Networking for research on human genetics of Tuberculosis

• Project/Area Number: 21406006
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Human genetics
• Research Institution: The University of Tokyo
• Principal Investigator: TOKUNAGA Katsushi 東京大学, 大学院・医学系研究科, 教授 (40163977)
• Co-Investigator(Kenkyū-buntansha): MABUCHI Akihiko 東京大学, 大学院・医学系研究科, 准教授 (80312312) ; SHIBUYA Kenji 東京大学, 大学院・医学系研究科, 教授 (50322459)
• Co-Investigator(Renkei-kenkyūsha): YANAI Hideki 東京大学, 大学院・医学系研究科, 客員研究員 (60437845)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 遺伝学 / 感染症 / 結核 / ゲノム / 関連遺伝子 / 国際共同研究 / タイ / インドネシア / 遣伝学 / トランスレーショナル・リサーチ

Research Abstract

Tuberculosis(TB) is one of three major infectious diseases, affecting billions of people worldwide. Genome-wide association analyses in Thais and Japanese were carried out. The result of meta-analysis of young tuberculosis, an age subset GWAS was conducted in Thai and Japanese populations and a risk locus for young TB on 20q12 was identified. While the locus is located far from coding regions, the genes(HSPEP1-MAFB) close to this locus are promising candidates for tuberculosis susceptibility. We have collected samples based on our research network in Thailand, Japan, and Indonesia including age and pathogen information, which may accelerate the identification of the distinct host factors of TB.

