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Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans

Research Project

Project/Area Number 21406017
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionNagoya University

Principal Investigator

ICHIHARA Gaku  名古屋大学, 大学院・医学系研究科, 准教授 (90252238)

Co-Investigator(Kenkyū-buntansha) WAKAI Kenji  名古屋大学, 大学院・医学系研究科, 准教授 (50270989)
市原 佐保子  見え大学, 地域イノベーション学研究科, 准教授 (20378326)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsブロモプロパン / 神経毒性 / 量反応関係 / 1-ブロモプロパン / 中枢神経毒性 / 振動覚 / 労働衛生調査 / MRI / 多発性硬化症 / 量反応性 / 中毒症例 / 疫学調査 / 血液毒性 / 中枢神経 / 分子疫学
Research Abstract

The analysis of workers exposed to 1-bromopropane and non-exposed workers was conducted using ANOVA followed by Dunnett's multiple comparison and regression analysis. The result showed dose-dependent increase in distal latency, threshold for vibration sense, LDH, TSH, FSH and dose-dependent decrease in sensory nerve conduction velocity, red blood cell, hematocrit. The cases intoxicated with 1-bromopropane showed degeneration of peripheral nerve histopathologically and the abnormality in the central nervous system.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (160 results)

All 2012 2011 2010 2009 Other

All Journal Article (29 results) (of which Peer Reviewed: 27 results) Presentation (121 results) Book (9 results) Remarks (1 results)

  • [Journal Article] Evidence from animal experiments and human studies2012

    • Author(s)
      Ichihara G, et al
    • Journal Title

      J Adv Res

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis2011

    • Author(s)
      Nagai H., et al
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Pages: 1330-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane2011

    • Author(s)
      Huang Z., et al
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 257 Pages: 93-101

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent neurologic abnormalities in workers exposed to1-bromopropane : authors' response2011

    • Author(s)
      Ichihara G, et al
    • Journal Title

      J Occup Environ Med

      Volume: 53 Pages: 1095-1098

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pleural plaques profile on chest radiograph and CT scan of asbestos-exposed Japanese construction workers2011

    • Author(s)
      Elshazley M, et al
    • Journal Title

      Ind Health

      Volume: 49 Pages: 626-633

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to1-bromopropane causes degeneration of noradrenergic axons in the rat brain2011

    • Author(s)
      Mohideen SS, et al
    • Journal Title

      Toxicology

      Volume: 285 Pages: 67-71

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain2011

    • Author(s)
      Mohideen SS, et al
    • Journal Title

      Toxicology

      Volume: 285 Pages: 67-71

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane : authors' response2011

    • Author(s)
      Ichihara G, et al
    • Journal Title

      J Occup Environ Med

      Volume: 53 Pages: 1095-1098

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis2011

    • Author(s)
      Nagai H., et al.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane2010

    • Author(s)
      Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: 52 Pages: 769-777

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of the Transcription Factor Nrf2 Promotes Ischemia-Induced Neovascularization by Enhancing the Inflammatory Response2010

    • Author(s)
      Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 30 Pages: 1553-1561

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased susceptibility of Nrf2null mice to 1-bromopropane-inducedhepatotoxicity2010

    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Sheik Mohideen S, Kitoh J, Ichihara G
    • Journal Title

      Toxicological Sciences

      Volume: 115 Pages: 596-606

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromo propane.2010

    • Author(s)
      Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G.
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: 52 Pages: 769-777

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of the Transcription Factor Nrf2 Promotes Ischemia-Induced Neovascularization by Enhancing the Inflammatory Response.2010

    • Author(s)
      Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 30 Pages: 1553-1561

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity.2010

    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Sheik Mohideen S, Kitoh J, Ichihara G.
    • Journal Title

      Toxicol Sci.

      Volume: 115 Pages: 596-606

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased susceptibility of Nrf2 null mice to 1-bromopropane-induced hepatotoxicity2010

    • Author(s)
      Liu F, et al.
    • Journal Title

      Toxicological Sciences (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study on susceptibility to 1-bromopropane in three mice strains2009

    • Author(s)
      Liu F, Ichihara S, Mohideen SS, Sai U, KitohJ, Ichihara G
    • Journal Title

      Toxicological Sciences

      Volume: 112 Pages: 100-10

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in neuro transmitter receptor expression levels in rat brain after 4-week exposure to1-bromopropane2009

    • Author(s)
      Mohideen SS, Ichihara S, Banu S, Liu F, Kitoh J, Ichihara G
    • Journal Title

      Neurotoxicology

      Volume: 30 Pages: 1078-83

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ischemia-induced angiogenesis by benzo[a] pyrene in a manner dependent on the aryl hydrocarbon receptor2009

    • Author(s)
      Ichihara S, Yamada Y, Gonzalez FJ, Nakajima T, Murohara T, Ichihara G
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 381 Pages: 44-49

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ye DQ. Melatonin pretreatment attenuates 2-bromopropane-induced testicular to xicity in rats2009

    • Author(s)
      Huang F, Ning H, Xin QQ, Huang Y, Wang H, Zhang ZH, Xu DX, Ichihara G
    • Journal Title

