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Geographic pathology of HBV-related hepatitis and liver cancers based on characterization of HBV genome variant

Research Project

Project/Area Number 21406007
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Human pathology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

ABE Kenji  国立感染症研究所, 感染病理部, 主任研究官 (60130415)

Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywordsアジア / 国際連携 / 国際研究 / B型肝炎ウイルス(HBV) / ウイルス肝炎 / ウイルス肝癌 / 地理病理学 / 分子疫学 / ウイルスゲノタイプ / ウイルス変異株 / 肝癌 / 小児肝癌 / 東南アジア / ベトナム / 台湾 / B型肝炎 / HBV / 胆管癌 / 台湾アボリジン
Research Abstract

(1) HBV DNA in HCC tissues from children patients was detected in 36 of 42 (86%) cases tested. Surprisingly, very high prevalence of HBV pre-S deletion mutant was recognized in 27 of 30 (90%) HCCs examined. Interestingly, the pre-S2 mutant consistently appeared with deletion at nt 4-57 in all of the 20 cases with pre-S2 mutant (100%). This hot spot mutation in the pre-S2 was further confirmed by complete genomic sequence of HBV in a Japanese boy who eventually developed HCC.
(2) We identified a novel subgenotype HBV/D10 in Taiwanese aborigine HBV carriers.
(3) HBV infection appears to be associated with the pathogenesis of intrahepatic cholangiocarcinoma (ICC) in northern China. The high fatality rate of cholangiocarcinoma intensifies the need for further research to understand the precise mechanism of HBV infection and the development of ICC.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (37 results)

All 2013 2012 2011 2010 2009

All Journal Article (15 results) (of which Peer Reviewed: 6 results) Presentation (20 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Eight novel hepatitis C virus genomes reveal the changing taxonomic structure of genotype 6.2013

    • Author(s)
      Wang H, Yuan Z, Barnes E, Yuan M, Li C, Fu Y, Xia X, Li G, Newton P, Vongsouvath M, Klenerman P, Pybus OG, Murphy D, Abe K, Lu L
    • Journal Title

      Journal of General Virology

      Volume: 94 Issue: 1 Pages: 76-80

    • DOI

      10.1099/vir.0.047506-0

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The response to interferon is influenced by hepatitis B virus genotype in vitro and in vivo.2013

    • Author(s)
      Zhang Y, Wu Y, Ye S, Wang T, Zhao R, Chen F, Abe K, Jin X
    • Journal Title

      Virus Research

      Volume: 171 Pages: 65-70

    • URL

      http://dx.doi.org/10.1016/j.virusres.2012.10.027

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Rubella epidemic in Vietnam: characteristic of rubella virus genes from pregnant women and their fetuses/newborns with congenital rubella syndrome.2013

    • Author(s)
      Van Hung Pham, Thong Van Nguyen, Truc Thanh Thi Nguyen, Linh Duy Dang, Ngoc Hieu Hoang, Truong Van Nguyen, Kenji Abe
    • Journal Title

      Journal of Clinical Virology

      Volume: 57 Pages: 152-156

    • URL

      http://dx.doi.org/10.1016/j.jcv.2013.02.008

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Detection of hepatitis B virus DNA in paraffin-embedded intrahepatic and extrahepatic cholangiocarcinoma tissue in the northern Chinese population.2012

    • Author(s)
      Yiqi Wu, Tianzhen Wang, Shengqian Ye, Ran Zhao, Xiaohui Bai, Yingying Wu, Kenji Abe, Xiaoming Jin
    • Journal Title

      Human Pathology

      Volume: 43 Issue: 1 Pages: 56-61

    • DOI

      10.1016/j.humpath.2011.04.004

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete coding sequence and molecular analysis of hepatitis A virus from a chimpanzee with fulminant hepatitis.2012

    • Author(s)
      Apiradee Theamboonlers, Kenji Abe, Chittima Thongmee, Yong Poovorawan
    • Journal Title

      Journal of Medical Primatology

      Volume: 41 Issue: 1 Pages: 11-17

    • DOI

      10.1111/j.1600-0684.2011.00515.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HCV 6a prevalence in guangdong province had the origin from Vietnam and recent dissemination to other regions of China: Phylogeographic analyses.2012

    • Author(s)
      Yongshui Fu, Weibing Qin, Hong Cao, Ru Xu, Yi Tan, Teng Lu, Hongren Wang, Wangxia Tong, Xia Rong, Gang Li, Manqiong Yuan, Chunhua Li, Kenji Abe, Ling Lu
    • Journal Title

      PLoS One

      Volume: 7 Issue: 1 Pages: e28006-e28006

    • DOI

      10.1371/journal.pone.0028006

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Systematic review: Epidemiology of hepatitis C genotype 6 and its management.2011

    • Author(s)
      David T. Chao, Kenji Abe, Mindie H. Nguyen
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 34 Issue: 3 Pages: 286-296

