| Project/Area Number |
21390544
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Kazuma 兵庫医科大学, 医学部, 講師 (50309473)
HASHITANI Susumu 兵庫医科大学, 医学部, 助教 (00330449)
KISHIMOTO Hiromitsu 兵庫医科大学, 医学部, 准教授 (30291818)
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| Research Collaborator |
SEGAWA Emi 兵庫医科大学, 医学部, 助教 (00553778)
ZUSHI Yuusuke 兵庫医科大学, 医学部, 助教 (80581206)
HIROMOTO Takashi 兵庫医科大学, 医学部, 大学院生
YAMAMURA Michiyo 兵庫医科大学, 医学部, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 臨床腫瘍学 / 口腔癌 / 癌幹細胞 / 細胞培養 / 造腫瘍性 / 抗癌剤耐性 / 上皮・間葉移行 / 免疫組織化学 / 浩腫瘍性 |
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| Research Abstract |
The aim of this study is to isolate and identify oral cancer stem cells(CSC) that are considered to be involved in tumor recurrence and metastasis, and to develop the therapy specific for CSC. Various cultured oral squamous carcinoma cells contained SP cells that are included in side population and considered CSC, in 0.04.0.4% of total cell population. The ratio included had a tendency to be increased in cancer cells overexpressing cyclooxygenase-2, cisplatin-resistant cancer cells expressing multidrug resistance gene MDR-1, and cancer cells showing poor differentiation and high invasiveness. There is a possibility to find out a clue for specific therapy by using these CSC-like cells.
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