Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans
| Project/Area Number |
21406017
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
ICHIHARA Gaku 名古屋大学, 大学院・医学系研究科, 准教授 (90252238)
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| Co-Investigator(Kenkyū-buntansha) |
WAKAI Kenji 名古屋大学, 大学院・医学系研究科, 准教授 (50270989)
市原 佐保子 見え大学, 地域イノベーション学研究科, 准教授 (20378326)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | ブロモプロパン / 神経毒性 / 量反応関係 / 1-ブロモプロパン / 中枢神経毒性 / 振動覚 / 労働衛生調査 / MRI / 多発性硬化症 / 量反応性 / 中毒症例 / 疫学調査 / 血液毒性 / 中枢神経 / 分子疫学 |
|---|
| Research Abstract |
The analysis of workers exposed to 1-bromopropane and non-exposed workers was conducted using ANOVA followed by Dunnett's multiple comparison and regression analysis. The result showed dose-dependent increase in distal latency, threshold for vibration sense, LDH, TSH, FSH and dose-dependent decrease in sensory nerve conduction velocity, red blood cell, hematocrit. The cases intoxicated with 1-bromopropane showed degeneration of peripheral nerve histopathologically and the abnormality in the central nervous system.
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Report
(4 results)
Research Products
(160 results)
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[Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane2010
Author(s)
Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G
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Journal Title
Journal of Occupational and Environmental Medicine
Volume: 52
Pages: 769-777
Related Report
Peer Reviewed
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[Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromo propane.2010
Author(s)
Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G.
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Journal Title
Journal of Occupational and Environmental Medicine
Volume: 52
Pages: 769-777
Related Report
Peer Reviewed
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[Presentation] Dose-dependent neurologic abnormalities in workers exposed to 1-bromo propane2010
Author(s)
G.Ichihara, W.Li, E..Shibata, Z.Zhou, S.Ichihara, H.Wang, Q.Wang, J.Li, L..Zhang, Y.Takeuchi, X.Ding
Organizer
XII International Congress of Toxicology
Place of Presentation
Barcelona, Spain
Year and Date
2010-07-20
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[Presentation] Exposure assessment and evaluation of health status in workers handling titanium dioxide2009
Author(s)
Ichihara G, Li W, Fujitani Y, Ichihara S, DingX, Liu Y, Wang Q, Sai U, Hata N, Kobayashi T
Organizer
The 4th International Conference on Nanotechnology
Place of Presentation
Helsinki, Finland
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