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Basic study to unify periodontal medicine and anti-aging medicine

Research Project

Project/Area Number 21390556
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionHiroshima University
Kyushu University

Principal Investigator

NISHIMURA Fusanori  九州大学, 歯学研究院, 教授 (80208222)

Co-Investigator(Kenkyū-buntansha) ASANO Tomoichiro  広島大学, 大学院医歯薬保健学研究院, 教授 (70242063)
ABIKO Yoshimitsu  日本大学, 松戸歯学部, 教授 (70050086)
Project Period (FY) 2009-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords歯周病 / 軽微な慢性炎症 / 脂肪組織 / 炎症細胞 / 耐糖能異常 / 虚血性心疾患リスク / マクロファージ / インスリン抵抗性 / 2型糖尿病 / 高感度CRP / 脂肪細胞-マクロファージ相互作用 / 肥満 / 喫煙 / レプチン / 動脈硬化 / マイクロRNA / sICAM-1 / 歯周医学 / 門脈系 / 微細慢性炎症 / サイトカイン / 敗血症 / 脂肪細胞-マクロファージ相互作用
Research Abstract

Periodontal disease is not merely a local infectious disease, but also a low-grade inflammatory disease for the host which may greatly influences glucose tolerance as well as cardiovascular risk. Therefore, our understanding the mechanisms behind this phenomenon at molecular basis is important to establish healthy longevity. Here, we found activated immune cells by periodontal infection migrated into adipose tissues, interacted with adipocytes, thereby enhancing immune responses as well as influencing lipid and glucose metabolism. It is strongly indicataed that the purpose of periodontal treatment is not only to avoid tooth extraction, but also to achieve healthy longevity.

Report

(5 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (46 results)

All 2013 2012 2011 2010

All Journal Article (24 results) (of which Peer Reviewed: 19 results) Presentation (15 results) (of which Invited: 1 results) Book (7 results)

  • [Journal Article] Improvement of glycated hemoglobin in Japanese subjects with type 2 diabetes by resolution of periodontal inflammation using adjunct topical antibiotics : results from the Hiroshima Study2013

    • Author(s)
      Munenaga Y, The Hiroshima Study Group, Yamashina T, Tanaka J, Nishimura F
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 100 Issue: 1 Pages: 53-60

    • DOI

      10.1016/j.diabres.2013.01.028

    • Related Report
      2013 Final Research Report
  • [Journal Article] Circulating TNF receptor 2 is associated with the development of chronic kidney disease in non-obese Japanese patients with type 2 diabetes.2013

    • Author(s)
      Izumi Y
    • Journal Title

      Diabetes Res Clin Pract.

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of glycated hemoglobin in Japanese subjects with type 2 diabetes by resolution of periodontal inflammation using adjunct topical antibiotics: results from the Hiroshima Study.2013

    • Author(s)
      Munenaga Y
    • Journal Title

      Diabetes Res Clin Pract.

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model2012

    • Author(s)
      Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 53 Pages: 44526-44535

    • DOI

      10.1074/jbc.m112.397133

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages2012

    • Author(s)
      Kumamoto S, Kushiyama A, Nakatsu Y, Sakoda H, Fujishiro M, Iwashita M, Ohno H, Zhang J, Guo Y, Aburatani H, Kamata H, Nishimura F, Asano T.
    • Journal Title

      Obesity Research and Clinical Practice

      Volume: 6 Issue: 4 Pages: 288-297

    • DOI

      10.1016/j.orcp.2012.05.005

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smoking and adipose tissue inflammation suppress leptin expression in Japanese obese males : Potential mechanism of resistance to weight loss among Japanese obese smokers2012

    • Author(s)
      Nagayasu S, Suzuki S, Yamashita A, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Nagasaka S, Yabe D, Nishimura F
    • Journal Title

      Tob Induc Dis

      Volume: 10 Issue: 1 Pages: 3-3

    • DOI

      10.1186/1617-9625-10-3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development2012

    • Author(s)
      Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Issue: 2 Pages: 291-298

    • DOI

      10.1161/atvbaha.111.234559

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.2012

    • Author(s)
      Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
    • Journal Title

      American Journal of Physiology - Endocrinology and Metabolism

      Volume: 302 Issue: 3 Pages: 286-296

    • DOI

      10.1152/ajpendo.00324.2011

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Valsartan, independently of AT1 receptor or PPAR_γ, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes2012

    • Author(s)
      Iwashita M, et al
    • Journal Title

      Am J Physiol-Endocrinol Metab

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine oxidoreductase is involved in macrophage foam cell formati on and atherosclerosis development2012

    • Author(s)
      Kushiyama A, et al
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smoking and adipose tissue inflammation suppress leptin expression in Japanese obese males : Potential mechanism of resistance to weight loss among Japanese obese smokers2012

