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Research for useful marineorganisms in Asia and Pacific regions

Research Project

Project/Area Number 21404010
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Living organism molecular science
Research InstitutionWaseda University

Principal Investigator

NAKAO Yoichi  早稲田大学, 理工学術院, 准教授 (60282696)

Co-Investigator(Renkei-kenkyūsha) HORI Kanji  広島大学, 生物圏科学研究科, 教授 (50116662)
SAKAI Ryuichi  北海道大学, 水産科学研究科, 教授 (20265721)
FUSETANI Nobuhiro  北海道大学, 水産科学研究科, 教授 (70012010)
MATSUOKA Shunji  早稲田大学, アジア太平洋研究科, 教授 (00211566)
FUKUZAWA Seketsu  東京大学, 理学系・研究科, 助教 (40321806)
WAKIMOTO Toshiyuki  東京大学, 薬学研究科, 講師 (70363900)
FUJITA Masaki  北海道大学, 水産科学研究科, 助教 (30505251)
TAKADA Kentarou  東京大学, 農学生命科学研究科, 助教 (90455353)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords海洋生物資源 / 天然物有機化学 / 生物活性物質
Research Abstract

In this project, a total 515 marine organisms were collected from 3 countries and preserved as the extract-, microbe-, and genome-libraries. Currently, evaluation for bioactivities of these extracts are being carried out. At the same time, thight collaborative relationship among the researchers of these countries and our group was founded, through this project.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (45 results)

All 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 5 results) Presentation (15 results) Book (8 results) Patent(Industrial Property Rights) (10 results) (of which Overseas: 8 results)

  • [Journal Article] The total synthesis and structure-activity relationships of a highly cytotoxic depsipeptide kulokekahilide-2 and its analogs2012

    • Author(s)
      Takada, Y.; Umehara, M.; Katsumata, R.; Nakao, Y.; Kimura, J.
    • Journal Title

      Tetrahedron

      Volume: 68 Pages: 659-669

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge2011

    • Author(s)
      Murayama, S.; Imae, Y.; Takada, K.; Kikuchi, J.; Nakao, Y.; van Soest, R. W. M.; Okada, S.; Matsunaga, S.
    • Journal Title

      Crella(Yvesia) spinulata Bioorg. Med. Chem

      Volume: 19 Pages: 6594-6598

    • Related Report
      2011 Final Research Report
  • [Journal Article] A One-pot Synthesis and Biological Activity of Ageladine A and Analogues2011

    • Author(s)
      Shengule, S. R.; Loa-Kum-Cheung, W. L.; Parish, C. R.; Blairvacq, M.; Meijer, L.; Nakao, Y.; Karuso, P.
    • Journal Title

      J. Med. Chem

      Volume: 54 Pages: 2492-2503

    • Related Report
      2011 Final Research Report
  • [Journal Article] Halenaquinone, a Chemical Compound That Specifically Inhibits the Secondary DNA Binding of RAD512011

    • Author(s)
      Takaku, M.; Kainuma, T.; Ishida, T.; Ishigami, S.; Suzuki, H.; Tashiro, S.; van Soest, R. W. M.; Nakao, Y.; Kurumizaka, H.
    • Journal Title

      Genes to Cells

      Volume: 16 Pages: 427-436

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata2011

    • Author(s)
      Murayama, S.; Imae, Y.; Takada, K.; Kikuchi, J.; Nakao, Y., et al
    • Journal Title

      Bioorg.Med.Chem.

      Volume: 19 Pages: 6594-6598

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A One-pot Synthesis and Biological Activity of Ageladine A and Analogues2011

    • Author(s)
      Shengule, S.R.; Nakao, Y.; Karuso, P., el al
    • Journal Title

      J.Med.Chem.

      Volume: 54 Pages: 2492-2503

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gracilioethers A-C, Anti-malarial Metabolites from the Marine Sponge2009

    • Author(s)
      Ueoka, R.; Nakao, Y.; Kawatsu, S.; Yaegashi, J.; Matsumoto, Y.; Matsunaga, S.; Furihata, K.; van Soest, R. W. M.; Fusetani, N.
    • Journal Title

      Agelas gracilis J. Org. Chem

      Volume: 74 Pages: 4204-4207

    • Related Report
      2011 Final Research Report
  • [Journal Article] Intramolecular Ester Exchange of Potent Cytotoxic Kulokekahilide-22009

    • Author(s)
      Umehara, M.; Takada, Y.; Nakao, Y.; Kimura, J.
    • Journal Title

