeding behavior by regulating excitabilities of trigeminal motor outputs.
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