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Analysis on genetic, chemical and pharmacological diversity of medicinal plants, towards sustainable uses of traditional medicines

Research Project

Project/Area Number 21406004
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Environmental pharmacy
Research InstitutionUniversity of Toyama

Principal Investigator

KOMATSU Katsuko  富山大学, 和漢医薬学総合研究所, 教授 (50225570)

Co-Investigator(Kenkyū-buntansha) TANAKA Ken  富山大学, 和漢医薬学総合研究所, 准教授 (60418689)
TOHDA Chihiro  富山大学, 和漢医薬学総合研究所, 准教授 (10272931)
SHIBAHARA Naotoshi  富山大学, 和漢医薬学総合研究所, 教授 (10272907)
Co-Investigator(Renkei-kenkyūsha) ZHU Shu  富山大学, 和漢医薬学総合研究所, 助教 (20377360)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords薬用植物 / 分子系統学 / 品質評価 / 認知症 / 生活習慣病 / 刺五加 / 中国 / 芍薬 / 国際研究者交流
Research Abstract

Eleutheroside B contained in rhizome of Eleutherococcus senticosus and root bark of Acanthopanax gracilistylus showed protective effect against neuritic atrophy in vitro and amelioration of the impaired object identification memory in vivo, suggesting that both herbal drugs would be expected for the application in dementia remedy. Among Acorus species whose rhizomes showed neurite outgrowth activity, some genotype of A. gramineus with low amount ofβ-asarone, a carcinogenic compound, were found. Based on genetic and chemical evidences, the botanical sources of white and red peony roots from China were demonstrated to be the southern and northern strains of Paeonia lactiflora, respectively, and several horticultural varieties were selected as alternative medicinal resources. Above results will contribute to sustainable uses of such medicinal resources.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (46 results)

All 2012 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (27 results) Remarks (7 results)

  • [Journal Article] Active components from Siberian ginseng(Eleutherococcus senticosus) for protection of amyloidβ(25-35)-induced neuritic atrophy in cultured rat cortical neurons2011

    • Author(s)
      Bai Y. J., Tohda C., Zhu S., Hattori M., Komatsu K.
    • Journal Title

      J. Nat. Med.

      Volume: 65 Pages: 417-423

    • NAID

      10029461713

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and chemical diversity of Eleutherococcus senticosus and molecular identification of Siberian ginseng by PCR-RFLP analysis based on chloroplast trnK intron sequence2011

    • Author(s)
      Zhu S., Bai Y. J., Oya M., Tanaka K., Komatsu K.
    • Journal Title

      Food Chemistry

      Volume: 129 Pages: 1844-1850

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic diversity of Ephedra plants in Mongolia inferred from internal transcribed spacer sequence of nuclear ribosomal DNA2011

    • Author(s)
      Kitani Y., Zhu S., Batkhuu J., Sanchir C., Komatsu K.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 34 Pages: 717-726

    • NAID

      130000657786

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cinnamaldehide and paeonol increase HIF-1αactivity in proximal tubular epithelial cells under hypoxia2011

    • Author(s)
      Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., Shimada Y.
    • Journal Title

      J. Trad. Med.

      Volume: 28 Pages: 149-157

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in culturedrat cortical neurons2011

    • Author(s)
      Bai Y.J., Tohda C, Zhu S., Hattori M., Komatsu K.
    • Journal Title

      J.Nat.Med.

      Volume: 65 Issue: 3-4 Pages: 417-423

    • DOI

      10.1007/s11418-011-0509-y

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic diversity of Ephedra plants in Mongolia inferred from internal transcribed spacer sequence of nuclear ribosomal DNA2011

    • Author(s)
      Kitani Y., Zhu S., Batkhuu J.,Sanchir C., Komatsu K.
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 34 Pages: 717-726

    • NAID

      130000657786

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetioc variation of Croton stellatopilosus Ohba based on non-coding DNA sequences of ITS, trnK and trnL-F regions2011

    • Author(s)
      Rinthong P.O., Zhu S., Komatsu K., Chanama S., De-Eknamkul W.
    • Journal Title

      J.Nat.Med.

      Volume: 65 Issue: 3-4 Pages: 641-645

    • DOI

      10.1007/s11418-011-0536-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The C-Glucosyl Bond of Puerarin Was Cleaved Hydrolytically by a Human Intestinal Bacterium Strain PUE to Yield Its Aglycone Daidzein and an Intact Glucose2011

    • Author(s)
      Nakamura K., Nishihata T.,Jin J.S., Ma CM., Komatsu K.,Iwashima M., Hattori M.
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 59 Issue: 1 Pages: 23-27

    • DOI

      10.1248/cpb.59.23

    • NAID

      130000405483

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curdione plays an important role in the inhibitory effect of Curcuma aromatica on CYP3A4 in Caco-2 cells2011

    • Author(s)
      Hou X.L., Hayashi E., Takatani-Nakase T., Tanaka K., Takahashi K., Komatsu K., Takahashi K.
    • Journal Title

      Evid.Based Complement.Altemat.Med.