      Tetrahedron Lett

      Volume: 50 Pages: 840-843

    • Related Report
      2011 Final Research Report
  • [Journal Article] A New Antiangiogenic C_<24> Oxylipin from the Soft Coral2009

    • Author(s)
      Yamashita, T.; Nakao, Y.; Matsunaga, S.; Oikawa, T.; Imahara, Y.; Fusetani, N.
    • Journal Title

      Sinularia numerosa Bioorg. Med. Chem

      Volume: 17 Pages: 2181-2184

    • Related Report
      2011 Final Research Report
  • [Journal Article] Gracilioethers A-C, Anti-malarial Metabolites from the Marine Sponge Agelas gracilis2009

    • Author(s)
      Ueoka, R., Nakao, Y., et al.
    • Journal Title

      J.Org.Chem. 74

      Pages: 4204-4207

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intramolecular Ester Exchange of Potent Cytotoxic Kulokekahilide-22009

    • Author(s)
      Umehara, M., Takada, Y., Nakao, Y., et al.
    • Journal Title

      Tetrahedron Lett. 50

      Pages: 840-843

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A New Antiangiogenic 024 Oxylipin from the Soft Coral Sinularia numerosa2009

    • Author(s)
      Yamashita, T., Nakao, Y., et al.
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 2181-2184

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 海洋生物由来のヒストン修飾制御剤の探索研究2012

    • Author(s)
      喜納惟斗、中尾洋一、木村宏、林陽子
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] DNA損傷機構に影響する化合物の探索2011

    • Author(s)
      中尾洋一
    • Organizer
      構造エピゲノム研究会第4回ワークショップ「DKA損傷とエピゲノム」
    • Place of Presentation
      横浜私立大(神奈川)(招待講演)
    • Year and Date
      2011-07-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA損傷機構に影響する化合物の探索2011

    • Author(s)
      中尾洋一
    • Organizer
      構造エピゲノム研究会第4回ワークショップ「DNA損傷とエピゲノム」
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] ケミカルスクリーニングに向けたハイスループットEGFシグナル検出プローブの開発2011

    • Author(s)
      田中順子、杉山結香、石上進太郎、吉野哲哉、中尾洋一、三輪佳宏
    • Organizer
      第34回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Anti-protozoan Agents from Marine Invertebrates2010

    • Author(s)
      Y Nakao, S Ishigami, Y Goto, S Kawazu, Y Matsumoto
    • Organizer
      PACIFICHEM2010
    • Place of Presentation
      Honolulu, Hawaii, USA(招待講演)
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anti-protozoan Agents from Marine Invertebrates2010

    • Author(s)
      Nakao, Y.; Ishigami, S.; Goto, Y.; Kawazu, S.; Matsumoto, Y.
    • Organizer
      2010環太平洋国際化学会議
    • Place of Presentation
      PACIFICHEM
    • Related Report
      2011 Final Research Report
  • [Presentation] 医薬品素材としての海洋天然化合物2010

    • Author(s)
      中尾洋一
    • Organizer
      富士山麓産学官金連携フォーラム2010
    • Place of Presentation
      沼津
    • Related Report
      2011 Final Research Report
  • [Presentation] 鹿児島県産海洋生物混獲物からの細胞毒性物質の単離と構造決定2010

    • Author(s)
      町田光史、中尾洋一
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] クロマチン構造をになうヌクレオソーム間相互作用のトランス制御因子2010

    • Author(s)
      須賀則之、吉河理与、中尾洋一、梅原崇史、横山茂之
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規RAD51組換え活性制御化合物の同定とその作用機序2010

    • Author(s)
      石田恭子、海沼嵩、高久誉大、鈴木秀和、田代聡、石上進太郎、中尾洋一、胡桃坂仁志
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of spectomycin B as the first SUMO E2 inhibitor2010

    • Author(s)
      Hirohama, M.; Ito, A.; Fukuda, I.; Igarashi, Y.; Saitoh, H.; Nakao, Y.; Yoshida, M.
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] 海綿由来の細胞毒性物質の探索研究2010

    • Author(s)
      勝俣良祐、中尾洋一
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 海洋生物由来の細胞毒性物質に関する研究2010

    • Author(s)
      前島寛、渡部裕喜、中尾洋一
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 海洋生物由来の抗リーシュマニア活性化合物に関する研究2010

    • Author(s)
      石上進太郎、中尾洋一
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 天然化合物を利用したケミカルエピゲノミクス研究の可能性について2009

