Isolation of molecules synthesized by stromal cells, which regulate tumor invasion and metastasis : application in diagnosis and therapy
| Project/Area Number |
21390538
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Tetsuji 広島大学, 医歯薬学総合研究科, 教授 (00169153)
新谷 智章 広島大学, 病院, 助教 (90403518)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Keywords | 口腔癌 / 浸潤・転移 / 間質細胞 / 細胞増殖 / 細胞遊走 / 蛋白分解活性 / インテグリン / 線維芽細胞 / 細胞接着因子 |
|---|
| Research Abstract |
To assess the participation of stromal components in the progression of oral squamous cell carcinoma(SCC) cells, we investigated the effect of fibroblasts on the proliferation, motility and proteolytic activity of SCC cells. Fibroblasts in the stroma of oral SCC synthesize TSP-1, which induces haptotactic migration and enhances the ability to synthesize matrix metallopeptidase 9(MMP-9) in oral SCC cells. Further type I collagen produced by fibroblasts facilitates the proliferation and migration of oral SCC cells via integrinαvβ8
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] ESR dosimetry study on population of settlements nearby Ust-Kamenogorsk city2009
Author(s)
Zhumadilov K, Ivannikov A, ZharlyganovaD, Zhumadilov Z, Stepanenko V, Apsalikov K, Ali MR, Zhumadilova A, Toyoda S, Endo S, Tanaka K, Okamoto T, Hoshi M
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Journal Title
Kazakhstan. Radiat Environ Biophys
Volume: 48(4)
Pages: 419-425
Related Report
Peer Reviewed
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