      Toxicol

      Volume: 256 Pages: 75-82

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticles :-one word : a multiplicity of different hazards2009

    • Author(s)
      Donaldson K, Oberdorster G, Ichihara G, Maynard A, Stone V, Borm P, Aitken R.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 3 Pages: 263-264

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 有機溶剤中毒と尿検査2009

    • Author(s)
      市原学
    • Journal Title

      総合臨床

      Volume: 58 Pages: 1269-1271

    • Related Report
      2011 Final Research Report
  • [Journal Article] Comparative study on susceptibility to 1-bromopropane in three mice strains2009

    • Author(s)
      Liu F, et al.
    • Journal Title

      Toxicological Sciences 112

      Pages: 100-110

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in neurotransmitter receptor expression levels in rat brain after 4-week exposure to 1-bromopropane2009

    • Author(s)
      Mohideen SS, et al.
    • Journal Title

      Neurotoxicology 30

      Pages: 1078-1083

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor2009

    • Author(s)
      Ichihara S, et al.
    • Journal Title

      Biochem Biophys Res Commun 381

      Pages: 44-49

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin pretreatment attenuates 2-bromopropane-induced testicular toxicity in rats. Toxicology2009

    • Author(s)
      Ichihara S, et al.
    • Journal Title

      Biochem Biophys Res Commun 256

      Pages: 75-82

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticles-one word : A multiplicity of different hazards. Nanotoxicology2009

    • Author(s)
      Aitken R, et al.
    • Journal Title

      Biochem Biophys Res Commun 3

      Pages: 263-264

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 有機溶剤中毒と尿検査2009

    • Author(s)
      市原学
    • Journal Title

      総合臨床 58

      Pages: 1269-1271

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence from animal experiments and human studies

    • Author(s)
      Ichihara G, et al
    • Journal Title

      J Adv Res

      Volume: (inpress) Pages: 2012-2012

    • Related Report
      2011 Final Research Report
  • [Presentation] ラット脳内モノアミンレベルと海馬神経栄養因子の発現への1-ブロモプロパン曝露の影響2012

    • Author(s)
      張霊逸, ほか
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 1-ブロモプロパン曝露のラット小脳におけるグリア2012

    • Author(s)
      シェイクモヒディーンサハブディーン, ほか
    • Organizer
      ミエリンに対する影響第82回日本衛生学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 二酸化チタンナノ粒子による細胞毒性作用の解析2012

    • Author(s)
      及川(多田)佐枝子, ほか
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] メタボリック症候群の標的分子マーカーの検索2012

    • Author(s)
      常杰, ほか
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomic Identification of Carbonyl Ted Proteins in F344 Rat Hippocampus after 1-BromopropaneExposure2012

    • Author(s)
      Huang Z, et al
    • Organizer
      The 51th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      米国サンフランシスコ
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomic Identification of Carbonyl Ted Proteins in F344 Rat Hippocampus after 1-BromopropaneExposure2012

    • Author(s)
      黄振烈, ほか
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット脳内モノアミンレベルと海馬神経栄養因子の発現における1-ブロモプロパン曝露の影響2012

    • Author(s)
      張霊逸, ほか
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷
    • Related Report
      2011 Final Research Report
  • [Presentation] Exposure to 1-bromopropane induces activation of astrocyte and degeneration of neuronal cells in rat cerebellum2012

    • Author(s)
      シェイクモヒディーンサハブディーン, ほか
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷
    • Related Report
      2011 Final Research Report
  • [Presentation] 高血糖状態における血小板リン酸化タンパク質の同定2012

    • Author(s)
      紅林真理恵, ほか
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomic Identification of Carbonylated Proteins in F344 Rat Hippocampus after 1-Bromopropane Exposure2012

    • Author(s)
      Huang Z, et al
    • Organizer
      The 51th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      米国サンフランシスコ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Proteomic Identification of Carbonylated Proteins in F344 Rat Hippocampus after 1-Bromopropane Exposure2012

    • Author(s)
      黄振烈, ほか
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷、倉敷市民会館
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット脳内モノアミンレベルと海馬神経栄養因子の発現における1-ブロモプロパン曝露の影響2012

    • Author(s)
      張霊逸, ほか
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷、倉敷市民会館
    • Related Report
      2011 Annual Research Report
  • [Presentation] Exposure to 1-bromopropane induces activation of astrocyte and degeneration of neuronal cells in rat cerebellum2012

    • Author(s)
      シェイクモヒディーン サハブディーン, ほか
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷、倉敷市民会館
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高血糖状態における血小板リン酸化タンパク質の同定2012

    • Author(s)
      紅林真理恵, ほか
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷、倉敷市民会館
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット脳内モノアミンレベルと海馬神経栄養因子の発現への1-ブロモプロパン曝露の影響2012

    • Author(s)
      張霊逸, ほか
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都、京都大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露のラット小脳におけるグリア、ミエリンに対する影響2012

    • Author(s)
      シェイクモヒディーン,サハブディーン, ほか
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都、京都大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] 二酸化チタンナノ粒子による細胞毒性作用の解析2012

