| Project/Area Number |
21406016
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
NASU Tamie 名古屋大学, 大学院・医学系研究科, 教授 (10020794)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIJIMA Michihiro 名古屋市立大学, 大学院・医学研究科, 教授 (80281070)
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| Co-Investigator(Renkei-kenkyūsha) |
YANAGIBA Yukie 独立行政法人労働衛生研究所, 研究員 (90467283)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | トリクロロエチレン / Hypersensitivity / HLA-B* 1301 / HHV6 / TNFα / IL10 / トリクロロ酢酸 / 疫学研究 / HLA-B^*1301多型 / 患者 / 対照者 / 生物学的許容値 / 健康労働者 / HLA-B*1301 / 遺伝子多型 / 全身性皮膚-肝障害 / 工場労働者 / HLA多型 / サイトカイン / トリクロロエタノール |
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| Research Abstract |
We investigated trichloroethylene exposure levels, HLA-B genotypes, human herpes virus 6(HHV6) reactivation and cytokine levels(TNFαand IL10) in 82 patients with hypersensitivity and 137 healthy controls who worked factory using trichloroethylene. Frequencies of HLA-B* 1301 genotype were 55 patients(67%) in the patients, while only 8 persons(6%) in the control workers. Of 38 patients, 27 patients(71%) had HLA-B : 1301 genotype, and urinary TCA levels of 22 patients(81. 5%) exceeded biological exposure index of trichloroethylene. However, all control workers with HLA-B : 1301 genotype estimated to work under biological exposure index of trichloroethylene. Frequencies of patients with HHV6 reactivation(85%), elevations of plasma TNFα(57%) and IL10(85. 3%) were significantly higher in the patients group than control workers(14. 5, 14. 5 and 3. 6%, respectively).
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