Elucidation of the influence that degradation of renal function with aging gives to bone metabolism and periodontal disease

• Project/Area Number: 21390558
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Niigata University
• Principal Investigator: YOSHIHARA Akihiro 新潟大学, 医歯学系, 教授 (50201033)
• Co-Investigator(Kenkyū-buntansha): MIYAZAKI Hideo 新潟大学, 医歯学系, 教授 (00157629) ; ITO Kayoko 新潟大学, 医歯学総合病院, 助教 (80401735)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: 含公衆衛生学 / 栄養学 / 歯の喪失 / 腎機能低下 / 高齢者 / 経年調査 / 歯周病 / 骨代謝 / 慢性腎機能低下

Research Abstract

This study examined whether low renal function is associated with the bone metabolism and contributing to periodontal disease among community-dwelling elderly Japanese. We selected 674 subjects aged from 55 to 74 years old. Serum cystatin C level was used to assess renal dysfunction. There were significant relationship between serum systatin C level at baseline and the number of remaining teeth or between serum systatin C longitudinal change and the number of missing teeth. In addition, multiple regression analysis showed that the percentage of sites with> 4mm or> 6mm clinical attachment levels was significantly associated with serum osteocalcin levels. Low renal function and reduction of renal function were associated with periodontal disease including tooth loss.

Research Products

• [Journal Article] Periodontal Disease and Decreased KidneyFunction in Japanese Elderly (2012)
  • Author(s): M. Iwasaki, G. W. Taylor, W. Nesse, A. issink, A. Yoshihara, H. Miyazaki
  • Journal Title: American Journal of Kidney Disease Volume: 59(2) Pages: 202-209
  • Peer Reviewed
• [Journal Article] The association between renal function and tooth loss in Japanese community-dwelling postmenopausal women (2011)
  • Author(s): A.Yoshihara, et al
  • Journal Title: Gerodontology Volume: (未定)(印刷中) Issue: 2
  • DOI: 10.1111/j.1741-2358.2011.00481.x
  • Year and Date: 2011-05-10
  • Peer Reviewed
• [Journal Article] Relationship between bone fragility of themandibular inferior cortex and tooth lossrelated to periodontal disease in older people (2011)
  • Author(s): A. Yoshihara, T. Deguchi, H. Miyazaki
  • Journal Title: Community Dental Health Volume: 28(2) Pages: 165-9
  • Peer Reviewed
• [Journal Article] Glomerular filtration rate and10-year mortality in a 70-year-oldcommunity-dwelling Japanese population (2011)
  • Author(s): Y. Takata, T. Ansai, A. Yoshihara, H. Miyazaki
  • Journal Title: Aging Clinical and Experimental Research Volume: 23 Pages: 223-230
  • Peer Reviewed
• [Journal Article] Relationship among bone turnover, renalfunction and periodontal disease in elderlyJapanese (2011)
  • Author(s): A. Yoshihara, Y. Hayashi, H. Miyazaki
  • Journal Title: Journal of Periodontal Research Volume: 46(4) Pages: 491-496
  • Peer Reviewed
• [Journal Article] Relationship betweenperiodontal disease and bone metabolism inthe elderly (2011)
  • Author(s): A. Yoshihara
  • Journal Title: Journal of Dental Health Volume: 61 Pages: 178-182
  • Peer Reviewed
• [Journal Article] IV透析と歯周病(1)腎機能と歯周罹患との関連 (2011)
  • Author(s): 葭原明弘、宮崎秀夫
  • Journal Title: 臨床透析 Volume: Vol.27, no.6 Pages: 673-678
• [Journal Article] Relationship among bone turnover, renal function and periodontal disease in elderly Japanese (2011)
  • Author(s): A.Yoshihara, et al
  • Journal Title: Journal of Periodontal Research Volume: 46 Issue: 4 Pages: 491-496
  • DOI: 10.1111/j.1600-0765.2011.01365.x
  • Peer Reviewed
• [Journal Article] The association between renal function and tooth loss in Japanese community-dwelling postmenopausal women
  • Author(s): A. Yoshihara, K. Nakamura, H. Miyazaki
  • Journal Title: Gerodontology Volume: (in press)
  • Peer Reviewed
• [Presentation] Low renal function and the remaining teeth in postmenopausal women (2011)
  • Author(s): A.Yoshihara
  • Organizer: International Symposium on Oral Health Education and Research
  • Place of Presentation: Blue Sky Hotel, Balikpapan, Indonesia
  • Year and Date: 2011-12-11
• [Presentation] Association between renal function and tooth loss incommunity-dwelling women (2011)
  • Author(s): 葭原明弘
  • Organizer: 第89回国際歯科研究学会
  • Place of Presentation: サンディエゴコンベンションセンター
  • Year and Date: 2011-03-17
• [Presentation] Low renal function and theremaining teeth in postmenopausal women (2011)
  • Author(s): A. Yoshihara
  • Organizer: International Symposium on Oral Health Education and Research
  • Place of Presentation: Indnesia
• [Presentation] Association between renal function and toothloss in community-dwelling women (2011)
  • Author(s): A. Yoshihara, K. Nakamura, H. Miyazaki
  • Organizer: 89th General Session of the IADR
  • Place of Presentation: USA
• [Presentation] Relationship between oral disease and bone metabolism in elderly (2010)
  • Author(s): A. Yoshihara
  • Organizer: International Symposium for Global Oral health Science Niigata 2010
  • Place of Presentation: Niigata University Yujin Memorial Hall
  • Year and Date: 2010-10-09
• [Presentation] Relation of bone turnover markers to periodontal disease in elderly (2010)
  • Author(s): A. Yoshihara, Y. Hayashi, H. Miyazaki
  • Organizer: 88th GeneralSession of the IADR
  • Place of Presentation: バルセロナ
• [Presentation] Peridontal disease may affect kidneyfunction in a community-based Japanese older population (2010)
  • Author(s): M. Iwasaki, A. Yoshihara, H. Miyazaki
  • Organizer: 日本口腔衛生学会
  • Place of Presentation: 新潟
• [Book] Book edited by Monika Gooz (2012)
  • Author(s): A Yoshihara
  • Publisher: Chronic Kidney Disease ISBN 979-953-307-048-2