A fundamental study regarding the cultured periosteum and its scaffold leading to a novel periodontal regenerative treatment
| Project/Area Number |
21390554
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWASE Tomoyuki 新潟大学, 医歯学系, 准教授 (90191999)
KOGAMI Hiroyuki 新潟大学, 医歯学系, 助教 (10463978)
NAGATA Masaki 新潟大学, 医歯学総合病院, 講師 (10242439)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Keywords | 歯周組織 / 再生医学 / 細胞治療 / 再生骨膜 / 細胞培養 / 生体材料 / 基材 / 硬組織評価 / 培養骨膜シート / 多孔性ポリ乳酸膜 / 接着分子 / 冷凍保存 / アルカリホスファターゼ / カテキン / 抗酸化作用 / 近赤外線イメージング / 骨膜細胞 / ハイドロキシアパタイト / 石灰化 / ポリ乳酸カプロラクトン重合体 / cambium layer / 幹細胞 |
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| Research Abstract |
A novel periodontal regenerative treatment using autologous cultured periosteal sheet with an osteogenic property attracts attention nowadays.
We examined the cell-biological characteristics of this sheet and the reaction of various scaffolding materials to this biological sheet through in vitro and in vivo experiments. It was suggested that cultured periosteal sheet has stem cell-like cells, and has a possibility to express osteogenic property by induction of cell differentiation. Cell adhesion was improved by making processing some treatment on the surface of high molecular or inorganic scaffolding materials, and was able to support a cell migration and calcification.
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Report
(4 results)
Research Products
(95 results)
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[Journal Article] Collagen-coated poly(L-lactide-co-ε-caprolactone) film : A promising scaffold for cultured periosteal sheets2010
Author(s)
Kawase T, Yamanaka K, Suda Y, Kaneko T, Okuda K, Kogami H, Nakayama H, Nagata M, (他2名、1, 5, 6, 8番目)
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Journal Title
Periodontol
Volume: 81(11)
Pages: 1653-1662
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Peer Reviewed
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[Journal Article]2009
Author(s)
奥田一博
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Journal Title
日常臨床における再生療法のテクニックと長期経過(株式会社ヒョーロン・パブリッシャーズ)
Pages: 164-169
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[Journal Article]2009
Author(s)
奥田一博
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Journal Title
遺伝子医学MOOK13患者までとどいている再生誘導治療-バイオマテリアル、生体シグナル因子、細胞を利用した患者のための再生医療の実際-(株式会社メディカルドゥ)
Pages: 225-229
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[Presentation] An osteogenic grafting complex composed of human periosteal sheet and its scaffolding material, a porous poly(L-lactic acid) membrane : biocompatibility, biodegradation, and cell fate in vivo2011
Author(s)
Kawase T, Tanaka T, Nishimoto T, Okuda K, Nagata M(他2名、1, 4, 5番目)
Organizer
Tissue Engineering & Regenerative Medicine International Society 2011 Asia Pacific Meeting
Place of Presentation
Grand Copthome Warwefront Hotel, Singapore
Year and Date
2011-08-04
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[Presentation] Non-invasive evaluation of the osteogenic activity of alveolar bone-derived human periosteal sheets in animal implantation models by in vivo near-infrared(NIR) optical imaging2010
Author(s)
Kawase T, Nakayama H, Okuda K, Kogami H, Nagata M,(他2名、1, 3, 4, 5番目)
Organizer
The 96th Annual Meeting of the American Academy of Periodontology
Place of Presentation
Honolulu, HI, USA
Year and Date
2010-11-01
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[Presentation] The human cultured periosteal sheet for periodontal regeneration : a salmon collagen. coated mesh, a functionally potent scaffold, to upregulate the osteogenic potential2009
Author(s)
Okuda K, Kawase T, Kogami H, Nakayama H, Nagata M(他1名、1, 2, 3, 5番目)
Organizer
The 95th Annual Meeting of the American Academy of Periodontology
Place of Presentation
Boston, MA, USA
Year and Date
2009-09-01
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