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The basic study for the progression of the order-made medicine by cytokines for periodontal tissue regeneration

Research Project

Project/Area Number 21390557
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionHiroshima University

Principal Investigator

KURIHARA Hidemi  広島大学, 医歯薬学総合研究科, 教授 (40161765)

Co-Investigator(Kenkyū-buntansha) SHIBA Hideki  広島大学, 病院, 講師 (60260668)
MIZUNO Noriyoshi  広島大学, 医歯薬学総合研究科, 助教 (60325181)
TAKEDA Katsuhiro  広島大学, 医歯薬学総合研究科, 助教 (10452591)
HINO Takamune  広島大学, 病院, 講師 (20274102)
IWATA Tomoyuki  広島大学, 病院, 助教 (30418793)
HAYASHIDA Kouichi  広島大学, 病院, 助教 (10437585)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywordsサイトカイン療法 / オーダーメード / 歯周組織再生 / 宿主応答
Research Abstract

In vivo study, two weeks after the BDNF application, periodontal tissue regeneration was insufficient, but invasion of epithelial cells to defects was not observed. TrkB, PCNA and OPN-positive cells were detected on the denuded root surface, around the regenerating alveolar bone and in the soft connective tissue of regenerating periodontal tissues. TrkB positive cells may quickly responded to applied BDNF and started to proliferate and differentiate for the periodontal tissue regeneration within 2 weeks. Furthermore, we investigated the trkB single nucleotide polymorphisms(SNPs) which are reported to have some relationships with Alzheimer' s disease. We also compared effect of BDNF on HAS-1 mRNA expression on human gingival fibroblasts with the results of SNP analyses

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (12 results)

  • [Journal Article] Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrinα(V)β(3)-FAK cascade2011

    • Author(s)
      Matsuda S, Fujita T, Kajiya M, Takeda K, Shiba H, KawaguchiH, Kurihara H
    • Journal Title

      J Cell Physiol

      Volume: 227(5) Pages: 2123-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of High-Molecular-Weight Hyaluronic Acidas a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration2011

    • Author(s)
      Takeda K, Sakai N, ShibaH, Nagahara T, Fujita T, Kajiya M, IwataT, Matsuda S, Kawahara K, Kawaguchi H, Kurihara H
    • Journal Title

      Tissue Eng Part A

      Volume: 17(7-8) Pages: 955-67

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteome analysis of proteins related to aggressive periodontitis combined withneutrophil chemo taxis dysfunction2011

    • Author(s)
      Mizuno N, Niitani M, Shiba H, Iwata T, Hayashi I, Kawaguchi H, Kurihara H.
    • Journal Title

      J Clin Periodontol

      Volume: 38 Issue: 4 Pages: 310-7

    • DOI

      10.1111/j.1600-051x.2010.01693.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration.2011

    • Author(s)
      Katsuhiro Takeda, et al.
    • Journal Title

      Tissue Engineering Part A.

      Volume: April17(7-8) Pages: 955-967

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The antimicrobial peptide LL37 induces the migration of human pulp cells : a possible adjunct for regenerative endodontics2010

    • Author(s)
      Kajiya M, Shiba H, Komatsuzawa H, Ouhara K, Fujita T, Takeda K, Uchida Y, Mizuno N, KawaguchiH, Kurihara H
    • Journal Title

      J Endod

      Volume: 36(6) Pages: 1009-13

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expressions of claudin-1 and E-cadherin in junctional epithelium2010

    • Author(s)
      Fujita T, Hayashida K, Shiba H, Kishimoto A, Matsuda S, Takeda K, Kawaguchi H, Kurihara H
    • Journal Title

      Periodontal Res

      Volume: 45(4) Pages: 579-82

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 脳由来神経栄養因子(BDNF)の血管内皮細胞透過性に及ぼす影響についての研究2011

    • Author(s)
      松田真司、栗原英見
    • Organizer
      第135回日本歯科保存学会秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immunohistochemical study of periodontal tissue regenerative process by BDNF2011

    • Author(s)
      Akihiro Konishi, Hidemi Kurihara
    • Organizer
      4th Hiroshima Conference on Education Science in Dentistry
    • Place of Presentation
      広島
    • Year and Date
      2011-10-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] BDNFによる歯周組織再生カスケードの免疫組織化学的検討2011

    • Author(s)
      小西昭弘、栗原英見
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Brain-Derived Neurotrophic Factor(BDNF) Induces Migration of Endothelial Cells : Shinji Matsuda2011

    • Author(s)
      Hidemi Kurihara
    • Organizer
      89th General session and Exhibition of the international association for dental research
    • Place of Presentation
      サンディエゴ、USA
    • Year and Date
      2011-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Brain-Derived Neurotrophic Factor (BDNF) Induces Migration of Endothelial Cells2011

    • Author(s)
      Shinji Matsuda, Hidemi Kurihara
    • Organizer
      89th General session and Exhibition of the international association for dental research
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-03-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発2011

    • Author(s)
      武田克浩、柴秀樹、藤田剛、松田真司、小西昭弘、片桐菜穂子、河口浩之、栗原英見
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Brain-derived Neurotrophic Factor/ Hyaluronic Acid Complex Enhances Periodontal Tissue Regeneration2010

    • Author(s)
      K. Takeda, H. Shiba, H. Kawaguchi, H. Kurihara
    • Organizer
      The Korean Academy of Periodontology. The 50^<th> Anniversary and International Congress of Scientific Meeting
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2010-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Brain-derived Neurotrophic Factor/Hyaluronic Acid Complex Enhances Periodontal Tissue Regeneration2010

    • Author(s)
      Katsuhiro Takeda, Hidemi Kurihara
    • Organizer
      50^<th> Korean Academy of Periodontology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳由来神経栄養因子(BDNF)はヒト歯肉線維芽細胞のTrkBを介してヒアルロン酸合成酵素発現を促進する2010

    • Author(s)
      片桐菜穂子, 武田克浩, 柴秀樹, 小西昭弘, 橘高瑞穂, 藤田剛, 松田真司, 河口浩之, 栗原英見
    • Organizer
      第53回秋季日本歯周病学会学術大会
    • Place of Presentation
      香川
    • Year and Date
      2010-09-19
    • Related Report
      2011 Final Research Report
  • [Presentation] BDNFは血管内皮細胞遊走過程におけるintegrinの発現、およびFocal Adhesion Kinase(FAK)のリン酸化を制御する2010

    • Author(s)
      松田真司, 栗原英見
    • Organizer
      第53回日本歯周病学会春季学術大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳由来神経栄養因子(BDNF)は血管内皮細胞遊走過程におけるintegrinの発現、及びFocal adhesion kinase(FAK)のリン酸化を制御する2010

    • Author(s)
      松田真司, 藤田剛, 加治屋幹人, 武田克浩, 柴秀樹, 河口浩之, 栗原英見
    • Organizer
      第53回日本歯周病学会学術大会(春季)
    • Place of Presentation
      岩手
    • Year and Date
      2010-05-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発-根面処理併用効果の検討-2010

    • Author(s)
      小西昭弘、武田克浩、柴秀樹、林田浩一、橘高瑞穂、藤田剛、松田真司、河口浩之、橋本正道、辻紘一郎、栗原英見
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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