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Study of oncolytic virotherapy for oral cancer

Research Project

Project/Area Number 21390536
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

YURA Yoshiaki  大阪大学, 大学院・歯学研究科, 教授 (00136277)

Co-Investigator(Renkei-kenkyūsha) IWAI Soichi  大阪大学, 歯学研究科, 助教 (10362675)
HAMADA Hamada  大阪大学, 歯学部附属病院, 医員 (80506361)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords腫瘍融解性ウイルス療法 / ヘルペスウイルス / 組換え体 / 細胞融合 / 遺伝子構造 / 変異型ヘルペスウイルス / 細胞融合能 / 口腔扁平上皮癌 / 超音波照 / ソノポレーション / 腫瘍融解性ウイルス法 / 変異型単純ヘルペスウイルス / 超音波照射 / 口腔肩平上皮癌
Research Abstract

Oncolytic virotherapy has been developed to destroy tumor cells by the cytopathic effect of virus vectors. In the present study, we produced a recombinant herpes simplex virus type 1(HSV-1) RH2 using R849 with LacZ gene at the deleted site of neurovirulentγ_1 34. 5 gene and strain HF with fusogenic ability. Nucleotide sequences of RH2 were determined with Genome Sequencer FLX. RH2 induced large syncytia in squamous cell carcinoma(SCC) cells and was deficient of neurovirulent gene. It can be used as a vector for the treatment of brain tumor as well as oral SCC

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (62 results)

All 2011 2010 2009

All Journal Article (26 results) (of which Peer Reviewed: 20 results) Presentation (33 results) Book (3 results)

  • [Journal Article] Effect of ultrasound on herpes simplex virus infection in cell culture2011

    • Author(s)
      Shintani M, Takahashi G, Hamada M, Okunaga S, Iwai S, Yura Y
    • Journal Title

      Virology Journal

      Volume: 8 Issue: 1 Pages: 446-446

    • DOI

      10.1186/1743-422x-8-446

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinoma2011

    • Author(s)
      Takaoka H, Takahashi G, Ogawa F, Imai T, Iwai S, Yura Y
    • Journal Title

      Virology Journal

      Volume: 8 Issue: 1 Pages: 294-294

    • DOI

      10.1186/1743-422x-8-294

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of multinucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy2011

    • Author(s)
      Fujita Y, Yamamoto N, Kato I, Iwai S, Ono K, Sakurai Y, Ohnishi K, Ohnishi T, Yura Y
    • Journal Title

      International Journal of Radiation Biology

      Volume: 87(3) Pages: 293-301

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells2011

    • Author(s)
      Hamada M, Miki T, Iwai S, Shimizu H, Yura Y
    • Journal Title

      Cancer Chemotherapy and Pharmacology

      Volume: 68(3) Pages: 559-569

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphatic vessels and related factors in adenoid cystic carcinoma of the salivary gland2011

    • Author(s)
      Fujita G
    • Journal Title

      Modern Pathology

      Volume: 24 Pages: 885-891

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔内ウイルス感染の診断と治療2011

    • Author(s)
      由良義明
    • Journal Title

      ENTONI

      Volume: 129 Pages: 55-60

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 超音波がヒト口腔扁平上皮癌細胞へのホウ素化合物取り込みに及ぼす影響2011

    • Author(s)
      山本直典
    • Journal Title

      口腔組織培養学会誌

      Volume: 20 Pages: 33-34

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 変異型単純ヘルペスウイルス1型RH2の腫瘍内増殖能と遺伝子構造に関する研究2011

    • Author(s)
      高橋元
    • Journal Title

      口腔組織培養学会誌

      Volume: 20 Pages: 49-50

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 口腔扁平上皮癌細胞の浸潤能と遊走能におけるWnt-beta-catenin経路の関与2011

    • Author(s)
      岩井聡一
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 57 Pages: 533-541

    • NAID

      10030272853

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of multinucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy.2011

    • Author(s)
      Fujita Y, Yamamoto N, Kato I, Iwai S, Ono K, Sakurai Y, Ohnishi K, Ohnishi T, Yura Y
    • Journal Title

      International Journal of Radiation Biology

      Volume: Vol 87 Pages: 293-230

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RPAP3 enhances cytotoxicity by imparing NF-kappa B pathway.2011

    • Author(s)
      Shimada K, Saeki M, Egusa H, Fukuyasu S, Yura Y, Iwai K, Kamisaki Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: Vol 404 Pages: 910-914

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the Wnt-β-catenin pathway in invasion and migration of oral squamous carcinoma cells2010

    • Author(s)
      Iwai S, Yonekawa A, Harada C, Hamada M, Katagiri W, Nakazawa M, Yura Y
    • Journal Title

      International Journal of Oncology

      Volume: 37(5) Pages: 1095-1103

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the Wnt-β-catenin pathway in invasion and migration of oralsquamous carcinoma cells.2010

    • Author(s)
      Iwai S, Yonekawa A, Harada C, Hamada M, Katagiri W, Nakazawa M, Yura Y
    • Journal Title

      International Journal of Oncology.

