Epidemiological study on environmental and genetic factor of trichlroetylene-induced hypersensitivity
| Project/Area Number |
21406016
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 海外学術 |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
NASU Tamie 名古屋大学, 大学院・医学系研究科, 教授 (10020794)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAMIJIMA Michihiro 名古屋市立大学, 大学院・医学研究科, 教授 (80281070)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YANAGIBA Yukie 独立行政法人労働衛生研究所, 研究員 (90467283)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
|---|
| Keywords | トリクロロエチレン / Hypersensitivity / HLA-B* 1301 / HHV6 / TNFα / IL10 / トリクロロ酢酸 / 疫学研究 / HLA-B^*1301多型 / 患者 / 対照者 / 生物学的許容値 / 健康労働者 / HLA-B*1301 / 遺伝子多型 / 全身性皮膚-肝障害 / 工場労働者 / HLA多型 / サイトカイン / トリクロロエタノール |
|---|
| Research Abstract |
We investigated trichloroethylene exposure levels, HLA-B genotypes, human herpes virus 6(HHV6) reactivation and cytokine levels(TNFαand IL10) in 82 patients with hypersensitivity and 137 healthy controls who worked factory using trichloroethylene. Frequencies of HLA-B* 1301 genotype were 55 patients(67%) in the patients, while only 8 persons(6%) in the control workers. Of 38 patients, 27 patients(71%) had HLA-B : 1301 genotype, and urinary TCA levels of 22 patients(81. 5%) exceeded biological exposure index of trichloroethylene. However, all control workers with HLA-B : 1301 genotype estimated to work under biological exposure index of trichloroethylene. Frequencies of patients with HHV6 reactivation(85%), elevations of plasma TNFα(57%) and IL10(85. 3%) were significantly higher in the patients group than control workers(14. 5, 14. 5 and 3. 6%, respectively).
|
Report
(4 results)
Research Products
(15 results)
-
[Journal Article] Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice2010
Author(s)
Ramdhan DH, Kamijima M, Wang D, Ito Y, Naito H, Yanagiba Y, Hayashi Y, TanakaN, Aoyama T, Gonzalez FJ, Nakajima T.
-
Journal Title
Environ Health Perspect
Volume: 118
Pages: 1557-1563
Related Report
Peer Reviewed
-
[Journal Article] Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARalpha-Humanized Mice.2010
Author(s)
Ramdhan DH, Kamijima M, Wang D, Ito Y, Naito H, Yanagiba Y, Hayashi Y, Tanaka N, Aoyama T, Gonzalez FJ, Nakajima T.
-
Journal Title
Environmental Health Perspective
Volume: 118(11)
Pages: 1557-1563
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Presentation]2010
Author(s)
那須民江
Organizer
第83回 日本産業衛生学会
Place of Presentation
福井国際交流会館
Year and Date
2010-05-26
Related Report
-
-
-
-
-
-
