Geographic pathology of HBV-related hepatitis and liver cancers based on characterization of HBV genome variant
| Project/Area Number |
21406007
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Human pathology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
ABE Kenji 国立感染症研究所, 感染病理部, 主任研究官 (60130415)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | アジア / 国際連携 / 国際研究 / B型肝炎ウイルス(HBV) / ウイルス肝炎 / ウイルス肝癌 / 地理病理学 / 分子疫学 / ウイルスゲノタイプ / ウイルス変異株 / 肝癌 / 小児肝癌 / 東南アジア / ベトナム / 台湾 / B型肝炎 / HBV / 胆管癌 / 台湾アボリジン |
|---|
| Research Abstract |
(1) HBV DNA in HCC tissues from children patients was detected in 36 of 42 (86%) cases tested. Surprisingly, very high prevalence of HBV pre-S deletion mutant was recognized in 27 of 30 (90%) HCCs examined. Interestingly, the pre-S2 mutant consistently appeared with deletion at nt 4-57 in all of the 20 cases with pre-S2 mutant (100%). This hot spot mutation in the pre-S2 was further confirmed by complete genomic sequence of HBV in a Japanese boy who eventually developed HCC.
(2) We identified a novel subgenotype HBV/D10 in Taiwanese aborigine HBV carriers.
(3) HBV infection appears to be associated with the pathogenesis of intrahepatic cholangiocarcinoma (ICC) in northern China. The high fatality rate of cholangiocarcinoma intensifies the need for further research to understand the precise mechanism of HBV infection and the development of ICC.
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Report
(5 results)
Research Products
(37 results)
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[Journal Article] Eight novel hepatitis C virus genomes reveal the changing taxonomic structure of genotype 6.2013
Author(s)
Wang H, Yuan Z, Barnes E, Yuan M, Li C, Fu Y, Xia X, Li G, Newton P, Vongsouvath M, Klenerman P, Pybus OG, Murphy D, Abe K, Lu L
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Journal Title
Journal of General Virology
Volume: 94
Issue: 1
Pages: 76-80
DOI
Related Report
Peer Reviewed
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[Journal Article] HCV 6a prevalence in guangdong province had the origin from Vietnam and recent dissemination to other regions of China: Phylogeographic analyses.2012
Author(s)
Yongshui Fu, Weibing Qin, Hong Cao, Ru Xu, Yi Tan, Teng Lu, Hongren Wang, Wangxia Tong, Xia Rong, Gang Li, Manqiong Yuan, Chunhua Li, Kenji Abe, Ling Lu
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Journal Title
PLoS One
Volume: 7
Issue: 1
Pages: e28006-e28006
DOI
Related Report
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