    • Author(s)
      Nagayasu S, et al
    • Journal Title

      Tob Induc Dis

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smoking, white blood cell counts, and TNF system activity in Japanese male subjects with normal glucose tolerance2011

    • Author(s)
      Watanabe N
    • Journal Title

      Tobacco Induced Diseases

      Volume: 9 Issue: 1 Pages: 12-12

    • DOI

      10.1186/1617-9625-9-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011

    • Author(s)
      Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 23 Pages: 20812-20822

    • DOI

      10.1074/jbc.m110.206904

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011

    • Author(s)
      Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
    • Journal Title

      Am J Physiol-Cell Physiol

      Volume: 300

    • Related Report
      2013 Final Research Report
  • [Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation : Potential link with metabolic complications2011

    • Author(s)
      Nakarai, H, Yamashita, A, Nagayasu, S, Iwashita, M, Kumamoto, S, Ohyama, H, Hata, M, Soga, Y, Kushiyama, A, Asano, T, Abiko, Y, Nishimura, F
    • Journal Title

      Innate Immunity

      Volume: 18 Issue: 1 Pages: 164-170

    • DOI

      10.1177/1753425910393370

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal disease and hyper-triglyceridemia in Japanese subjects : potential association with enhanced lipolysis2011

    • Author(s)
      Nakarai H, Yamashita A, Takagi M, Adachi M, Sugiyama M, Noda H, Katano M, Yamakawa R, Nakayama K, Takumiya H, Nakai Y, Taniguchi A, Nishimura F
    • Journal Title

      Metabolism

      Volume: 60 Issue: 6 Pages: 823-829

    • DOI

      10.1016/j.metabol.2010.07.034

    • Related Report
      2013 Final Research Report
  • [Journal Article] Periodontal disease and hypertriglyceridemia in Japanese subjects : potential association with enhanced lipolysis.2011

    • Author(s)
      Nakarai H, et al.
    • Journal Title

      Metabolism

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced inflammation : potential link with metabolic complications.2011

    • Author(s)
      Nakarai H, et al.
    • Journal Title

      Innate Immunity

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity2010

    • Author(s)
      Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T.
    • Journal Title

      J. Biol. Chem

      Volume: 285 Issue: 43 Pages: 33018-33027

    • DOI

      10.1074/jbc.m110.137836

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase2010

    • Author(s)
      Yoneda M, Guo Y, Ono H, Nakatsu Y, Zhang J, Cui XL, Iwashita M, Kumamoto S, Tsuchiya Y, Sakoda H, Fujishiro M, Kushiyama A, Koketsu Y, Kikuchi T, Kamata H, Nishimura F, Asano T
    • Journal Title

      Obese Res Clin Pract

      Volume: 4 Issue: 3 Pages: e201-e207

    • DOI

      10.1016/j.orcp.2010.02.002

    • Related Report
      2013 Final Research Report
  • [Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy2010

    • Author(s)
      Cui X, Kushiyama A, Yoneda M, Nakatsu Y, Guo Y, Zhang J, Ono H, Kanna M, Sakoda H, Ono H, Kikuchi T, Fujishiro M, Shiomi M, Kamata H, Kurihara H, Kikuchi M, Kawazu S, Nishimura F, Asano T.
    • Journal Title

      Diabetes Res. Clin. Pract

      Volume: 87 Issue: 1 Pages: 57-63

    • DOI

      10.1016/j.diabres.2009.10.011

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal conditions in Werner syndrome2010

    • Author(s)
      Nishimura F, Arakawa M, Goto M
    • Journal Title

      J Periodontol

      Volume: 81 Issue: 1 Pages: 3-3

    • DOI

      10.1902/jop.2009.090461

    • Related Report
      2013 Final Research Report
  • [Journal Article] Periodontal conditions in Werner syndrome2010

    • Author(s)
      Nishimura F, et al.
    • Journal Title

      Journal of periodontology 81

      Pages: 3-3

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy2010

    • Author(s)
      Cui, et al.
    • Journal Title

      Diabetes Res Clin Pract 87

      Pages: 57-63

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歯周病と糖尿病の関連性からひもとくOral-Systemic Medicineの分子基盤(日本学術会議シンポジウム高齢社会におけるOral-systemic medicine)2013

    • Author(s)
      西村英紀
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山
    • Year and Date
      2013-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯周病と糖尿病の関連性からひもとくOral-Systemic Medicineの分子基盤(ワークショップ11口腔内炎症性疾患と全身の連関:Oral-Systemic Medicineの新たな展開)2013

    • Author(s)
      西村英紀
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2013-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] The periodontal host response with type 2 diabetes2013