    • Author(s)
      中尾洋一
    • Organizer
      大阪大学蛋白質研究所セミナー「疾患の基盤としてのエピジェネティクス」
    • Place of Presentation
      大坂
    • Related Report
      2011 Final Research Report
  • [Book] Enzyme Inhibitors from Maine Invertebrates, In Marine Natural Products Handbook2012

    • Author(s)
      Nakao, Y.; Fusetani, N.
    • Publisher
      Springer
    • Related Report
      2011 Final Research Report
  • [Book] Marine Natural Products Handbook2012

    • Author(s)
      Nakao, Y.; Fusetani, N.
    • Total Pages
      85
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report
  • [Book] 酵素阻害剤『マリンバイオテクノロジーの新展開』2011

    • Author(s)
      児玉公一郎・中尾洋一、伏谷伸宏
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] 海洋天然有機化合物が拓くケミカルバイオロジー2011

    • Author(s)
      児玉公一郎・中尾洋一
    • Related Report
      2011 Final Research Report
  • [Book] マリンバイオテクノロジーの新展開2011

    • Author(s)
      児玉公一郎・中尾洋一
    • Total Pages
      19
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Book] 早稲田大早産学連携レビュー112011

    • Author(s)
      児玉公一郎・中尾洋一
    • Total Pages
      3
    • Publisher
      日経BPムック
    • Related Report
      2011 Annual Research Report
  • [Book] Marine Invertebrates : Sponges. In Comprehensive Natural Products ; Chemistry II Chemistry and Biology2010

    • Author(s)
      Nakao, Y.; Fusetani, N.
    • Related Report
      2011 Final Research Report
  • [Book] Comprehensive Natural Products ; Chemistry II Chemistry and Biology2010

    • Author(s)
      Y Nakao, N Fusetani
    • Total Pages
      36
    • Publisher
      Elsevier
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] Biologically active compounds derived from marine organisms2012

    • Inventor(s)
      中尾洋一、町田光史、切替照雄
    • Industrial Property Rights Holder
      学校法人早稲田大学
    • Filing Date
      2012-01-30
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Biologically active compounds derived from marine organisms2012

    • Inventor(s)
      中尾洋一、町田光史、切替照雄
    • Industrial Property Rights Holder
      学校法人早稲田大学
    • Filing Date
      2012-01-30
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Novel Cyclic Depsipeptide and Use Thereof2011

    • Inventor(s)
      山下潤、中尾洋一、勝俣良祐
    • Industrial Property Rights Holder
      国立大学法人京都大学、学校法人早稲田大学
    • Filing Date
      2011-05-13
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 腔腸動物由来抗原虫化合物2011

    • Inventor(s)
      中尾洋一、石上進太郎、後藤康之、河津信一郎、井上昇
    • Industrial Property Rights Holder
      学校法人早稲田大学、国立大学法人帯広畜産大学
    • Filing Date
      2011-03-10
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Novel Cyclic Depsipeptide and Use Thereof2011

    • Inventor(s)
      山下潤、中尾洋一、勝俣良祐
    • Industrial Property Rights Holder
      国立大学法人京都大学、学校法人早稲田大学
    • Filing Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 腔腸動物由来抗原虫化合物2011

    • Inventor(s)
      中尾洋一、石上進太郎, ほか
    • Industrial Property Rights Holder
      早稲田大学、帯広畜産大学
    • Filing Date
      2011-03-10
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 新規環状デプシペプチドおよびその用途2010

    • Inventor(s)
      山下潤、中尾洋一、勝俣良祐
    • Industrial Property Rights Holder
      国立大学法人京都大学、学校法人早稲田大学
    • Filing Date
      2010-05-17
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 腔腸動物由来抗原虫化合物2010

    • Inventor(s)
      中尾洋一、石上進太郎、後藤康之、河津信一郎、井上昇
    • Industrial Property Rights Holder
      学校法人早稲田大学、国立大学法人帯広畜産大学
    • Industrial Property Number
      2010-055150
    • Filing Date
      2010-03-11
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 新規環状デブシペプチドおよびその用途2010

    • Inventor(s)
      山下潤、中尾洋一、勝俣良祐
    • Industrial Property Rights Holder
      京都大学、早稲田大学
    • Filing Date
      2010-05-17
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 腔腸動物由来抗原虫化合物2010

    • Inventor(s)
      中尾洋一, 石上進太郎, 他
    • Industrial Property Rights Holder
      学校法人早稲田大学, 他
    • Industrial Property Number
      2010-055150
    • Filing Date
      2010-03-11
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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