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Oral care-induced activation and reproduction of the functional brain cognitive circuit in the elderly

Research Project

Project/Area Number 21390562
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

ONOZUKA Minoru  神奈川歯科大学, 歯学部, 教授 (90084780)

Co-Investigator(Kenkyū-buntansha) KANEMATSU Masayuki  岐阜大学, 医学部・附属病院, 准教授 (40252134)
TOMIDA Mihoko  松本歯科大学, 歯学部, 准教授 (00366329)
KUBO Kin-ya  星城大学, リハビリテーション学部, 教授 (00329492)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Keywords口腔ケア / 認知記憶 / 前頭前野 / MMSE / かな拾いテスト / fMRI / NIRS / 認知症 / 認知機能 / 光トポグラフィ / ブラッシング / 神経科学 / 脳の老化 / 痴呆 / 社会医学 / 老化 / 歯学
Research Abstract

We used neurocognitve tests, mini-mental status examination(MMSE) and Kana-hiroi test(KT), to investigate how oral care increases cognitive function in the elderly. Analysis using MMSE and KT revealed that oral care causes the correct answer rate in both tests, when compared with that in the absence of oral care. Furthermore, since oral care increases BOLD signals in the prefrontal cortex during KT performance, this care may be useful tool for enhancing cognitive function in the elderly via activation of the prefrontal cortex.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (12 results) Book (6 results) Remarks (3 results)

  • [Journal Article] Chewing ameliorates stress-induced suppression of spatial memory by increasing glucocorticoid receptor expression in the hippocampus2012

    • Author(s)
      Miyake S, Yoshikawa G, Yamada K, Sasaguri K, Yamamoto T, Onozuka M, Sato S
    • Journal Title

      Brain Res

      Volume: 1446 Pages: 34-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soft-food diet induces oxidative stress in the rat brain2011

    • Author(s)
      Ohno A, Yoshino F, Yoshida A, Hori N, Ono Y, Kimoto K, Onozuka M, Lee MC
    • Journal Title

      Neurosci Lett

      Volume: 508 Pages: 42-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chewing reduces sympathetic nervous response to stress and prevents poststress arrhythmias in rats2011

    • Author(s)
      Koizumi S, Minamisawa S, Sasaguri K, Onozuka M, Sato S, Ono Y
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 301

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parietal and temporal activity during a multimodal dance video game ; a fMRI study2011

    • Author(s)
      Tachibana A, Noah JA, Bronner S, Ono Y, Onozuka M
    • Journal Title

      Neurosci Lett

      Volume: 503 Pages: 125-30

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gender-related changes in three-dimensional microstructure of trabecular bone at the human proximal tibia with aging2011

    • Author(s)
      Chen Huayue, Washimi Y, Kubo K, Onozuka M
    • Journal Title

      Histol Histopathol

      Volume: 26 Pages: 563-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gadoxetate disodium-enhanced MR imaging : Differentiation between early-enhancing non-tumorous lesions and hypervascular hepatocellular carcinomas2011

    • Author(s)
      Goshima S, Kanematsu M, Watanabe H, Kondo H, Mizuno N, Kawada H, Shiratori Y, Onozuka M, Moriyama N, Bae KT
    • Journal Title

      Eur J Radiol

      Volume: 79 Pages: 108-12

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Staging hepatic fibrosis : comparison of gadoxetate disodium-enhanced and diffusion-weighted MR imaging-preliminary observations2011

    • Author(s)
      Watanabe H, Kanematsu M, Goshima S, Kondo H, Onozuka M, Moriyama N, Bae KT
    • Journal Title

      Radiology

      Volume: 259 Pages: 142-50

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CT of the pancreas : comparison of anatomic structure depiction, image quality, and radiation exposure between 320-detector volumetric images and 64-detector helical images2011

    • Author(s)
      Goshima S, Goshima S, Kanematsu M, Nishibori H, Sakurai K, Miyazawa D, Watanabe H, Kondo H, Shiratori Y, Onozuka M, Moriyama N, Bae KT
    • Journal Title

      Radiology

      Volume: 260 Pages: 139-47

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chewing-induced regional brain activity in edentulous patients who received mandibular implant-supported overdentures : a preliminary report2011

    • Author(s)
      Kimoto K, Ono Y, Tachibana A, Hirano Y, Otsuka T, Ohno A, Obata T, Onozuka M
    • Journal Title

      J Prosthodont Res

      Volume: 55 Pages: 89-97

    • NAID

      130004546608

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aortic and hepatic enhancement at multidetector CT : Evaluation of optimal iodine dose determined by lean body weight2011

    • Author(s)
      Kondo H, Kanematsu M, Goshima S, Watanabe H, Onozuka M, Moriyama N, Bae KT
    • Journal Title

      Eur J Radio

      Volume: 80

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chewing reduces sympathetic nervous response to stress and prevents poststress arrhythmias in rats2011

    • Author(s)
      S.Koizumi
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 301

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aortic and hepatic enhancement at multidetector GT : Evaluation of optimal iodine dose determined by lean body weight2011

    • Author(s)
      H.Kondo
    • Journal Title

      Eur J Radiol

      Volume: 80

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chewing-induced regional brain activity in edentulous patients who received mandibular implant-supported overdentures : a preliminary report2011

    • Author(s)
      小野塚実
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 55 Pages: 89-97

    • NAID

      130004546608

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occlusal disharmony suppresses long-term potentiation in the rat hippocampal CA1 region2011