    • Author(s)
      及川(多田)佐枝子, ほか
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都、京都大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] メタボリック症候群の標的分子マーカーの検索2012

    • Author(s)
      常杰, ほか
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都、京都大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] Presearches on manufacturednanomaterials in Japan2011

    • Author(s)
      Ichihara G EHS
    • Organizer
      The Seventh International Nanotechnology Conference oncommunication and collaboration(INC7)
    • Place of Presentation
      米国オーバニー
    • Year and Date
      2011-05-18
    • Related Report
      2011 Final Research Report
  • [Presentation] EHS researches on manufactured nanomaterials in Japan2011

    • Author(s)
      Gaku Ichihara
    • Organizer
      INC7
    • Place of Presentation
      米国オーバニー(招待講演)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hyperphosphatemia and hypozincemia aggravated hypertension and cardiac dysfunction in SHR/NDmcr-cp, amodel of metabolic syndrome2011

    • Author(s)
      Suzuki Y., et al
    • Organizer
      The 84th Scientific Sessions of American Heart Association
    • Place of Presentation
      米国、オーランド
    • Related Report
      2011 Final Research Report
  • [Presentation] Oxidative modification of the proteins related to ATP synthesis leads to the left ventricular dysfunction incardiomyopathy2011

    • Author(s)
      Ichihara S., et al
    • Organizer
      The 84th Scientific Sessions of American Heart Association
    • Place of Presentation
      米国、オーランド
    • Related Report
      2011 Final Research Report
  • [Presentation] Occupational health Surveyon workers handling titanium dioxide2011

    • Author(s)
      Ichihara S., et al
    • Organizer
      The 48th Congress of the European Societies of Toxicology
    • Place of Presentation
      フランス、パリ
    • Related Report
      2011 Final Research Report
  • [Presentation] Central nervous system toxicity of 1-bromopropane : an oxidative stress hypothesis2011

    • Author(s)
      Subramanian K, et al
    • Organizer
      The 48th Congress of the European Societies of Toxicology
    • Place of Presentation
      フランス、パリ
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Occupational health Surveyon workers handling titanium dioxide2011

    • Author(s)
      Ichihara S., et al.
    • Organizer
      The 5th International Symposium onNanotechnology, Occupational and Environmental Health
    • Place of Presentation
      米国ボストン
    • Related Report
      2011 Final Research Report
  • [Presentation] Neurotoxicity of 1-bromopropane, an alternative toozone-depleting solvents2011

    • Author(s)
      Ichihara G, et al
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国西安
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of 1-bromopropaneexposure on monoamine levels in brain andhippocampal brain-derived neurotrophicfactor expression in rats2011

    • Author(s)
      Lingyi Z, et al
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国西安
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomic analysis of hippocampal protein in f344 rats exposed to1-bromopropane2011

    • Author(s)
      Huang Z, et al
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国西安
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of 1-bromopropane exposure on myelinationand glia in rat brain2011

    • Author(s)
      Mohideen SS, et al.
    • Organizer
      Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methodsand Effects in Occupational and Environmental Health
    • Place of Presentation
      中国西安
    • Related Report
      2011 Final Research Report
  • [Presentation] Central nerve system toxicity of 1-bromopropane : an oxidativestress hypothesis2011

    • Author(s)
      Subramanian K, et al
    • Organizer
      Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methodsand Effects in Occupational and Environmental Health
    • Place of Presentation
      中国西安
    • Related Report
      2011 Final Research Report
  • [Presentation] 1-ブロモプロパンに曝露されたラットにおける脳海馬蛋白のプロテオミクス解析2011

    • Author(s)
      黄振烈, ほか
    • Organizer
      第84回日本産業衛生学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 1-ブロモプロパン曝露によるラット脳のミエリン化2011

    • Author(s)
      シェイクモヒディーンザハブデーン, ほか
    • Organizer
      アストロサイト活性化への影響第84回日本産業衛生学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 1-ブロモプロパンに曝露されたラットにおける脳海馬蛋白のプロテオミクス解析2011

    • Author(s)
      黄振烈、市原佐保子、及川伸二、常傑、張霊逸、スブラマニアン・カビアラサン、シェイクモヒディーン・サハブディーン、市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露によるラット脳のミエリン化、アストロサイト活性化への影響2011

    • Author(s)
      シェイクモヒディーン・サハブディーン、市原佐保子、黄振烈、張霊逸、スブラマニアン・カビアラサン、市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] オーストラリア鉱山における1-ブロモプロパン中毒事例2011

    • Author(s)
      市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      日昭和大学旗の台キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] 市原佐保子マイクロアレイ・プロテオーム解析によるメタボリック症候群の標的分子マーカーの探索2011

    • Author(s)
      常傑、及川伸二、安藤知紗、葛谷憲太郎、市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] 市原学ナノ酸化チタンの心肺機能への影響に関する調査研究2011

    • Author(s)
      市原佐保子、小林隆弘、李衛華、尾村誠一、平工雄介、丁訓誠
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] チェルノブイリ被災地域における罹患率調査(第1報)2011

