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Clinical and microbiological research on Streptococcus suis infection in Thailand

Research Project

Project/Area Number 21406027
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Infectious disease medicine
Research InstitutionOsaka University

Principal Investigator

OISHI Kazunori  大阪大学, 微生物病研究所, 特任教授 (80160414)

Co-Investigator(Kenkyū-buntansha) AKEDA Yukihiro  大阪大学, 微生物病研究所, 特任講師 (60444527)
NAKAYAMA Tatsuya  大阪大学, 微生物病研究所, 特任研究員 (80552158)
IIDA Tetsuya  大阪大学, 微生物病研究所, 特任教授 (90221746)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywordsブタレンサ球菌 / 髄膜炎 / 敗血症 / タイ王国 / 人獣共通感染症 / 食の安全 / タイ国 / ブタレンサ球菌感染症
Research Abstract

Clinical and microbiological research on Streptococcus suis infection in Thailand
Of 179 human cases whose bacterial cultures for blood and/ or cerebrospinal fluid were positive for Streptococcus suis during 2006-2008 in Thailand, the major pathogens are serotype 2(92. 2%), followed by serotype 14(6. 7%). Previously unreported cases caused by serotype 5 and 24 were also confirmed. 58. 9% of human cases with serotype 2 was meningitis. The major sequence type(ST) 1 strains were significantly associated with the meningitis. In a study in Phayao province in 2010, the estimated incidence rate was 6. 2 per 100, 000 in the general population. Consumption of raw pork products was confirmed in 22 cases(71%) and the incubation period was 2 days after consumption of raw pork products.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (11 results) Remarks (3 results)

  • [Journal Article] Population-based Study of Streptococcus suis Infection in Humans in Phayao Province in Northern Thailand2012

    • Author(s)
      Takeuchi D, Kerdsin A, Pienpringam A, Loetthong P, Samerchea S, Pakkinee Loetthong P, Khamisra K, Wongwan N, Areeratana P, Chiranairadul P, Lertchayanti S, Petcharat S, Yowang A, Chaiwongsaen P, Nakayama T, Akeda Y, Hamada S, Sawanpanyalert P, Dejsirilert
    • Journal Title

      PLoS ONE

      Volume: 7(2) Issue: 2 Pages: e31265-e31265

    • DOI

      10.1371/journal.pone.0031265

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genotypic profile of Streptococcus suis serotype 2 and clinical features of infection in humans, Thailand2011

    • Author(s)
      Kerdsin A, Dejsirilert S, Puangpatra P, Sripakdee S, Chumla K, Boonkerd N, Polwichai P, Tanimura S, Takeuchi D, Nakayama T, Nakamura S, Akeda Y, Gottschalk M, Sawanpanyalert P, Oishi K
    • Journal Title

      Emerg Infect Dis

      Volume: 17 Issue: 5 Pages: 835-842

    • DOI

      10.3201/eid1705.100754

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sepsis and spontaneous bacterial peritonitis in Thailand2011

    • Author(s)
      Kerdsin A, Dejsirilert S, Sawanpanyalert P, Boonnark A, Noithachang W, Sriyakun D, Simkum S, Chokngam S, Gottschalk M, Akeda Y, Oishi K
    • Journal Title

      Lancet

      Volume: 378 Issue: 9794 Pages: 960-960

    • DOI

      10.1016/s0140-6736(11)60923-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sepsis and spontaneous bacterial peritonitis in Thailand2011

    • Author(s)
      Kerdsin A, et al
    • Journal Title

      Lancet

      Volume: 378 Pages: 960-960

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotypic profile of Streptococcus suis serotype 2 and clinical features of Infection in humans, Thailand2011

    • Author(s)
      Kerdsin A, et al.
    • Journal Title

      Emerging Infect Dis

      Volume: 17(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Streptococcus suis infection induces bacterial accumulation in the kidney2011

    • Author(s)
      Nakayama T, et al.
    • Journal Title

      Microb Pathog

      Volume: 50 Pages: 87-93

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Streptococcus suis infection induces bacterial accumulation in the kidney2010

    • Author(s)
      Nakayama T, Takeuchi D, Akeda Y, Oishi K
    • Journal Title

      Microb Pathog

      Volume: 50 Pages: 87-93

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clonal dissemination of Streptococcus suis serotype 14 in Thailand2009

    • Author(s)
      Kerdsin A, Oishi K, Sripakdee S, Boonkerd N, Polwichai P, Nakamura S, Uchida R, Sawanpanyalert P, Dejsirilert S
    • Journal Title

      J Med Micrbiol

      Volume: 58 Pages: 1508-1513

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clonal Dissemination of Streptococcus suis serotype 14 in Thailand.2009

    • Author(s)
      Kerdsin A, et al
    • Journal Title

      Journal Medical Microbiology 58

      Pages: 1508-1513

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 東南アジアで注目されるブタ連鎖球菌感染症と伝統的食習慣2009

    • Author(s)
      大石和徳
    • Journal Title

      Clinical Parasitology 20

      Pages: 20-22

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Streptococcus suis infection in Thailand2012

    • Author(s)
      Takeuchi D, et al
    • Organizer
      Asian-African Research Forum on Emerging and Reemerging Infections 2012
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Association of haemolytic activity of human isolates of S. suis serotype 2 with their capacity of crossing the blood-CSF barrier2011

    • Author(s)
      Nakayama T, et al
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Association of haemolytic activity of human isolates of S.suis serotype 2 with their capacity of crossing the blood-CSF barrier2011

    • Author(s)
      Nakayama T, et al
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] Streptococcus suis infection in Thailand2011

    • Author(s)
      Takeuchi D, et al
    • Organizer
      Asian-African Research Forum on Emerging and Reemer ging Infections 2012
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] タイにおけるブタ連鎖球菌serotype 2感染症の臨床像と分子疫学2010

    • Author(s)
      中山達哉
    • Organizer
      日本感染症学会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 北タイにおける人獣共通感染症:S. suis感染症の実態2010

    • Author(s)
      竹内壇, 大石和徳
    • Organizer
      第51回日本熱帯医学会大会
    • Place of Presentation
      仙台
    • Related Report
      2011 Final Research Report
  • [Presentation] タイにおけるブタ連鎖球菌serotype2のゲノタイプと病型に関する検討2010

    • Author(s)
      中山達哉、竹内壇、明田幸宏、大石和徳
    • Organizer
      第53回日本感染症学会中日本地方
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical features of Streptococcus suis serotype 2 infections in relation to the genotypic profiles of isolates in Thailand2010

    • Author(s)
      Kerdsin A, Dejsirilert S, Puangpatra P, Sripakdee S, Chumla K, 1 Boonkerd N, Polwichai P, Tanimura S, Takeuchi D, Nakayama T, Nakamura S, Akeda Y, Gottschalk M, Sawanpanyalert P, Oishi K
    • Organizer
      IDSA 48 th annual meeting. Vancouver
    • Place of Presentation
      Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] タイにおけるブタ連鎖球菌serotype 2感染症の臨床像と分子疫学2010

    • Author(s)
      中山達哉、明田幸宏、大石和徳
    • Organizer
      第50回日本呼吸器学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウム「食の安全と感染症」5.「東南アジアで注目されるブタ連鎖球菌感染症と伝統的食習慣」2009

    • Author(s)
      大石和徳
    • Organizer
      第20回日本臨床寄生虫学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-06-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 東南アジアで注目されるStreptococcus suis感染症2009

    • Author(s)
      大石和徳
    • Organizer
      第58回日本感染症学会、第56回日本化学療法学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/lab/CRID/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/lab/CRID/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/lab/CRID/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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