    • DOI

      10.1111/j.1365-2036.2011.04714.x

    • Related Report
      2012 Final Research Report
  • [Journal Article] Very high prevalence of hepatitis C virus genotype 6 variants in Southern Vietnam: Large-scale survey based on sequence determination2011

    • Author(s)
      Van H. Pham, Huyen D.P. Nguyen, Phat T. Ho, Dien V. Banh, Hoa L.T. Pham, Phiet H. Pham, Ling Lu, Kenji Abe
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 64 Pages: 537-539

    • Related Report
      2012 Final Research Report
  • [Journal Article] Very high prevalence of hepatitis C virus genotype 6 variants in Southern Vietnam : Large-scale survey based on sequence determination2011

    • Author(s)
      Van H.Pham, 他7名
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 64 Pages: 537-539

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic progenitor cells in liver cancers from Asian children.2010

    • Author(s)
      Stephen C. Ward, Swan N. Thung, Kiat Hon Lim, Tung Thanh Tran, Thi Khang Bui Hong, Phuc Le Hoang, Ja June Jang, Young Nyun Park, Kenji Abe
    • Journal Title

      Liver International

      Volume: 30 Issue: 1 Pages: 102-111

    • DOI

      10.1111/j.1478-3231.2009.02126.x

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] Presence of hepatitis C virus RNA by nested polymerase chain reaction in plasma-derived hepatitis B vaccine non-responders.2010

    • Author(s)
      Moh Moh Htun, Khin Pyone Kyi, Khin May Oo, Myo Khin, Win Maw Tun, San San Oo, Khin Ohnmar Lwin, Kenji Abe
    • Journal Title

      Myanmar Health Sciences Research Journal

      Volume: 22 Pages: 101-104

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] Pre-S2 deletion mutants of hepatitis B virus could have an important role in hepatocarcinogenesis in Asian children.2009

    • Author(s)
      Kenji Abe, Swan N. Thung, Han-Chieh Wu, Tung Thanh Tran, Phuc Le Hoang, Khai Dinh Truong, Ayano Inui, Ja June Jang, Ih-Jen Su
    • Journal Title

      Cancer Science

      Volume: 100 Issue: 12 Pages: 2249-2254

    • DOI

      10.1111/j.1349-7006.2009.01309.x

    • NAID

      10027197722

    • Related Report
      2012 Final Research Report
  • [Journal Article] Review: Pathology of hepadna virus infection in humans and animals.2009

    • Author(s)
      Kenji Abe
    • Journal Title

      Thai Journal of Veterinary Medicine

      Volume: 39 Pages: 453-455

    • Related Report
      2012 Final Research Report
  • [Journal Article] Pre-S2 deletion mutants of hepatitis B virus could have an important role in hepatocarcinogenesis in Asian children2009

    • Author(s)
      Kenji Abe, et al.
    • Journal Title

      Cancer Science 100

      Pages: 2249-2254

    • NAID

      10027197722

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathology of hepadna virus infection in humans and animals2009

    • Author(s)
      Kenji Abe, et al.
    • Journal Title

      Thai Journal of Veterinary Medicine 39

      Pages: 453-455

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Occult HBV and HCV infection in non-B non-C hepatocellular carcinoma: A clinical and molecular pathologic study.2013

    • Author(s)
      Mabel Ko, Hongfa Zhu, Kenji Abe, Xuchen Zhang, Isabel Fiel, Stephen Ward, Swan N. Thung
    • Organizer
      102nd Annual Meeting of The United States and Canadian Academy of Pathology (USCAP)
    • Place of Presentation
      Baltimore, U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] Occult HBV and HCV infection in non-B non-C hepatocellular carcinoma: A clinical and molecular pathologic study.2013

    • Author(s)
      Mabel Ko, Hongfa Zhu, Kenji Abe, Xuchen Zhang, Isabel Fiel, Stephen Ward, Swan N. Thung
    • Organizer
      102nd Annual Meeting of The United States and Canadian Academy of Pathology (USCAP),
    • Place of Presentation
      アメリカ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小児期のHBV関連肝細胞癌の発生に関する検討2012

    • Author(s)
      乾あやの、角田知之、十河剛、小松陽樹、藤澤知雄、阿部賢治
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Hepatitis B virus associated hepatocarcinogenesis in Asian children.2012

    • Author(s)
      Ayano Inui, Tomoo Fuijisawa, Tomoyuki Tsunoda, Manari Kawamoto, Sonoko Ijichi, Tsuyoshi Sogo, Haruki Komatsu, Ih-Jen Su and Kenji Abe
    • Organizer
      4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition (WCPGHAN)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Final Research Report
  • [Presentation] Invited lecture: Animal models for human hepatitis B.2012

    • Author(s)
      Kenji Abe
    • Organizer
      7th National Conference of Vietnamese Association for Hepatology
    • Place of Presentation
      Danang, Vietnam
    • Related Report
      2012 Final Research Report
  • [Presentation] Hepatitis B virus associated hepatocarcinogenesis in Asian children.2012