      Volume: 2011 Issue: 1

    • DOI

      10.1093/ecam/nep229

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cinnamaldehide and paeonol increase HIF-1α activity in proximal tubular epithelial cells under hypoxia2011

    • Author(s)
      Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., Shimada Y.
    • Journal Title

      J.Trad.Med.

      Volume: 28 Pages: 149-157

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic diversity of Ephedra plants in Mongolia inferred from nrDNAITS sequence2011

    • Author(s)
      Kitani Y., Zhu S., Batkhuu J., Sanchir C., Komatsu K.
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 34(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Authentication of Curcuma species (Zingiberaceae) based on nuclear 18S rDNA and plastid trnK sequences2010

    • Author(s)
      Cao H., Sasaki Y., Fushimi H., Komatsu K.
    • Journal Title

      Yao Xue Xue Bao

      Volume: 45 Pages: 926-933

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腸内細菌由来プエラリンC-配糖体代謝酵素の精製2012

    • Author(s)
      中村賢一, 小松かつ子, 服部征雄, 岩島誠
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 当帰芍薬散:伝統的剤形の有用性と原料生薬の品質2011

    • Author(s)
      島田佳代子, 中村勇斗, 川瀬雅也, 柴原直利, 小松かつ子, 高橋京子
    • Organizer
      平成23年度日本東洋医学会関西支部例会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2011-10-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Quantitation of Curcuminoids in Curcuma Rhizome by Near-infrared Spectroscopic Analysis2011

    • Author(s)
      Tanaka K., Komatsu K.
    • Organizer
      The 2nd International Symposium on Temulawak and The 40th Meeting of National Working Group on Indonesian Medicinal Plant
    • Place of Presentation
      Bogor, Indonesia
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular identification of Salacia plants and the related crude drugs based on DNA sequence of two non-coding regions2011

    • Author(s)
      Zhu S., He J. Y., Komatsu K., Samarakoon S. P., Nagatomo A., Nishida N., Matsuura Y.
    • Organizer
      The 6th JSP-CCTCNM-KSP International Conference on Pharmacognosy
    • Place of Presentation
      Shengyang, China
    • Related Report
      2011 Final Research Report
  • [Presentation] Genetic, chemical and pharmacological diversity of Ginseng drugs2011

    • Author(s)
      Komatsu K., Zhu S.
    • Organizer
      The 10th Annual Oxford International Conference on the Science of Botanicals
    • Place of Presentation
      Mississippi Univ.(Oxford, USA)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Quantitation of Curcuminoids in Curcuma Rhizome by Near-infrared Spectroscopic Analysis2011

    • Author(s)
      Tanaka K., Komatsu K.
    • Organizer
      The 2nd International Symposium on Temulawak and The 40th Meeting of National Working Group on Indonesian Medicinal Plant
    • Place of Presentation
      Bogor Agricultural Univ.(Bogor, Indonesia)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic, chemical and pharmacological diversity of Ginseng drugs2011

    • Author(s)
      Komatsu K., Zhu S., Tohda C.
    • Organizer
      The 6th JSP-CCTCNM-KSP International Conference on Pharmacognosy
    • Place of Presentation
      Shengyang Pharmaceutical Univ. (Shengyang, China)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular identification of Salacia plants and the related crude drugs based on DNA sequence of two non-coding regions2011

    • Author(s)
      Zhu S., He J.Y., Komatsu K., Samarakoon S.P., Nagatomo A., Nishida N., Matsuiira Y.
    • Organizer
      The 6th JSP-CCTCNM-KSP International Conference on Pharmacognosy
    • Place of Presentation
      Shengyang Pharmaceutical Univ. (Shengyang, China)
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウスにおける抗癌薬誘発疼痛に対する5種類の漢方方剤の薬効評価2011

    • Author(s)
      北村亮, 安東嗣修, 伏見裕利, 小松かつ子, 柴原直利
    • Organizer
      第28回和漢医薬学会学術大会
    • Place of Presentation
      富山県民会館(富山)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「伝統医薬データベース」の構築2011

    • Author(s)
      柴原直利, 東田千尋, 朱〓, 櫻井宏明, 数馬恒平, 山本武, 小泉桂一, 紺野勝弘, 門脇真, 小松かつ子
    • Organizer
      第28回和漢医薬学会学術大会
    • Place of Presentation
      富山県民会館(富山)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 漢薬「麻黄」の資源探索:モンゴル国産Ephedra属植物の遺伝子多型とアルカロイド成分に関する研究2011

    • Author(s)
      朱〓, 木谷友紀, 小松かつ子
    • Organizer
      第28回和漢医薬学会学術大会
    • Place of Presentation
      富山県民会館(富山)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高脂肪食負荷ラットに対する和漢薬の効果についての検討2011