      Volume: Vol 37 Pages: 1096-1103

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of RhoA and RalB in geranylgeranyltransferase Iinhibitor-mediated inhibition of proliferation and migration of human oralsquamous cell carcinoma cells.2010

    • Author(s)
      Hamada M, Miki T, Iwai S, Shimizu H, Yura Y
    • Journal Title

      Cancer Chemotherapy Pharmacology

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔癌の分子標的治療に向けたアポトーシス誘導薬の展望2010

    • Author(s)
      濱田正和、野田隆之、岩井聡一、由良義明
    • Journal Title

      口腔組織培養学会誌

      Volume: 19巻 Pages: 37-48

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔粘膜における遅延型アレルギー反応の惹起と組織変化2010

    • Author(s)
      赤垣俊輔、三木哲英、新谷素子、濱田正和、岩井聡一、由良義明
    • Journal Title

      口腔組織培養学会誌

      Volume: 19巻 Pages: 39-40

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ソノポレーションが腫瘍融解性ウイルスの感染に及ぼす影響2010

    • Author(s)
      新谷素子、赤垣俊輔、三木哲英、濱田正和、青田桂子、岩井聡一、由良義明
    • Journal Title

      口腔組織培養学会誌

      Volume: 19巻 Pages: 11-12

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma2009

    • Author(s)
      Fujita Y, Kato I, Iwai S, Ono K, Suzuki M, Sakurai Y, Ohnishi K, Ohnishi T, Yura Y
    • Journal Title

      Radiation Oncology

      Volume: 4(1) Issue: 1 Pages: 63-63

    • DOI

      10.1186/1748-717x-4-63

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol2009

    • Author(s)
      Noda T, Iwai S, Hamada M, Fujita Y, Yura Y
    • Journal Title

      Possible role of Bim, focal adhesion kinase and endonuclease G

      Volume: 14(3) Pages: 287-297

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of trichostatin A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells2009

    • Author(s)
      Katsura T, Iwai S, Ota Y, Shimizu H, Ikuta K, Yura Y
    • Journal Title

      Cancer Gene Therapyc

      Volume: 16(3) Pages: 237-245

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of trichostation A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells.2009

    • Author(s)
      Katsura T, Iwai S, Ota Y, Shimizu H, Ikuta K, Yura Y
    • Journal Title

      Cancer Gene Therapy 16(3)

      Pages: 237-245

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G2009

    • Author(s)
      Noda T, Iwai S, Hamada M, Fujita Y, Yura Y
    • Journal Title

      Apoptosis 14(3)

      Pages: 287-29

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma2009

    • Author(s)
      Fujita Y, Kato I, Iwai S, Ono K, Suzuki M, Sakurai Y, Ohnishi K, Ohnishi T, Yura Y
    • Journal Title

      Radiation Oncology 4(1)

      Pages: 63-63

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regenerative behavior of biomineral/agarose composite gels as bone grafting materials in rat cranial defects.2009

    • Author(s)
      Suzawa Y, Funaki T, Watanabe J, Iwai S, Yura Y, Nakano T, Umakoshi Y, Akashi M
    • Journal Title

      Journal of Biomedical Materials Research, Part A In press

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cervicofacial subcutaneous emphysema and pneumomediastinum after intraoral laser irradiation2009

    • Author(s)
      Imai T, Michizawa M, Arimoto E, Kimoto M, Yura Y
    • Journal Title

      Jouranal of oral and Maxillofacial Surgery 67(2)

      Pages: 428-430

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔癌治療に用いる変異型ヘルペスウイルスの遺伝子解析と生物学的特性2009

    • Author(s)
      高岡洋生、新谷素子、藤田祐生、濱田正和、岩井聡一、由良義明
    • Journal Title

      口腔組織培養学会誌 18(1)

      Pages: 41-42

    • Related Report
      2009 Annual Research Report
  • [Presentation] PKC alpha阻害剤safingolによる細胞死にけるミトコンドリア分裂の関与2011

    • Author(s)
      若林健、濱田正和、竹下彰範、飯井孝年、奥長秀介、岩井聡一、由良義明
    • Organizer
      第48回日本口腔組織培養学会学術大会
    • Place of Presentation
      浦安市
    • Year and Date
      2011-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス扁平上皮癌に対する変異型単純ヘルペスウイルスの抗腫瘍効果2011

