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Exploration of regionality in laboratory test results and derivation of common reference intervals through international collaborative survey

Research Project

Project/Area Number 21406015
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Laboratory medicine
Research InstitutionYamaguchi University

Principal Investigator

ICHIHARA Kiyoshi  山口大学, 大学院・医学系研究科, 教授 (10144495)

Co-Investigator(Kenkyū-buntansha) NOJIMA Junzo  山口大学, 大学院・医学系研究科, 教授 (30448071)
SHIMIZU Yoshihisa  山口大学, 大学院・医学系研究科, 助教 (80403674)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords基準範囲 / 東南アジア / 標準化 / 多施設共同研究 / 地域差 / 臨床検査値変動要因 / パネル血清 / 海外学術調査 / 枝分かれ分散分析 / 地域差分析 / 臨床化学検査 / イムノアッセイ / クロスチェック / 生理的変動 / 国際連携 / 多変量解析 / IFCC
Research Abstract

An international multi-center study on reference values was conducted in 2009 with participation of 62 laboratories in South-east Asia. 3541 well-defined healthy individuals(Japan 2082 ; oversea 1459) were recruited. All sera were measured collectively for 72 commonly measured analytes in Japan. Regionality of test results was observed in 22 analytes, but it was not when data were limited to those from Japan. A variety of evidence on sources of variations was analyzed based on life style questionnaire. With successful outcome, an expanded study of a global scale was planned and launched with elaboration of common protocol in 2011.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 1 results) Presentation (17 results) Book (1 results)

  • [Journal Article] 基準範囲設定に関する国際動向2011

    • Author(s)
      市原清志
    • Journal Title

      生物試料分析

      Volume: 34 Pages: 211-217

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 臨床検査のstandardizationからharmonizationへ2010

    • Author(s)
      市原清志
    • Journal Title

      臨床化学

      Volume: 39 Pages: 386-387

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] An appraisal of statistical procedures used in derivation of reference intervals2010

    • Author(s)
      Ichihara K, Boyd J
    • Journal Title

      Clin Chem Lab Med

      Volume: 48 Pages: 1537-1551

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 共有基準範囲設定国際プロジェクト2009

    • Author(s)
      市原清志
    • Journal Title

      臨床化学

      Volume: 38 Pages: 416-423

    • NAID

      10026445933

    • Related Report
      2011 Final Research Report
  • [Journal Article] 標準化up-to-date:共有基準範囲設定国際プロジェクト2009

    • Author(s)
      市原清志
    • Journal Title

      臨床化学 38

      Pages: 416-423

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 共有基準範囲のニーズとその実現に向けて2009

    • Author(s)
      市原清志
    • Journal Title

      臨床化学 38

      Pages: 189-190

    • NAID

      10025633002

    • Related Report
      2009 Annual Research Report
  • [Presentation] The strategy of the IFCC global reference interval project reflecting lessons from the 2009 Asian multicenter study2011

    • Author(s)
      Ichihara K.
    • Organizer
      Symposium on" Is that normal?-Reference interval studies around the world", AACC Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2011-07-25
    • Related Report
      2011 Final Research Report
  • [Presentation] The strategy of the IFCC global reference interval project reflecting lessons from the 2009 Asian multicenter study. Symposium on "Is that normal?---Reference interval studies around the world"2011

    • Author(s)
      Ichihara, K
    • Organizer
      2011 Annual Meeting of Amer Assoc of Clin Chem
    • Place of Presentation
      Atlanta, USA(招待講演)
    • Year and Date
      2011-07-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Study design : strategy for collaboration in the definition of reference intervals2011

    • Author(s)
      Ichihara K.
    • Organizer
      Workshop on" Lessons from the Asian-Pacific multicenter reference interval study" during IFCC/ EFCC WorldMedLab 2011
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2011-05-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Study design : strategy for collaboration in the definition of reference intervals. Workshop on "Lessons from the Asian-Pacific multicenter reference interval study" during2011

    • Author(s)
      Ichihara, K
    • Organizer
      IFCC/EFCC WorldMedLab 2011
    • Place of Presentation
      Berlin, Germany(招待講演)
    • Year and Date
      2011-05-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 基準範囲設定にかかわる諸問題と解決策の模索共有基準範囲設定国際プロジェクトからの知見2010

    • Author(s)
      市原清志
    • Organizer
      第42回日本臨床検査自動化学会年次集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] The strategy and an overview of the results-regionality and age/ sex related changes in test results2010

    • Author(s)
      Ichihara K.
    • Organizer
      In Symposium :" The Asian Project for Joint Derivation of Reference Intervals and Exploration of Diagnostic Evidence for Laboratory Medicine" The 12th Asian-Pacific Congress of Clinical Biochemistry
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-10-06
    • Related Report
      2011 Final Research Report
  • [Presentation] The strategy and an overview of the results-regionality and age/sex related changes in test results2010

    • Author(s)
      Ichihara, K
    • Organizer
      The 12^<th> Asian-Pacific Congress of Clinical Biochemistry
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-10-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 共有基準範囲の設定と導入に必要な統計学の基礎知識2010

    • Author(s)
      市原清志
    • Organizer
      第50回日本臨床化学会年次集会
    • Place of Presentation
      甲府
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] AACC/NIST Harmonization Forum標準化未対応検査に関する国際協議と日本の対応2010

    • Author(s)
      市原清志
    • Organizer
      第50回日本臨床化学会年次集会
    • Place of Presentation
      甲府
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 国際研究プロジェクト「臨床検査値の地域差分析と共有基準範囲の設定」の成果について2010

    • Author(s)
      市原清志
    • Organizer
      日本内分泌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Invited lecture." Study of regionality in laboratory test results and collaborating derivation of reference intervals"2010

    • Author(s)
      Ichihara K.
    • Organizer
      Chinese National Congress of Laboratory Medicine 2010
    • Place of Presentation
      Harbin, China
    • Year and Date
      2010-01-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Study of regionality in laboratory test results and collaborative derivation of reference intervals (RI).2010

    • Author(s)
      Kiyoshi Ichihara
    • Organizer
      中国検査医学学会2010
    • Place of Presentation
      ハルビン、中国
    • Year and Date
      2010-01-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 国際プロジェクトによる基準範囲の共同設定:中間報告と今後の展望2009

    • Author(s)
      市原清志
    • Organizer
      第41回日本臨床検査自動化学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Key note lecture." Outline of the results from the third Asian project"2009

    • Author(s)
      Ichihara K.
    • Organizer
      Intl Symposium on Joint Determination of Reference Intervals and Data Analysis for Evidence-Based Laboratory Medicine
    • Place of Presentation
      Osaka, Hyatt Regency Osaka
    • Year and Date
      2009-09-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Plenary lecture :" An Asian study on regionality of test results in 97 analytes and collaborative derivation of common reference intervals"2009

    • Author(s)
      Ichihara K.
    • Organizer
      The 14th Annual Conference of APIII(Advancing Practice, Introduction & Innovation thorough Informatics)
    • Place of Presentation
      Pittsburgh, USA
    • Year and Date
      2009-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 基準範囲設定国際プロジェクト:設定値のユニバーサルな利用をめざして2009

    • Author(s)
      市原清志
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 共有基準範囲の設定と運用に関するガイドラインの作成2009

    • Author(s)
      市原清志
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Book] エビデンスに基づく検査診断実践マニュアル2011

    • Author(s)
      市原清志、河口勝憲
    • Publisher
      日本教育研究センター
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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