    • Author(s)
      小野塚実
    • Journal Title

      Stomatology & Occlusion Medicine

      Volume: 3 Pages: 71-75

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occlusion and brain function : mastication as a prevention of cognitive dysfunction2010

    • Author(s)
      小野塚実
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 37 Pages: 624-640

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chewing rescues stress-suppressed hippocampal long-term potentiation via activation of histamine H1 receptor2009

    • Author(s)
      小野塚実
    • Journal Title

      Neuroscience Research 64

      Pages: 385-390

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drebrin(developmentally regulated brain protein)is associated with axo-somatic synapses and neuronal gap junctions in rat mesencephalic trigeminal nucleus2009

    • Author(s)
      小野塚実
    • Journal Title

      Neuroacience Letters 461

      Pages: 98-99

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection and grading for esophageal varices in patients with chronic liver damage : comparison of gadolinium-enhanced and unenhanced steady-state coherent MR images2009

    • Author(s)
      小野塚実
    • Journal Title

      Magnetic Resonance Imaging 27

      Pages: 1230-1235

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 咀嚼はワーキングメモリ課題遂行時の前頭前野と上側頭回の活動を促進する2012

    • Author(s)
      川本翔一, 川畑政綱, 木本克彦, 小野塚實, 小野弓絵
    • Organizer
      日本補綴歯科学会西関東支部会
    • Place of Presentation
      横浜
    • Year and Date
      2012-01-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Reduced mastication accelerates impairment of thehippocampal-dependent spatial learning ability of SAMP8 mice2011

    • Author(s)
      Kawahata M, Y Ono, Ohno A, Kawamoto S, Kimoto K, Onozuka M
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington
    • Year and Date
      2011-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Restoration of occlusion with implant-supported overdentures normalizes chewing-induced regional brain activity in edentulous patients2011

    • Author(s)
      Ono Y, Kimoto K, Tachibana A, Hirano Y, Otsuka T, Ohno A, Obata T, Onozuka M
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Chewing accelatates working memory acquisition in the prefrontal cortex and superior temporal gyrus2011

    • Author(s)
      Kawamoto S, Kawahata M, Onozuka M, Kimoto K, Ono Y
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 咀嚼は短期記憶課題遂行時の前頭前野活動を促進する:光トポグラフィーによる検討2011

    • Author(s)
      川本翔一, 川畑政綱, 木本克彦, 小野塚実, 小野弓絵
    • Organizer
      第34回日本神経科学学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] ストレスの緩和に及ぼすチューイングの効果-fMRIによる研究-2011

    • Author(s)
      水野潤造, 丹羽政美, 久保金弥, 湯山徳行, 小野塚實
    • Organizer
      第34回日本神経科学学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 認知記憶課題遂行に伴う前頭前野活動の咀嚼刺激による促進2011

    • Author(s)
      川本翔一, 小野弓絵, 川畑政綱, 木本克彦, 小野塚實
    • Organizer
      第13回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-02
    • Related Report
      2011 Final Research Report
  • [Presentation] FDG-PET imaging of the rat hypothalamus during stress-coping2010

    • Author(s)
      Ono Y, Lin HC, Chen HH, Tzen KY, Onozuka M, Yen CT
    • Organizer
      Society for Neuroscience 40th Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳賦活部位にみられるデンタルブラッシングの効果-fMRIによる研究-2010

    • Author(s)
      小野塚実
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chewing ameliorates sympathetic nervous response to stress and prevents arrhythmias2010

    • Author(s)
      Koizumi S, Ono Y, Sasaguri K, Sato S, Onozuka M
    • Organizer
      88th General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Barcelona
    • Year and Date
      2010-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Chewing counteracts stress-induced anxiety-like behavior by activating the dopaminergic system2010

    • Author(s)
      Ono Y, Fukui M, Koizumi S, Kawahata M, Onozuka M
    • Organizer
      88th General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Barcelona
    • Year and Date
      2010-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] ブラッシングによる高齢者の認知機能の増強効果2009

    • Author(s)
      小野塚実
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-07
    • Related Report
      2009 Annual Research Report
  • [Book] 噛むチカラでストレスに勝つ2011

    • Author(s)
      小野塚實
    • Publisher
      健康と良い友だち社
    • Related Report
      2011 Final Research Report
  • [Book] 噛めば脳が若返る2011

    • Author(s)
      小野塚實
    • Publisher
      PHP研究所
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 噛むチカラで肥満を防ぐ2010

    • Author(s)
      小野塚實
    • Publisher
      健康と良い友だち社
    • Related Report
      2011 Final Research Report
  • [Book] 噛むチカラでストレスに勝つ2010

    • Author(s)
      小野塚実
    • Total Pages
      127
    • Publisher
      健康と良い友だち社
    • Related Report
      2010 Annual Research Report
  • [Book] 噛むチカラで脳を守る2009

    • Author(s)
      小野塚實
    • Publisher
      健康と良い友だち社
    • Related Report
      2011 Final Research Report
  • [Book] 噛むチカラで脳を守る2009

    • Author(s)
      小野塚実
    • Total Pages
      125
    • Publisher
      健康と良い友だち社
    • Related Report
      2009 Annual Research Report
  • [Remarks] 咀嚼と脳の研究所

    • URL

      http://www.imbs-mastication.org/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.kdcnet.ac.jp/college/rcbos/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.imbs-mastication.org/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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