Effect of mastication on the niche in the hippocampal dentate gyrus
| Project/Area Number |
21390548
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MITOME Masato 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (50261318)
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| Co-Investigator(Kenkyū-buntansha) |
SUDA Naoto 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (90302885)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 咀嚼 / 神経幹細胞 / 海馬 / 歯状回 / 歯学 / 発生・分化 / 脳・神経 |
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| Research Abstract |
Several studies suggested neural stem cells in the hippocampal dentate gyrus are affected by the external circumstances. First, we suggested the reduced mastication influenced the survival of the neural stem cells in the dentate gyrus through the nitric oxide production system. Second, mice were fed hard diet or given blocks of tree for biting for 8 weeks. The survivals of neural stem cells in both of the mastication groups were significantly in creased. In conclusion, these data showed possibilities that the mastication affect the neural plasticity in the central nervous system.
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Report
(4 results)
Research Products
(12 results)