    • Author(s)
      木村真三、七澤潔、竹内高明、三浦善憲、市原佐保子、市原学、サフー・サラタ、遠藤暁、大瀧慈、藤田博美
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 分散化多層カーボンナノチューブのラット脳への影響2011

    • Author(s)
      市原学、田中昭代、平田美由紀、市原佐保子、王強毅、伊東秀記
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Occupational health surveyon workers and nanoparticle number in factory handling nano-titanium dioxide2011

    • Author(s)
      Ichihara S, et al
    • Organizer
      50th Anniversary Annual Meeting and Tox Expo
    • Place of Presentation
      Washington, D. C., USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Genomics and proteomics analysis identified the proteins associated with adipocyte lipolysis as a key regulator for the pathogenesis or progression of metabolic syndrome2011

    • Author(s)
      Chang J, et al
    • Organizer
      50th Anniversary Annual Meeting and Tox Expo
    • Place of Presentation
      Washington, D. C., USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Exposure to 1-bromoproane degenerates noradrenergic axons in the ratbrain2011

    • Author(s)
      Ichihara G., et al
    • Organizer
      50th Anniversary Annual Meeting and Tox Expo
    • Place of Presentation
      Washington, D. C., USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of 1-bromopropane exposure on myelination and astroglia in rat brain2011

    • Author(s)
      Mohideen SS, et al
    • Organizer
      50th Anniversary Annual Meeting and Tox Expo
    • Place of Presentation
      Washington, D. C., USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Hyperphophatemia and hypozincemia affect peripheral nervous system in SHR/NDMCR-CP, a model of metabolic syndrome. Society of Toxicology2011

    • Author(s)
      Suzuki Y, et al
    • Organizer
      50th Anniversary Annual Meeting and Tox Expo
    • Place of Presentation
      Washington, D. C., USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Occupational health survey on factory handling Titanium2011

    • Author(s)
      Ichihara G, et al
    • Organizer
      ナノ・バイオメディシンシンポジウム(第4回ナノ・バイオメディカル学会大会)
    • Place of Presentation
      名古屋大学野依記念学術交流館
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Effects of 1-bromopropane exposure on myelination and astroglia activation in rat brain2011

    • Author(s)
      Mohideen SS., et al.
    • Organizer
      第10回分子予防環境医学研究大会
    • Place of Presentation
      京都府立医科大学
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Neurotoxicity of 1-bromopropane, an alternative to ozone-depleting solvents2011

    • Author(s)
      Gaku Ichihara, et al
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国西安
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of 1-bromopropane exposure on monoamine levels in brain and hippocampal brain-derived neurotrophic factor expression in rats2011

    • Author(s)
      Lingyi Z, et al
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国西安
    • Related Report
      2011 Annual Research Report
  • [Presentation] Proteomic analysis of hippocampal protein in f344 rats exposed to 1 -bromopropane2011

    • Author(s)
      Huang Z, et al
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国西安
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of 1-bromopropane exposure on myelination and glia in rat brain2011

    • Author(s)
      Mohideen SS, et al
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国西安
    • Related Report
      2011 Annual Research Report
  • [Presentation] Central nerve system toxicity of 1-bromopropane : an oxidative stress hypothesis2011

    • Author(s)
      Subramanian K, et al
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国西安
    • Related Report
      2011 Annual Research Report
  • [Presentation] Occupational health Survey on workers handling titanium dioxide2011

    • Author(s)
      Ichihara S., et al
    • Organizer
      The 5th International Symposium on Nanotechnology, Occupational and Environmental Health
    • Place of Presentation
      米国ボストン
    • Related Report
      2011 Annual Research Report
  • [Presentation] Occupational health Survey on workers handling titanium dioxide2011

    • Author(s)
      Ichihara S., et al
    • Organizer
      The 48th Congress of the European Societies of Toxicology
    • Place of Presentation
      フランス、パリ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hyperphosphatemia and hypozincemia aggravated hypertension and cardiac dysfunction in SHR/NDmcr-cp, a model of metabolic syndrome2011

    • Author(s)
      Suzuki Y., et al
    • Organizer
      The 84th Scientific Sessions of American Heart Association
    • Place of Presentation
      米国、オーランド
    • Related Report
      2011 Annual Research Report
  • [Presentation] Oxidative modification of the proteins related to ATP synthesis leads to the left ventricular dysfunction in cardiomyopathy2011

    • Author(s)
      Ichihara S., et al
    • Organizer
      The 84th Scientific Sessions of American Heart Association
    • Place of Presentation
      米国、オーランド
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト研究と動物実験による産業化学物質の毒性解明2011

    • Author(s)
      市原学, ほか
    • Organizer
      第84回日本産業衛生学会イブニングシンポジウム
    • Place of Presentation
      東京、ニューピアホール、ホテルアジュール竹芝、東京都立産業貿易センター浜松町館(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1-ブロモプロパンに曝露されたラットにおける脳海馬蛋白のプロテオミクス解析2011

