Basic study to unify periodontal medicine and anti-aging medicine
Project/Area Number |
21390556
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Periodontal dentistry
|
Research Institution | Hiroshima University Kyushu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
ASANO Tomoichiro 広島大学, 大学院医歯薬保健学研究院, 教授 (70242063)
ABIKO Yoshimitsu 日本大学, 松戸歯学部, 教授 (70050086)
|
Project Period (FY) |
2009-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
Keywords | 歯周病 / 軽微な慢性炎症 / 脂肪組織 / 炎症細胞 / 耐糖能異常 / 虚血性心疾患リスク / マクロファージ / インスリン抵抗性 / 2型糖尿病 / 高感度CRP / 脂肪細胞-マクロファージ相互作用 / 肥満 / 喫煙 / レプチン / 動脈硬化 / マイクロRNA / sICAM-1 / 歯周医学 / 門脈系 / 微細慢性炎症 / サイトカイン / 敗血症 / 脂肪細胞-マクロファージ相互作用 |
Research Abstract |
Periodontal disease is not merely a local infectious disease, but also a low-grade inflammatory disease for the host which may greatly influences glucose tolerance as well as cardiovascular risk. Therefore, our understanding the mechanisms behind this phenomenon at molecular basis is important to establish healthy longevity. Here, we found activated immune cells by periodontal infection migrated into adipose tissues, interacted with adipocytes, thereby enhancing immune responses as well as influencing lipid and glucose metabolism. It is strongly indicataed that the purpose of periodontal treatment is not only to avoid tooth extraction, but also to achieve healthy longevity.
|
Report
(5 results)
Research Products
(46 results)
-
-
-
-
[Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model2012
Author(s)
Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
-
Journal Title
J Biol Chem
Volume: 287
Issue: 53
Pages: 44526-44535
DOI
Related Report
Peer Reviewed
-
[Journal Article] Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages2012
Author(s)
Kumamoto S, Kushiyama A, Nakatsu Y, Sakoda H, Fujishiro M, Iwashita M, Ohno H, Zhang J, Guo Y, Aburatani H, Kamata H, Nishimura F, Asano T.
-
Journal Title
Obesity Research and Clinical Practice
Volume: 6
Issue: 4
Pages: 288-297
DOI
Related Report
Peer Reviewed
-
[Journal Article] Smoking and adipose tissue inflammation suppress leptin expression in Japanese obese males : Potential mechanism of resistance to weight loss among Japanese obese smokers2012
Author(s)
Nagayasu S, Suzuki S, Yamashita A, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Nagasaka S, Yabe D, Nishimura F
-
Journal Title
Tob Induc Dis
Volume: 10
Issue: 1
Pages: 3-3
DOI
Related Report
Peer Reviewed
-
[Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development2012
Author(s)
Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
-
Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32
Issue: 2
Pages: 291-298
DOI
Related Report
Peer Reviewed
-
[Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.2012
Author(s)
Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
-
Journal Title
American Journal of Physiology - Endocrinology and Metabolism
Volume: 302
Issue: 3
Pages: 286-296
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011
Author(s)
Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
-
Journal Title
J Biol Chem
Volume: 286
Issue: 23
Pages: 20812-20822
DOI
Related Report
Peer Reviewed
-
[Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011
Author(s)
Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
-
Journal Title
Am J Physiol-Cell Physiol
Volume: 300
Related Report
-
[Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation : Potential link with metabolic complications2011
Author(s)
Nakarai, H, Yamashita, A, Nagayasu, S, Iwashita, M, Kumamoto, S, Ohyama, H, Hata, M, Soga, Y, Kushiyama, A, Asano, T, Abiko, Y, Nishimura, F
-
Journal Title
Innate Immunity
Volume: 18
Issue: 1
Pages: 164-170
DOI
Related Report
Peer Reviewed
-
[Journal Article] Periodontal disease and hyper-triglyceridemia in Japanese subjects : potential association with enhanced lipolysis2011
Author(s)
Nakarai H, Yamashita A, Takagi M, Adachi M, Sugiyama M, Noda H, Katano M, Yamakawa R, Nakayama K, Takumiya H, Nakai Y, Taniguchi A, Nishimura F
-
Journal Title
Metabolism
Volume: 60
Issue: 6
Pages: 823-829
DOI
Related Report
-
-
-
[Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity2010
Author(s)
Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T.
-
Journal Title
J. Biol. Chem
Volume: 285
Issue: 43
Pages: 33018-33027
DOI
Related Report
Peer Reviewed
-
[Journal Article] Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase2010
Author(s)
Yoneda M, Guo Y, Ono H, Nakatsu Y, Zhang J, Cui XL, Iwashita M, Kumamoto S, Tsuchiya Y, Sakoda H, Fujishiro M, Kushiyama A, Koketsu Y, Kikuchi T, Kamata H, Nishimura F, Asano T
-
Journal Title
Obese Res Clin Pract
Volume: 4
Issue: 3
Pages: e201-e207
DOI
Related Report
-
[Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy2010
Author(s)
Cui X, Kushiyama A, Yoneda M, Nakatsu Y, Guo Y, Zhang J, Ono H, Kanna M, Sakoda H, Ono H, Kikuchi T, Fujishiro M, Shiomi M, Kamata H, Kurihara H, Kikuchi M, Kawazu S, Nishimura F, Asano T.
-
Journal Title
Diabetes Res. Clin. Pract
Volume: 87
Issue: 1
Pages: 57-63
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-