    • Author(s)
      Ayano Inui, Tomoo Fuijisawa, Tomoyuki Tsunoda, Manari Kawamoto, Sonoko Ijichi, Tsuyoshi Sogo, Haruki Komatsu, Ih-Jen Su and Kenji Abe
    • Organizer
      4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition (WCPGHAN),
    • Place of Presentation
      台湾
    • Related Report
      2012 Annual Research Report
  • [Presentation] Invited lecture: Animal models for human hepatitis B.2012

    • Author(s)
      Kenji Abe
    • Organizer
      7th National Conference of Vietnamese Association for Hepatology.
    • Place of Presentation
      ベトナム
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Invited lecture: Hepatitis B and C in Asia.2011

    • Author(s)
      Kenji Abe
    • Organizer
      National Conference of Vietnamese Association for Hepatology
    • Place of Presentation
      Dalat, Vietnam
    • Related Report
      2012 Final Research Report
  • [Presentation] Hepatitis B and C in Asia2011

    • Author(s)
      Kenji Abe
    • Organizer
      National Conference of Vietnamese Association for Hepatology
    • Place of Presentation
      ベトナム・ダラット市(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Invited lecture: Hepatitis C in experimentally infected chimpanzees: comparison with hepatitis B.2010

    • Author(s)
      Kenji Abe
    • Organizer
      4th Ditan International Conference on Infectious Diseases
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Final Research Report
  • [Presentation] Invited lecture: Molecular-based epidemiology and pathology of hepatitis B virus infection2010

    • Author(s)
      Kenji Abe
    • Organizer
      The National Conference on Medical Molecular Biology and Biochemistry
    • Place of Presentation
      Hanoi, Vietnam
    • Related Report
      2012 Final Research Report
  • [Presentation] Invited lecture : Hepatitis C in experimentally infected chimpanzees : comparison with hepatitis B.2010

    • Author(s)
      Kenji Abe
    • Organizer
      4th Ditan International Conference on Infectious Diseases
    • Place of Presentation
      中国・北京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Invited lecture : Molecular-based epidemiology and pathology of hepatitis B virus infection.2010

    • Author(s)
      Kenji Abe
    • Organizer
      The National Conference on Medical Molecular Biology and Biochemistry
    • Place of Presentation
      ベトナム・ハノイ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stem cell origin of liver cancers in Asian children.2009

    • Author(s)
      Swan N. Thung, Tung Thanh Tran, Phuc Le Hoang, Ja June Jang, Young Nyun Park, Kenji Abe
    • Organizer
      United States and Canadian Academy of Pathology
    • Place of Presentation
      Boston, U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] Invited lecture: Pathogenesis of hepatitis B virus infection and its related hepatocellular carcinoma.2009

    • Author(s)
      Kenji Abe
    • Organizer
      The 7th Pathology Conference of Vietnam
    • Place of Presentation
      Ho Chi Minh City, Vietnam
    • Related Report
      2012 Final Research Report
  • [Presentation] Invited lecture: Pathology of hepadna virus infection in humans and animals.2009

    • Author(s)
      Kenji Abe
    • Organizer
      The 4th Asian Society of Veterinary Pathologists (ASVP) Conference
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Final Research Report
  • [Presentation] Hot spot mutation of hepatitis B virus pre-S2 gene related to hepatocellular carcinoma in Asian children.2009

    • Author(s)
      Kenji Abe, Swan N. Thung, Han-Chieh Wu, Tung Thanh Tran, Phuc Le Hoang, Ayano Inui, Ja June Jang, Ih-Jen Su
    • Organizer
      The Excellence in Pediatrics International Conference
    • Place of Presentation
      Firenze, Italy
    • Related Report
      2012 Final Research Report
  • [Presentation] Pathogenesis of hepatitis B virus infection and its related hepatocellular carcinoma2009

    • Author(s)
      Kenji Abe
    • Organizer
      The 7th Pathology Conference of Vietnam
    • Place of Presentation
      ベトナム・ホーチミン市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pathology of hepadna virus infection in humans and animals2009

    • Author(s)
      Kenji Abe
    • Organizer
      The 4th Asian Society of Veterinary Pathologist Conference
    • Place of Presentation
      タイ・バンコク
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hot spot mutation of hepatitis B virus pre-S2 gene related to hepatocellular carcinoma in Asian children2009

    • Author(s)
      Kenji Abe, et al.
    • Organizer
      The Excellence in Paediatrics International Conference
    • Place of Presentation
      イタリア・フィレンツェ
    • Related Report
      2009 Annual Research Report
  • [Book] Hepatitis B virus. Chapter 76 (In: Don Liu eds. Molecular detection of human viral pathogens)2010

    • Author(s)
      Kenji Abe
    • Publisher
      Taylor & Francis CRC Press
    • Related Report
      2012 Final Research Report
  • [Book] Hepatitis B virus.(Molecular detection of human viral pathogens.)(Don Liu eds.)2010

    • Author(s)
      Kenji Abe
    • Publisher
      Taylor & Francis CRC Press, Florida, U.S.A.
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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