    • Author(s)
      黄振烈, ほか
    • Organizer
      第84回日本産業衛生学会
    • Place of Presentation
      東京、ニューピアホール、ホテルアジュール竹芝、東京都立産業貿易センター浜松町館
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露によるラット脳のミエリン化、アストロサイト活性化への影響2011

    • Author(s)
      シェイク モヒディーン ザハブデーン, ほか
    • Organizer
      第84回日本産業衛生学会
    • Place of Presentation
      東京、ニューピアホール、ホテルアジュール竹芝、東京都立産業貿易センター浜松町館
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1-プロモプロパン曝露によるラット脳のミエリン化、アストロサイト活性化への影響2011

    • Author(s)
      シェイクモヒディーン・サハブディーン、市原佐保子、黄振烈、張霊逸、スブラマニアン・カビアラサン、市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] オーストラリア鉱山における1-ブロモプロパン中毒事例2011

    • Author(s)
      市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロアレイ・プロテオーム解析によるメタボリック症候群の標的分子マーカーの探索2011

    • Author(s)
      常傑、及川伸二、安藤知紗、葛谷憲太郎、市原学、市原佐保子
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] ナノ酸化チタンの心肺機能への影響に関する調査研究2011

    • Author(s)
      市原佐保子、小林隆弘、李衛華、尾村誠一、平工雄介、丁訓誠、市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] THE OCCUPATIONAL HEALTH SURVEY ON WORKERS AND NANOPARTICLE NUMBER IN THE FACTORY HANDLING NANO-TITANIUM DIOXIDE.2011

    • Author(s)
      S.Ichihara, W.Li, T.Kobayashi, S.Omura, Y.Hiraku, X.Ding, G. Ichihara.
    • Organizer
      50th Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] GENOMICS AND PROTEOMICS ANALYSIS IDENTIFIED THE PROTEINS ASSOCIATED WITH ADIPOCYTE LIPOLYSIS AS A KEY REGULATOR FOR THE PATHOGENESIS OR PROGRESSION OF METABOLIC SYNDROME.2011

    • Author(s)
      J.Chang, S.Oikawa, C.Ando, K.Kuzuya, G.Ichihara, S.Ichihara.
    • Organizer
      50th Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] EXPOSURE TO 1-BROMOPROPANE DEGENERATES NORADRENERGIC AXONS IN THE RAT BRAIN.2011

    • Author(s)
      G.Ichihara, S.Sheik Mohideen, S.Ichihara, S.Nakamura.
    • Organizer
      50th Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] EFFECTS OF 1-BROMOPROPANE EXPOSURE ON MYELINATION AND ASTROGLIA IN RAT BRAIN.2011

    • Author(s)
      S.SheikMohideen, S.Ichihara, Z.Huang, L.Zhang, K.Subramanian, J.Kitoh, G.Ichihara.
    • Organizer
      50th Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] HYPERPHOSPHATEMIA AND HYPOZINCEMIA AFFECT PERIPHERAL NERVOUS SYSTEM IN SHR/NDMCR-CP, A MODEL OF METABOLIC SYNDROME.2011

    • Author(s)
      Y.Suzuki, S.Ichihara, A.Kato, T.Yamaguchi, Y.Yamada, G.Ichihara.
    • Organizer
      50th Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Proteomic analysis of hippocampal protein in rats exposed 1-bromopropane2011

    • Author(s)
      Zhenlie Huang, Sahoko Ichihara, Shinji Oikawa, Jie Chang, Lingyi Zhang, Kaviarasan
    • Organizer
      第10回分子予防環境医学研究大会
    • Place of Presentation
      京都府立医科大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of oxidative stress in toxicity of 1-bromopropane2010

    • Author(s)
      Ichihara G, et al
    • Organizer
      The 6th International Forum on" Oxidative Stressand Aging"
    • Place of Presentation
      名古屋大学野依記念学術交流館
    • Year and Date
      2010-09-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of oxidative stress in toxicity of 1-bromopropane, an alternative to ozone-depleting solvents2010

    • Author(s)
      Gaku Ichihara, Fang Liu, Junzoh Kitoh, Sahoko Ichihara, Yasuhiro Takeuchi
    • Organizer
      The 6th International Forum on "Oxidative Stress and Aging"
    • Place of Presentation
      名古屋大学野依記念学術交流館
    • Year and Date
      2010-09-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane2010

    • Author(s)
      Ichihara G, et al
    • Organizer
      XII International Congress of Toxicology
    • Place of Presentation
      BarcelonaSpain
    • Year and Date
      2010-07-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Dose-dependent neurologic abnormalities in workers exposed to 1-bromo propane2010

    • Author(s)
      G.Ichihara, W.Li, E..Shibata, Z.Zhou, S.Ichihara, H.Wang, Q.Wang, J.Li, L..Zhang, Y.Takeuchi, X.Ding
    • Organizer
      XII International Congress of Toxicology
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酒井潔建設作業者の職種と胸膜肥厚斑発生部位に関する検討2010

    • Author(s)
      柴田英治、Mo' men Hafez、市原学、市原佐保子、上島通浩
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(フェニックス・プラザ)
    • Year and Date
      2010-05-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 建設作業者の職種と胸膜肥厚斑発生部位に関する検討2010