    • Author(s)
      飯井孝年
    • Organizer
      第48回日本口腔組織培養学会学術大会
    • Place of Presentation
      千葉県浦安市
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 扁平上皮癌に対する腫瘍融解ウイルス療法の抗腫瘍効果2011

    • Author(s)
      飯井孝年、高橋元、新谷素子、若林健、奥長秀介、竹下彰範、岩井聡一、由良義明
    • Organizer
      第56回日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 飯井孝年2011

    • Author(s)
      飯井孝年
    • Organizer
      第56回日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規融合性単純ヘルペスウイルス1型Rh2の遺伝子構造と腫瘍内増殖様式の検討2011

    • Author(s)
      高橋元
    • Organizer
      第56回日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔扁平上皮癌に対するゲラニルゲラニルトランスフェラーゼ阻害剤とプロテインキナーゼ阻害剤の併用効果の検討2011

    • Author(s)
      濱田正和、岩井聡一、米川敦子、森田祥弘、由良義明
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Induction of syncytia in squamous cell carcinoma tissue by oncolytic herpes simplex virus type 12011

    • Author(s)
      Takahashi G, Okunaga S, Meshii N, Shintani M, Yura Y
    • Organizer
      International Union of Microbiological Societies 2011 Congress International Congress of Virology
    • Place of Presentation
      Sapporo City
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 複製可能型腫瘍融解性ヘルペスウイルス(HSV-1)の作製および腫瘍内増殖様式の検討2011

    • Author(s)
      高橋元、飯井孝年、濱田正和、山本直典、岩井聡一、由良義明
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 活性酸素によるendonuclease Gを介した細胞死の誘導2011

    • Author(s)
      若林健
    • Organizer
      第65回日本口腔科学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス扁平上皮癌に対する腫瘍融解性ウイルスの抗腫瘍効果2011

    • Author(s)
      飯井孝年
    • Organizer
      第65回日本口腔科学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 変異型単純ヘルペスウイル1型RH2の遺伝子解析と腫瘍内増殖様式2010

    • Author(s)
      高橋元、飯井孝年、新谷素子、由良義明
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島市
    • Year and Date
      2010-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Sonoporationが腫瘍融解性ウイルスの感染に及ぼす影響2010

    • Author(s)
      新谷素子, 高橋元, 濱田正和, 山本直典, 青田桂子, 岩井聡一, 由良義明
    • Organizer
      第55回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉市
    • Year and Date
      2010-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of GTPase RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells2010

    • Author(s)
      Hamada M, Miki T, Iwai S, Yura Y
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞融合性ヘルペスウイルスの腫瘍内増殖様式の検討2010

    • Author(s)
      高橋元、新谷素子、濱田正和、山本直典、飯井孝年、由良義明
    • Organizer
      第64回日本口腔科学会学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-06-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 超音波照射が腫瘍融解性ウイルス療法の感染に及ぼす影響2010

    • Author(s)
      新谷素子、三木哲英、濱田正和、青田桂子、岩井聡一、由良義明
    • Organizer
      第64回日本口腔科学会学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-06-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞融合性ヘルペスウイルスの腫瘍内増殖様式の検討2010

    • Author(s)
      高橋元、新谷素子、濱田正和、山本直典、飯井孝年、由良義明
    • Organizer
      第64回日本口腔科学会学術集会
    • Place of Presentation
      札幌プリンスホテル
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 超音波照射が腫瘍融解性ウイルス療法の感染に及ぼす影響2010

    • Author(s)
      新谷素子、三木哲英、濱田正和、青田桂子、岩井聡一、由良義明
    • Organizer
      第64回日本口腔科学会学術集会
    • Place of Presentation
      札幌プリンスホテル
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] ホウ素中性子捕捉療法によるヒト口腔扁平上皮癌におけるmitotoic catastropheの誘導2010

    • Author(s)
      山本直典、藤田祐生、加藤逸郎、岩井聡一、由良義明
    • Organizer
      第34回日本頭頸部癌学会
    • Place of Presentation
      東京 京王プラザホテル
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌に対するゲラニルゲラニルトランスフェラーゼ阻害剤の作用機序2010

    • Author(s)
      三木哲英、濱田正和、山本直典、岩井聡一、由良義明
    • Organizer
      第34回日本頭頸部癌学会
    • Place of Presentation
      東京 京王プラザホテル
    • Year and Date
      2010-06-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] ソノポレーションが腫瘍融解性ウイルスの感染に及ぼす影響2009

    • Author(s)
      新谷素子、赤垣俊輔、三木哲英、濱田正和、青田桂子、岩井聡一、由良義明
    • Organizer
      第46回日本口腔組織培養学会学術大会
    • Place of Presentation
      東京都品川区
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腫瘍融解性ヘルペスウイルスの腫瘍内増殖様式の検討2009

