| Project/Area Number |
21390557
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KURIHARA Hidemi 広島大学, 医歯薬学総合研究科, 教授 (40161765)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBA Hideki 広島大学, 病院, 講師 (60260668)
MIZUNO Noriyoshi 広島大学, 医歯薬学総合研究科, 助教 (60325181)
TAKEDA Katsuhiro 広島大学, 医歯薬学総合研究科, 助教 (10452591)
HINO Takamune 広島大学, 病院, 講師 (20274102)
IWATA Tomoyuki 広島大学, 病院, 助教 (30418793)
HAYASHIDA Kouichi 広島大学, 病院, 助教 (10437585)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | サイトカイン療法 / オーダーメード / 歯周組織再生 / 宿主応答 |
|---|
| Research Abstract |
In vivo study, two weeks after the BDNF application, periodontal tissue regeneration was insufficient, but invasion of epithelial cells to defects was not observed. TrkB, PCNA and OPN-positive cells were detected on the denuded root surface, around the regenerating alveolar bone and in the soft connective tissue of regenerating periodontal tissues. TrkB positive cells may quickly responded to applied BDNF and started to proliferate and differentiate for the periodontal tissue regeneration within 2 weeks. Furthermore, we investigated the trkB single nucleotide polymorphisms(SNPs) which are reported to have some relationships with Alzheimer' s disease. We also compared effect of BDNF on HAS-1 mRNA expression on human gingival fibroblasts with the results of SNP analyses
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