Analysis on genetic, chemical and pharmacological diversity of medicinal plants, towards sustainable uses of traditional medicines
| Project/Area Number |
21406004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Environmental pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
KOMATSU Katsuko 富山大学, 和漢医薬学総合研究所, 教授 (50225570)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Ken 富山大学, 和漢医薬学総合研究所, 准教授 (60418689)
TOHDA Chihiro 富山大学, 和漢医薬学総合研究所, 准教授 (10272931)
SHIBAHARA Naotoshi 富山大学, 和漢医薬学総合研究所, 教授 (10272907)
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| Co-Investigator(Renkei-kenkyūsha) |
ZHU Shu 富山大学, 和漢医薬学総合研究所, 助教 (20377360)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 薬用植物 / 分子系統学 / 品質評価 / 認知症 / 生活習慣病 / 刺五加 / 中国 / 芍薬 / 国際研究者交流 |
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| Research Abstract |
Eleutheroside B contained in rhizome of Eleutherococcus senticosus and root bark of Acanthopanax gracilistylus showed protective effect against neuritic atrophy in vitro and amelioration of the impaired object identification memory in vivo, suggesting that both herbal drugs would be expected for the application in dementia remedy. Among Acorus species whose rhizomes showed neurite outgrowth activity, some genotype of A. gramineus with low amount ofβ-asarone, a carcinogenic compound, were found. Based on genetic and chemical evidences, the botanical sources of white and red peony roots from China were demonstrated to be the southern and northern strains of Paeonia lactiflora, respectively, and several horticultural varieties were selected as alternative medicinal resources. Above results will contribute to sustainable uses of such medicinal resources.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Cinnamaldehide and paeonol increase HIF-1αactivity in proximal tubular epithelial cells under hypoxia2011
Author(s)
Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., Shimada Y.
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Journal Title
J. Trad. Med.
Volume: 28
Pages: 149-157
Related Report
Peer Reviewed
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[Journal Article] Cinnamaldehide and paeonol increase HIF-1α activity in proximal tubular epithelial cells under hypoxia2011
Author(s)
Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., Shimada Y.
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Journal Title
J.Trad.Med.
Volume: 28
Pages: 149-157
Related Report
Peer Reviewed
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[Presentation] 「伝統医薬データベース」の構築2011
Author(s)
柴原直利, 東田千尋, 朱〓, 櫻井宏明, 数馬恒平, 山本武, 小泉桂一, 紺野勝弘, 門脇真, 小松かつ子
Organizer
第28回和漢医薬学会学術大会
Place of Presentation
富山県民会館(富山)
Related Report
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[Presentation] 芍薬の成分的多様性の解析2010
Author(s)
呉〓秋, 朱妹, 小松かつ子, 村上守一, 田中彰雄, 柴田敏郎
Organizer
第27回和漢医薬学会学術大会
Place of Presentation
京都薬科大学(京都)
Year and Date
2010-08-29
Related Report
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[Presentation] 芍薬の遺伝的多様性の解析2009
Author(s)
白石史遠, 小松かつ子, Zhu S, 村上守一, 田中彰雄, 柴田敏郎
Organizer
日本薬学会第129年会
Place of Presentation
京都
Year and Date
2009-03-28
Related Report
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