    • Author(s)
      柴田英治、Momen Hafbz、市原学、市原佐保子、上島通浩、酒井潔
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(フェニックス・プラザ)
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトにおける1-ブロモプロパンの量依存的な神経、血液、生化学指標への影響-再解析による新しい知見2010

    • Author(s)
      張霊逸、李衛華、柴田英治、市原佐保子、王強毅、李潔斐、若井健志、竹内康浩、丁訓誠、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館
    • Year and Date
      2010-05-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 1-ブロモプロパン曝露された労働者の脳核磁気共鳴画像と中枢神経障害2010

    • Author(s)
      近藤喜代太、渡辺宏久、伊藤高行、祖父江元、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館)
    • Year and Date
      2010-05-26
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 転写因子nrf2による生体防御反応と酸化ストレスの1-ブロモプロパン毒性における役割2010

    • Author(s)
      劉芳、市原佐保子、シェイクモヒディーンサハブディーン、伊東健、山本雅之、ウィリアムエムヴァレンタイン、鬼頭純三、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館
    • Year and Date
      2010-05-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 那須民江肺がん患者における職業的石綿曝露と肺内石綿濃度2010

    • Author(s)
      酒井潔、久永直見、柴田英治、上島通浩、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館)
    • Year and Date
      2010-05-26
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒトにおける1-ブロモプロパンの量依存的な神経、血液、生化学指標への影響-再解析による新しい知見-2010

    • Author(s)
      張霊逸、李衛華、柴田英治、市原佐保子、王強毅、李潔斐、若井健志、竹内康浩、丁訓誠、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館)
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 転写因子nrf2による生体防御反応と酸化ストレスの1-ブロモプロパン毒性における役割2010

    • Author(s)
      劉芳、市原佐保子、シェイクモヒディーンサハブディーン、伊東健、山本雅之、ウィリアムエムヴァレンタイン、鬼頭純三、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館)
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺がん患者における職業的石綿曝露と肺内石綿濃度2010

    • Author(s)
      酒井潔、久永直見、柴田英治、上島通浩、市原学、那須民江
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館)
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ストレス応答性転写因子Nrf2の心肥大における役割の解明2010

    • Author(s)
      市原佐保子、山田芳司、劉芳、伊東健、山本雅之、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター
    • Year and Date
      2010-05-10
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒトにおける1-ブロモプロパンの量依存的な健康影響-再解析による新しい知見2010

    • Author(s)
      張霊逸、李衛華、柴田英治、市原佐保子、王強毅、李潔斐、若井健志、竹内康浩丁訓誠、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2010-05-10
    • Related Report
      2011 Final Research Report
  • [Presentation] ノックアウトマウスは1-ブロモプロパン曝露に対し感受性が高い2010

    • Author(s)
      劉芳、市原佐保子、Sahabudeen Sheik Mohideen、伊東健、山本雅之、William M. Valentine、鬼頭純三、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター
    • Year and Date
      2010-05-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 1-ブロモプロパン曝露によるヒト中枢神経病変の核磁気共鳴画像(MRI)解析2010

    • Author(s)
      近藤喜代太、渡辺宏久、伊藤高行、祖父江元、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター
    • Year and Date
      2010-05-10
    • Related Report
      2011 Final Research Report
  • [Presentation] ストレス応答性転写因子Nrf2の心肥大における役割の解明2010

    • Author(s)
      市原佐保子、山田芳司、劉芳、伊東健、山本雅之、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトにおける1-ブロモプロパンの量依存的な健康影響-再解析による新しい知見2010

    • Author(s)
      張霊逸、李衛華、柴田英治、市原佐保子、王強毅、李潔斐、若井健志、竹内康浩、丁訓誠、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] nrf2ノックアウトマウスは1-ブロモプロパン曝露に対し感受性が高い2010

    • Author(s)
      劉芳、市原佐保子、Sahabudeen Sheik Mohideen、伊東健、山本雅之、William M.valentine、鬼頭純三、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露によるヒト中枢神経病変の核磁気共鳴画像(MRI)解析2010

    • Author(s)
      近藤喜代太、渡辺宏久、伊藤高行、祖父江元、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nrf2 null mice are more susceptible to 1-bromopropane-induced hepatotoxicity2010

    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Kitoh J, Ichihara G
    • Organizer
      第9回分子予防環境医学研究会
    • Place of Presentation
      東京大学大学院医学系研究科1号館1階講堂
    • Year and Date
      2010-01-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Nrf2 null mice are more susceptible to 1-bromopropane-induced hepatotoxicity2010

    • Author(s)
      劉芳, ら
    • Organizer
      第9回 分子予防環境医学研究会
    • Place of Presentation
      東京大学大学院医学系研究科1号館1階講堂
    • Year and Date
      2010-01-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] ストレス応答型転写因子Nrf2の血管新生における役割の解明2010

    • Author(s)
      市原佐保子,劉芳,山田芳司,室原豊明,伊東健,山本雅之,市原学
    • Organizer
      第9回分子予防環境医学研究会
    • Place of Presentation
      東京大学大学院医学系研究科1号館1階講堂
    • Year and Date
      2010-01-22
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒト研究と動物実験による産業化学物質の毒性解明2010

