Identification of Cancer Stem Cell and its niche system in Oral Cancer
Project/Area Number |
21390539
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Surgical dentistry
|
Research Institution | Hiroshima University |
Principal Investigator |
OKAMOTO Tetsuji 広島大学, 大学院・医歯薬学総合研究科, 教授 (00169153)
|
Co-Investigator(Kenkyū-buntansha) |
TORATANI Shigeaki 広島大学, 病院, 講師 (90172220)
HAYASHIDOU Yasutaka 広島大学, 病院, 講師 (70243251)
SHINTANI Tomoaki 広島大学, 病院, 助教 (90403518)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
|
Keywords | 口腔癌 / 癌幹細胞 / 無血清培地 / CD133 / Sp細胞 / 低酸素 / sphere形成 / 造腫瘍性 / 口腔扁平上皮癌細胞 / side population / hoechst33342 / 無血清培養 / HIF-1遺伝子 / 薬剤耐性遺伝子 / 低酸素培養 / CD133陽性細胞 / sphere形成能 / 低酸素環境 / 抗癌剤 / 細胞増殖因子 |
Research Abstract |
We have revealed that CD133-positive cells in oral squamous cell carcinoma cells has an important role for the sphere formation and side population cells also function for tumorigenicity and drug-resistance activity. In addition, epidermal growth factor, sonic hedgehog, interleukin-6 derived from the OSCC work as niche for the maintenance and property of CD133 cells. These results strongly suggested the possibility that CD133 and/ or Sp cells function as a cancer stem cell in oral squamous cell carcinomas. Thus, targeted therapy against the CD133 and/ or Sp cell might be useful for the OSCC therapy
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Report
(4 results)
Research Products
(48 results)
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[Book] 口腔外科学2010
Author(s)
白砂兼光,古郷幹彦,他
Total Pages
815
Publisher
医歯薬出版
Related Report
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[Book] 口腔外科学2010
Author(s)
白砂兼光, 古郷幹彦, 他
Total Pages
815
Publisher
医歯薬出版
Related Report
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