    • Author(s)
      高橋元、新谷素子、由良義明
    • Organizer
      第57回日本ウイルス学会
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 腫瘍融解性ヘルペスウイルスの腫瘍内増殖様式の検討2009

    • Author(s)
      高橋元、新谷素子、由良義明
    • Organizer
      第57回日本ウイルス学会
    • Place of Presentation
      東京都新宿区
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 顔面神経麻痺を併発した下顎骨原発性悪性リンパ腫の1例2009

    • Author(s)
      濱田正和、藤本耕二、太田嘉幸、今井智章、清水英孝、飯井孝年、由良義明
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] GGTase I阻害剤が口腔扁平上皮癌細胞の増殖ならびに遊走能に及ぼす影響2009

    • Author(s)
      三木哲英、濱田正和、赤垣俊輔、新谷素子、野田隆之、青田桂子、岩井聡一、由良義明
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-10-09
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 新規有機無機複合材料の骨再生効果に関する検討2009

    • Author(s)
      須澤佳香、水田法彦、舩木隆文、岩井聡一、由良義明、中野貴由、明石満
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 緑色蛍光タンパク質GFPを用いた口腔がん転移メカニズム解明へのアプローチ2009

    • Author(s)
      森田祥弘、波多賢二、由良義明
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] A novel fusogenic herpes simplex virus mutant for oncolytic virotherapy of oral squamous cell carcinoma2009

    • Author(s)
      Yura Y, Takaoka H, Ogawa F, Shintani M, Iwai S
    • Organizer
      2nd Word Congress of the International Academy of Oral Oncology(IAOO)
    • Place of Presentation
      Tronnto
    • Year and Date
      2009-07-11
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel fusogenic herpes simplex virus mutant for oncolytic virotherapy of oral squamous cell carcinoma2009

    • Author(s)
      Yura Y, Takaoka H, ogawa F, Shintani M, Iwai S
    • Organizer
      2nd Word Congress of the International Academy of oral Oncology (IAOO)
    • Place of Presentation
      Tronto, Canada
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 遅延型アレルギー反応のマウス舌粘膜モデルにおけるデキサメタゾンの効果2009

    • Author(s)
      赤垣俊輔、三木哲英、濱田正和、竹内憲民、岩井聡一、由良義明
    • Organizer
      第19回日本口腔粘膜学会
    • Place of Presentation
      神奈川県葉山町
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規細胞融合性ウイルスの口腔扁平上皮癌細胞と担癌動物における抗腫陽効果の検討2009

    • Author(s)
      新谷素子、高岡洋生、濱田正和、青田桂子、岩井聡一、由良義明
    • Organizer
      第63回日本口腔科学会学術集会
    • Place of Presentation
      浜松市
    • Year and Date
      2009-04-17
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ゲラニルゲラニルトランスフェラーゼ阻害剤GGTI-298と safingol併用による口腔扁平上皮癌細胞のアポトーシス誘導2009

    • Author(s)
      三木哲英、野田隆之、濱田正和、青田桂子、岩井聡一、由良義明
    • Organizer
      第63回日本口腔科学会学術集会
    • Place of Presentation
      浜松市
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] ゲラニルゲラニルトランスフェラーゼ阻害剤GGTI-298とsafingol併用による口腔扁平上皮癌細胞のアポトーシス誘導2009

    • Author(s)
      三木哲英、野田隆之、濱田正和、青田桂子、岩井聡一、由良義明
    • Organizer
      第63回日本口腔科学会学術集会
    • Place of Presentation
      浜松市
    • Year and Date
      2009-04-16
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス舌粘膜における遅延型アレルギー反応モデルの作製2009

    • Author(s)
      赤垣俊輔、三木哲英、濱田正和、竹内憲民、岩井聡一、由良義明
    • Organizer
      第63回日本口腔科学会学術集会
    • Place of Presentation
      浜松市
    • Year and Date
      2009-04-16
    • Related Report
      2009 Annual Research Report
  • [Book] 歯科・口腔外科疾患、特集・口腔内ウイルス感染の診断と治療,ENTONI2011

    • Author(s)
      由良義明、岩井聡一
    • Publisher
      全日本病院出版会
    • Related Report
      2011 Final Research Report
  • [Book] 口腔粘膜疾患、口腔外科学第3版2010

    • Author(s)
      由良義明
    • Publisher
      医歯薬出版
    • Related Report
      2011 Final Research Report
  • [Book] 口腔外科学第3版2010

    • Author(s)
      由良義明(共著)
    • Publisher
      医歯薬出版社
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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