    • Author(s)
      市原学, ほか
    • Organizer
      第84回日本産業衛生学会イブニングシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomic analysis of hippocampal protein in rats exposed 1-bromopropane2010

    • Author(s)
      Huang Z, et al
    • Organizer
      第10回分子予防環境医学研究大会
    • Place of Presentation
      京都府立医科大学
    • Related Report
      2011 Final Research Report
  • [Presentation] Occupational health survey on factory handling titanium dioxide2010

    • Author(s)
      市原学
    • Organizer
      第20回日本MRS学術シンポジウム
    • Place of Presentation
      横浜情報文化センター
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] プロテオミクス技術を用いた1-ブロモプロパンによる中枢神経障害に関連するタンパク質の探索日本ヒトプロテオーム機構2010

    • Author(s)
      安藤知沙、市原佐保子、葛谷憲太郎、常杰、黄振烈、市原学、及川伸二
    • Organizer
      第8回大会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      千葉(東京ベイホテル東急)
    • Related Report
      2011 Final Research Report
  • [Presentation] Nrf2 null mice are more susceptible to 1-bromopropane-induced hepatotoxicity2010

    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Kitoh J, Ichihara G
    • Organizer
      The 49th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Saltlake city, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] N-acetyl-L-cysteine prevents the toxic effects of hyper phosphate mia and hypozincemia on the testicular function in WKY2010

    • Author(s)
      Suzuki Y, Ichihiara S, Kato A, Yamaguchi T, Yamada Y, Ichihara G.
    • Organizer
      The 49th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Saltlake city, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] プロテオミクス技術を用いた1-ブロモプロパンによる中枢神経障害に関連するタンパク質の探索2010

    • Author(s)
      安藤知沙、市原佐保子、葛谷憲太郎、常杰、黄振烈、市原学、及川伸二
    • Organizer
      日本ヒトプロテオーム機構第8回大会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      千葉(東京ベイホテル東急)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nrf2 null mice are more susceptible to 1-bromopropane-induced hepatotoxicity2010

    • Author(s)
      劉芳, ら
    • Organizer
      The 49th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Salt lake city, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] N-acetyl-L-cysteine prevents the toxic effects of hyperphosphatemia and hypozincemia on the testicular function in WKY, but not in SHR/NDmcr-cp, a model of metabolic syndrome2010

    • Author(s)
      Yuka Suzuki, ら
    • Organizer
      The 49th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Salt lake city, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1-ブロモプロパンの量依存的な神経、血液、生化学指標への影響-再解析による新しい知見2009

    • Author(s)
      張霊逸
    • Organizer
      平成21年度日本産業衛生学会産業神経・行動学研究会・日本衛生学会脳・神経学研究会・日本神経行動・毒性研究会
    • Place of Presentation
      順天堂大学医学部9号館2階8番教室
    • Year and Date
      2009-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒトにおける1-ブロモプロパンの量依存的な神経、血液、生化学指標への影響-再解析による新しい知見-2009

    • Author(s)
      張霊逸, ら
    • Organizer
      平成21年度日本産業衛生学会産業神経・行動学研究会・日本衛生学会脳・神経学研究会・日本神経行動・毒性研究会
    • Place of Presentation
      順天堂大学医学部9号館2階8番教室
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露によるヒト中枢神経病変の核磁気共鳴画像 (MRI) 解析2009

    • Author(s)
      近藤喜代太, ら
    • Organizer
      平成21年度日本産業衛生学会産業神経・行動学研究会・日本衛生学会脳・神経学研究会・日本神経行動・毒性研究会
    • Place of Presentation
      順天堂大学医学部9号館2階8番教室
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] High susceptibility of nrf2 mice to 1-bromopropane exposure2009

    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Kitoh J, Ichihara G
    • Organizer
      第37回有機溶剤中毒研究会、第42回生物学的モニタリング・バイオマーカー研究会合同研究会
    • Place of Presentation
      京都大学医学部医学・生命科学研究棟
    • Year and Date
      2009-10-17
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Epidemiological Study on workers handling titanium dioxide2009

    • Author(s)
      chihara G
    • Organizer
      Symposium on the social acceptance of nanomaterials, NIMS WEEK
    • Place of Presentation
      National Institute for Materials Science, Tsukuba, Japan
    • Year and Date
      2009-07-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Epidemiological Study on workers handling titanium dioxide2009

    • Author(s)
      Gaku Ichihara
    • Organizer
      Symposium on the social acceptance of nanomaterials, NIMS WEEK 2009
    • Place of Presentation
      National Institute for Materials Science, Tsukuba
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1-ブロモプロパン感受性の分子的基盤2009

    • Author(s)
      劉芳、市原佐保子、シェイクモヒディーンサハブディーン、崔雨佳、市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 1-ブロモプロパン中枢神経影響のDNAマイクロアレイ解析と中枢神経毒性バイオマーカーの探索.2009

