| Project/Area Number |
21406006
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Human genetics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MABUCHI Akihiko 東京大学, 大学院・医学系研究科, 准教授 (80312312)
SHIBUYA Kenji 東京大学, 大学院・医学系研究科, 教授 (50322459)
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| Co-Investigator(Renkei-kenkyūsha) |
YANAI Hideki 東京大学, 大学院・医学系研究科, 客員研究員 (60437845)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 遺伝学 / 感染症 / 結核 / ゲノム / 関連遺伝子 / 国際共同研究 / タイ / インドネシア / 遣伝学 / トランスレーショナル・リサーチ |
|---|
| Research Abstract |
Tuberculosis(TB) is one of three major infectious diseases, affecting billions of people worldwide. Genome-wide association analyses in Thais and Japanese were carried out. The result of meta-analysis of young tuberculosis, an age subset GWAS was conducted in Thai and Japanese populations and a risk locus for young TB on 20q12 was identified. While the locus is located far from coding regions, the genes(HSPEP1-MAFB) close to this locus are promising candidates for tuberculosis susceptibility. We have collected samples based on our research network in Thailand, Japan, and Indonesia including age and pathogen information, which may accelerate the identification of the distinct host factors of TB.
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