    • Author(s)
      Nishimura F
    • Organizer
      第8回グローバルCOE国際シンポジウムMolecular Science in Oral-Systemic Medicine-Winter Seminar-
    • Place of Presentation
      東京医科歯科大学,Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] The periodontal host response with type 2 diabetes.2013

    • Author(s)
      Nishimura F
    • Organizer
      東京医科歯科大学第8回グローバルCOE国際シンポジウム Molecular Science in Oral-Systemic Medicine-Winter Seminar-.
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Key note lecture - Periodontal Disease : More than sixth complication of diabetes mellitus2012

    • Author(s)
      Nishimura F
    • Organizer
      9^<th> IDF-WPR Congress 4^<th> AASD Scientific Meeting(in Symposium"Diabetes and Periodontal Disease")
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-11-25
    • Related Report
      2013 Final Research Report
  • [Presentation] New therapeutic concept against severe periodontitis in type 2 diabetic subjects. Lunch &Learning 322012

    • Author(s)
      Nishimura F
    • Organizer
      90^<th> General Session of International Association for Dental Research
    • Place of Presentation
      Iguacu Falls, Brazil
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病患者に対する歯周病治療ガイドライン; UP-DATE2012

    • Author(s)
      西村英紀
    • Organizer
      第22回日本歯科医学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖尿病患者に対する歯周治療は何を標的とするか2012

    • Author(s)
      西村英紀
    • Organizer
      2012年(第137)回日本歯科保存学会秋季学術大会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Key note lecture - Periodontal Disease: More than sixth complication of diabetes mellitus.2012

    • Author(s)
      Nishimura F
    • Organizer
      9th IDF-WPR Congress 4th AASD Scientific Meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Annual Research Report
  • [Presentation] 基調講演:糖尿病に対する統合医療の一環としての歯周病管理2012

    • Author(s)
      西村英紀
    • Organizer
      第16回日本統合医療学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] New therapeutic concept against severe periodontitis in type 2 diabetic subjects.2012

    • Author(s)
      Nishimura F
    • Organizer
      90th General Session of International Association for Dental Research
    • Place of Presentation
      Iguacu Falls, Brazil
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖尿病のリスク因子としての歯周病2011

    • Author(s)
      西村英紀
    • Organizer
      第45回糖尿病学の進歩
    • Place of Presentation
      福岡市(招待講演)
    • Year and Date
      2011-02-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] The periodontal host response with type 2 diabetes2011

    • Author(s)
      Nishimura F
    • Organizer
      24^<th> Indonesian Dentist Association Congress
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2013 Final Research Report
  • [Presentation] The periodontal host response with type 2 diabetes2011

    • Author(s)
      Nishimura F
    • Organizer
      24^<th> Indonesian Dentist Association Congress
    • Place of Presentation
      Bali, Indonesia(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Periodontal Host Response with Pre-metabolic Syndrome2010

    • Author(s)
      Nishimura F
    • Organizer
      Kaohsiung Medical University 2010 Research Day Symposium
    • Place of Presentation
      Kaohsiung, Taiwan
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Book] 「代謝・内分泌疾患診療 最新ガイドライン」糖尿病と歯周病2012

    • Author(s)
      西村英紀, 門脇孝、下村伊一郎編(共著)
    • Publisher
      総合医学社
    • Related Report
      2013 Final Research Report
  • [Book] 代謝・内分泌疾患診療 最新ガイドライン2012

    • Author(s)
      西村英紀
    • Total Pages
      300
    • Publisher
      総合医学社
    • Related Report
      2012 Annual Research Report
  • [Book] 隣接医学シリーズ 糖尿病と歯科治療2012

    • Author(s)
      山下明子
    • Total Pages
      250
    • Publisher
      デンタルダイアモンド社
    • Related Report
      2012 Annual Research Report
  • [Book] 「糖尿病の療養指導2011」糖尿病の危険因子としての歯周病2011

    • Author(s)
      西村英紀, 日本糖尿病学会編(共著)
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] VI.糖尿病の治療-4-心血管リスク管理における糖尿病合併症治療-13歯周病, 門脇孝総編集, 植木浩二郎, 小田原雅人, 佐倉宏, 浜野久美子, 松田昌文, 森保道編集「心血管リスクを防ぐ糖尿病診療ガイド」(共著)2011

    • Author(s)
      西村英紀
    • Publisher
      南山堂
    • Related Report
      2013 Final Research Report
  • [Book] 心血管リスクを防ぐ糖尿病診療ガイド2011

    • Author(s)
      西村英紀
    • Total Pages
      420
    • Publisher
      南山堂
    • Related Report
      2010 Annual Research Report
  • [Book] 「科学的根拠に基づく糖尿病診療ガイドライン2010」11.糖尿病と歯周病2010

    • Author(s)
      河野隆幸, 西村英紀, 日本糖尿病学会編集
    • Publisher
      南光堂
    • Related Report
      2013 Final Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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