    • Author(s)
      シェイクモヒディーンサハブディーン、黄芬、市原佐保子、北河恵美子、岩橋均、劉芳、市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] Exposure assessment and evaluation of health status in workers handling titanium dioxide2009

    • Author(s)
      Ichihara G, Li W, Fujitani Y, Ichihara S, DingX, Liu Y, Wang Q, Sai U, Hata N, Kobayashi T
    • Organizer
      The 4th International Conference on Nanotechnology
    • Place of Presentation
      Helsinki, Finland
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 1-ブロモプロパンの神経毒性と血液毒性のヒト量ー反応関係に関する研究2009

    • Author(s)
      李衛華、陳波、劉穎、林靖彦、宋偉民、市原佐保子、丁訓誠、市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] 多層カーボンナノチューブ気管内投与の肺に対する影響.2009

    • Author(s)
      劉穎、李衛華、陳波、林靖彦、市原佐保子、丁訓誠、市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] ストレス応答に関与する転写因子Nrf2の血管新生における役割の解明2009

    • Author(s)
      市原佐保子、山本雅之、伊東健、市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] マウスRAW264. 7マクロファージとヒトA549肺細胞を用いた多層カーボンナノチューブが誘導する酸化ストレスの評価2009

    • Author(s)
      陳波、李衛華、劉穎、林靖彦、宋偉民、市原佐保子、丁訓誠、市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] Balb/cAはC57BL/6JやDBA/2Jよりも1ブロモプロパン曝露に対して感受性が高い2009

    • Author(s)
      劉芳,市原佐保子, Sheik Mohideen Sahabudeen,崔雨佳,市原学
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      北里大学白金キャンパス
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露によるラット脳遺伝子発現変化に関するマイクロアレイ研究2009

    • Author(s)
      Sheik Mohideen Sahabudeen,黄芬,市原佐保子,北河恵美子,岩橋均,劉芳,市原学
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      北里大学白金キャンパス
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 1-ブロモプロパン中枢神経影響のDNAマイクロアレイ解析と中枢神経毒性バイオマーカーの探索2009

    • Author(s)
      シェイクモヒディーン・サハブディーン, ら
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1-ブロモプロパンの神経毒性と血液毒性のヒト量-反応関係に関する研究2009

    • Author(s)
      李衛華, ら
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多層カーボンナノチューブ気管内投与の肺に対する影響2009

    • Author(s)
      劉穎, ら
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスRAW264.7マクロファージとヒトA549肺細胞を用いた多層カーボンナノチューブが誘導する酸化ストレスの評価2009

    • Author(s)
      陳波, ら
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] 太ら. 1-ブロモプロパン曝露によるヒト中枢神経病変の核磁気共鳴画像(MRI)解析

    • Author(s)
      近藤喜代
    • Organizer
      平成21年度日本産業衛生学会産業神経・行動学研究会・日本衛生学会脳・神経学研究会・日本神経行動・毒性研究会
    • Place of Presentation
      順天堂大学医学部9号館2階8番教室
    • Related Report
      2011 Final Research Report
  • [Book] 労働科学研究所産業安全保健ハンドブック5. 44生殖次世代影響2012

    • Author(s)
      市原学
    • Related Report
      2011 Final Research Report
  • [Book] 産業安全保健ハンドブック5.44生殖次世代影響2012

    • Author(s)
      市原学
    • Publisher
      労働科学研究所(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] カーボンナノチューブ・グラフェンハンドブック2011

    • Author(s)
      市原学
    • Total Pages
      368
    • Publisher
      コロナ社
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] ナノカーボンの応用と実用化-フラーレン、ナノチューブ、グラフェンを中心に-2011

    • Author(s)
      市原学
    • Total Pages
      302
    • Publisher
      シーエムシー篠原久典監修
    • Related Report
      2011 Final Research Report
  • [Book] ナノカーボンの応用と実用化-フラーレン、ナノチューブ、グラフェンを中心に-(篠原久典監修)2011

    • Author(s)
      市原学
    • Total Pages
      302
    • Publisher
      シーエムシー
    • Related Report
      2011 Annual Research Report
  • [Book] 「ナノ材料の安全性-世界最前線」ナノファイバー学会監修2010

    • Author(s)
      市原学シーエムシー
    • Total Pages
      319
    • Related Report
      2011 Final Research Report
  • [Book] ナノ材料のリスク, 評価と安全性対策-生体・環境への影響、安全性対策・国内外動向2010

    • Author(s)
      市原学
    • Total Pages
      317
    • Publisher
      フロンティア出版
    • Related Report
      2011 Final Research Report
  • [Book] ナノ材料のリスク評価と安全性対策-生体・環境への影響、安全性対策・国内外動向2010

    • Author(s)
      市原学
    • Total Pages
      317
    • Publisher
      フロンティア出版
    • Related Report
      2010 Annual Research Report
  • [Book] 工業ナノ素材の環境、健康、安全性研究戦略と労働現場におけるナノ粒子測定、健康調査、ナノ材料のリスク評価と安全性対策2010

    • Author(s)
      市原学
    • Publisher
      フロンティア出版(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://kenpro.mynu.jp:8001/Profiles/0006/0000652/profile.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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