Research Products

• [Journal Article] Genome-wide association studies of tuberculosis in Asians (2012)
  • Author(s): Mahasirimongkol S, Yanai H, Mushiroda T, Promphittayarat W, Wattanapokayakit S, Promjai J, Yuliwulandari R, Wichukchinda N, Yowang A, Yamada N, Kantipong P, Takahashi A, Kubo M, Sawanpanyalert P, Kamatani N, Nakamura Y, Tokunaga K
  • Journal Title: Journal of Human Genetics Volume: 57巻(6) Issue: 6 Pages: 363-367
  • DOI: 10.1038/jhg.2012.35
  • Peer Reviewed
• [Journal Article] Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis (2012)
  • Author(s): Mahasirimongkol S, Yanai H, Mushiroda T, Promphittayarat W, Wattanapokayakit S, Promjai J, Yuliwulandari R, Wichukchinda N, Yowang A, Yamada N, Kantipong P, Takahashi A, Kubo M, Sawanpanyalert P, Kamatani N, Nakamura Y, Tokunaga K
  • Journal Title: Journal of Human Genetics Volume: 57(提載確定)(印刷中)
  • NAID: 10030808016
  • Peer Reviewed
• [Journal Article] Association of TLR polymorphisms with development of tuberculosis in Indonesian females (2011)
  • Author(s): Kobayashi K, Yuliwulandari R, Yanai H, Naka I, Lien LT, Hang NT, Hijikata M, Keicho N
  • Journal Title: Tissue Antigens 2012 Mar Volume: 79(3) Issue: 3 Pages: 190-197
  • DOI: 10.1111/j.1399-0039.2011.01821.x
  • Peer Reviewed
• [Journal Article] Association of CD209 polymorphisms with tuberculosis in an Indonesian population (2011)
  • Author(s): Kobayashi K, Yuliwulandari R, Yanai H, Lien LT, Hang NT, Hijikata M, Keicho N, Tokunaga K.
  • Journal Title: Human Immunology 2011 Sep Volume: 72(9) Issue: 9 Pages: 741-745
  • DOI: 10.1016/j.humimm.2011.04.004
  • Peer Reviewed
• [Journal Article] Association of CD209 polymorphisms with tuberculosis in an Indonesian population (2011)
  • Author(s): Kobayashi K, Yuliwulandari R, Yanai H, Lien LT, Hang NT, Hijikata M, Keicho N, Tokunaga K
  • Journal Title: Human Immunology Volume: 72 Pages: 741-745
  • Peer Reviewed
• [Journal Article] Association analysis of susceptibility candidate region on chromosome 5q31-33for tuberculosis (2010)
  • Author(s): Ridruechai C, Mahasirimongkol S, Promjai J, Yanai H, Nishida N, Matsushita I, Ohashi J, Yamada N, Moolphate S, Summanapan S, Chuchotaworn C, Manosuthi W, Kantipong P, Kanitwittaya S, Sawanpanyalert P, Keicho N, Khusmith S, Tokunaga K
  • Journal Title: Genes and Immunity Volume: 11(5) Issue: 5 Pages: 416-422
  • DOI: 10.1038/gene.2010.26
  • Peer Reviewed
• [Journal Article] Association of HLA-A,-B, and-DRB1 with pulmonary tuberculosis in western Javanese Indonesia (2010)
  • Author(s): Yuliwulandari R, Sachrowardi Q, Nakajima F, Kashiwase K, Hirayasu K, Mabuchi A, Salam A M, Tokunaga K
  • Journal Title: Human Immunology Volume: 71(7) Issue: 7 Pages: 697-701
  • DOI: 10.1016/j.humimm.2010.04.005
  • Peer Reviewed
• [Journal Article] Association analysis of susceptibility candidate region on chromosome 5q31-33 for tuberculosis. (2010)
  • Author(s): Ridruechai C, Mahasirimongkol S, Promjai J, et al.
  • Journal Title: Genes and Immunity Volume: 11(5) Pages: 416-422
  • Peer Reviewed
• [Journal Article] Association of HLA-A,-B, and-DRB1 with pulmonary tuberculos is in western Javanese Indonesia. (2010)
  • Author(s): Yuliwulandari R, Sachrowardi Q, Nakajima H, et al.
  • Journal Title: Human Immunology Volume: 71(7) Pages: 697-701
  • Peer Reviewed
• [Journal Article] Association analysis of susceptibility candidate region on chromosome 5q31-33 for tuberculosis.
  • Author(s): Ridruechai C, Mahasirimongkol S, Promjai J, et al.
  • Journal Title: Genes and Immunity ((印刷中)掲載確定) Pages: 2010-2010
  • Peer Reviewed
• [Presentation] Genome-wide association studies of tuberculosis in East Asians identify distinct at-risk locus for young tuberculosis (2011)
  • Author(s): 徳永勝士、Surakameth Mahasirimongkol、野内英樹、莚田泰成、Watoo Promphittayasatit、Sukanya Pokayawattanakit、Jurairut Phromjai、Rika Yuliwandalari、Nuanjun Wichukchinda、Amara Yowang、山田紀男、Pacharee Kantipong、高橋篤、久保充明、Pathom Sawanpanyalert、鎌谷直之、中村裕輔
  • Organizer: 第56回日本人類遺伝学会(口頭演題0-076)
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-11
• [Presentation] Genome-wide association studies of tuberculosis in East Asians identify distinct at-risk locus for young tuberculosis (2011)
  • Author(s): 徳永勝士, Surakameth Mahasirimongkol, 野内英樹,莚田泰成, et al.
  • Organizer: 第56回日本人類遺伝学会
  • Place of Presentation: 幕張メッセ(千葉県千葉市)
  • Year and Date: 2011-11-11
• [Presentation] 17番染色体上の機能的及び位置的候補遺伝子と結核の関連解析第20回日本組織適合性学会 (2011)
  • Author(s): 中内彩香、Rika Yuliwulandari、Surakameth Mahasirimongkol、野内英樹、徳永勝士
  • Organizer: 一般ポスター演題P20
  • Place of Presentation: ツインメッセ静岡(静岡県)
• [Presentation] EFFECT OF AGE SUBSET ON GENOME-WIDE ASSOCIATION ANALYSIS OF TUBERCULOSIS IN THAIS 5th Human Genome Meeting (2011)
  • Author(s): 徳永勝士
  • Place of Presentation: アラブ首長国連盟(ドバイ)
• [Presentation] Candidate gene association analysis of single nucleotide polymorphism in NEMO with tuberculosis in Thailand Keystone Symposia Global Health Series (2011)
  • Author(s): Sukanya Wattanapokayakit, Surakameth Mahasirimongkol, Jurairut Phromjai, Amara Yowang, Watoo Promphittayasatit, Nuanjun Wichukchinda, Nusara Satproedprai, Wimala In-Unchot, Pathom Sawanpanyalert, Hideki Yanai, Taisei Mushiroda, Katsushi Tokunaga, Yusuke Nakamura
  • Organizer: Tuberculosis : Immunology, Cell Biology and Novel Vaccination Strategies
  • Place of Presentation: Vancouver, British Columbia, Canada
• [Presentation] Effect of age subset on genome-wide association analysis of tuberculosis in Thais (2011)
  • Author(s): Mahasirimongkol S, et al.
  • Organizer: Human Genome Meeting 2011
  • Place of Presentation: ドバイ国際会議・展示センター(ドバイ、アラブ首長国連邦)
• [Presentation] タイと日本における菌体と人検体の長期縦断的検体バンクによる結核の発症と難治化に関する要因研究 (2010)
  • Author(s): 野内英樹、出井禎
  • Organizer: 第57回日本臨床検査医学会学術集会(一般口頭演題、微生物検査(2)演題番号0-66)
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-09-10
• [Presentation] 東南アジア系集団における結核感受性とCD209遺伝子の関連 (2010)
  • Author(s): 小林杏輔、Rika Yuliwulandari、慶長直人、Nguyen Thi Le Hang、徳永勝士
  • Organizer: 第55回日本人類遺伝学会
  • Place of Presentation: 大宮ソニックシテイ(埼玉県)
• [Presentation] Pathom Sawanpanyalert, Naoto Keicho Genome-wide SNP-based linkage analysis of tuberculosis in Thais (2009)
  • Author(s): Surakameth Mahasirimongkol, Hideki Yanai, Nao Nishida, Chutharut Ridruechai, Ikumi Matsushita, Jun Ohashi, Surin Summanapan, Norio Yamada, Saiyud Moolphate, Charoen Chuchotaworn, Angkana Chaiprasert, Weerawat Manosuthi, Pacharee Kantipong, Sangkom Kanitwittaya, Thanyachai Sura, Srisin Khusmith, Katsushi Tokunaga
  • Organizer: 第84回日本結核病学会総会(シンポジウムII結核における宿主遺伝要因研究の現状と展望演題4)
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2009-07-02
• [Presentation] Genome-wide SNP-based linkage analysis of tuberculosis in Thais (2009)
  • Author(s): スラカメ・マハシリモンコル
  • Organizer: 第84回日本結核病学会総会・シンポジウム
  • Place of Presentation: 札幌市 札幌コンベンションセンター
  • Year and Date: 2009-07-02