    • Author(s)
      藤本孝子, 亀井貴志, 条美智子, 後藤博三, 嶋田豊, 柴原直利
    • Organizer
      第28回和漢医薬学会学術大会
    • Place of Presentation
      富山県民会館(富山)
    • Related Report
      2011 Annual Research Report
  • [Presentation] フィールド調査の成果を収納し実践に移す場となる民族薬物資料館2011

    • Author(s)
      小松かつ子
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      昭和大学(東京)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ウコン属植物のクルクミノイド生合成酵素遺伝子イントロン多型の比較2011

    • Author(s)
      喜多智子, 正村典也, 小松かつ子, 朱〓, 飯田修, 杉村康司
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      昭和大学(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生薬「マオウ」の簡易同定法の開発とモンゴル国栽培品E.sinicaの品質評価及び栽培条件の検討2011

    • Author(s)
      木谷友紀, 朱〓, 田中謙, 小松かつ子, 辰尾良秋, Batkhuu J
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      昭和大学(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 党参の基原と品質に関する研究(3)-Codonopsis属植物及党参のITS領域の塩基配列2011

    • Author(s)
      何敬愉, 朱〓, 小松かつ子, 合田幸広, 神谷洋, 横倉胤夫
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      昭和大学(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Active components of Siberian ginseng for protection of amyloidβ(25-35)-induced neuritic atrophy in cultured cortical neurons2010

    • Author(s)
      Bai Y. J., Zhu S., Tohda C., Komatsu K.
    • Organizer
      日本薬学会北陸支部第122回例会
    • Place of Presentation
      金沢
    • Year and Date
      2010-11-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Active components of Siberian ginseng for protection of amyloid β (25-35)-induced neuritic atrophy in cultured cortical neurons2010

    • Author(s)
      Bai Y.J., Zhu S., Tohda C., Komatsu K.
    • Organizer
      日本薬学会北陸支部第122回例会
    • Place of Presentation
      北陸大学薬学部(金沢)
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] モンゴルEphedra属植物の核ITS1領域の配列解析2010

    • Author(s)
      木谷友紀, 朱妹, Batkhuu J., Sanchir C., 小松かつ子
    • Organizer
      日本薬学会北陸支部第122回例会
    • Place of Presentation
      北陸大学薬学部(金沢)
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Standardization of herbal drugs and health foods related to genus Curcuma2010

    • Author(s)
      Komatsu K.
    • Organizer
      International Symposium on Oriental Fermented Medicine
    • Place of Presentation
      清風リゾート(Jechon, Korea)
    • Year and Date
      2010-09-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 芍薬の成分的多様性の解析2010

    • Author(s)
      呉〓秋, 朱妹, 小松かつ子, 村上守一, 田中彰雄, 柴田敏郎
    • Organizer
      第27回和漢医薬学会学術大会
    • Place of Presentation
      京都薬科大学(京都)
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食事誘発性糖尿病モデルラットに対する和漢薬の効果2010

    • Author(s)
      亀井貴志, 藤本孝子, 条美智子, 木村真梨, 金子真利亜, 後藤博三, 嶋田豊, 柴原直利
    • Organizer
      第27回和漢医薬学会学術大会
    • Place of Presentation
      京都薬科大学(京都)
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 党参の基原と品質に関する研究(1)-Codonopsis属植物及び党参のITS領域の塩基配列について2010

    • Author(s)
      朱?, 陳芳清, 佐藤杏子, 合田幸広, 小松かつ子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of Acori Graminei Rhizoma on Aβ(25-35)-induced atrophies of axons and dendrites2010

    • Author(s)
      Bai Y. J., Zhu S., Tohda C., Komatsu K.
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 芍薬の成分的多様性の解析2010

    • Author(s)
      呉〓秋,小松かつ子,村上守一,田中彰雄,柴田敏郎
    • Organizer
      第27回和漢医薬学会学術大会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 党参の基に関する(2)-Codonopsis属植物及び党のITS領域の塩基配列について2010

    • Author(s)
      何敬愉, 朱妹, 小松かつ子, 合田幸広
    • Organizer
      日本生薬学会第57年会
    • Place of Presentation
      徳島文理大学(徳島)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 芍薬の遺伝的多様性の解析2009

    • Author(s)
      白石史遠, 小松かつ子, Zhu S, 村上守一, 田中彰雄, 柴田敏郎
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.inm.u-toyama.ac.jp/pharmacognosy/index-j.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.inm.u-toyama.ac.jp/jp/departments/01_pharmacognosy.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.inm.u-toyama.ac.jp/pharmacognosy/index-j.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.inm.u-toyama.ac.jp/jp/departments/01_pharmacognosy.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.inm.u-toyama.ac.jp/pharmacognosy/research/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.inm.u-toyama.ac.jp/jp/departments/01_pharmacognosy.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.inm.u-toyama.ac.jp/pharmacognosy/studies/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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