| Project/Area Number |
21406033
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Social dentistry
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| Research Institution | 公益財団法人神経研究所 (2011)
Neuropsychiatric Research Institute (2009-2010) |
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Principal Investigator |
TSUIKI Satoru 公益財団法人神経研究所, 研究部, 研究員 (90376765)
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| Co-Investigator(Kenkyū-buntansha) |
内藤 陽子 (駒田 陽子) (財)神経研究所, 研究部, 研究員 (40451380)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUEY Yuichi 公益財団法人神経研究所, 研究部, センター長 (50213179)
ISONO Shiroh 千葉大学, 医学研究科, 教授 (80212968)
MAEDA Keiko 公益財団法人神経研究所, 研究部, 研究員 (30529938)
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| Research Collaborator |
ALMEIDA Fernanda R. The University of British Columbia, Faculty of Dentistry, Assistant Professor
LOWE Alan A. The University of British Columbia, Faculty of Dentistry, Professor
RYAN Frank C. The University of British Columbia, Faculty of Medicine, Professor
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 閉塞性睡眠時無呼吸症候群 / 顎顔面形態 / 解剖学的バランス / 舌 / 日本人 / 白人 / 睡眠時無呼吸症候群 / 睡眠学 / 社会系歯学 / 上気道 |
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| Research Abstract |
Obesity and craniofacial abnormalities are common features of patients with Obstructive Sleep Apnea(OSA). Anatomical balance between the size of the craniofacial rigid enclosure(formed by the dentitions, cervical vertebrae, maxilla, and mandible) and the amount of soft tissue(e. g. tongue) influences the upper airway space and is involved in the pathogenesis of OSA. In this study, we investigated whether this anatomical balance was different between races in OSA people. Blind measurements of tongue cross-sectional area and craniofacial dimensions were performed two dimensionally through lateral cephalograms in 76 Japanese patients with OSA and 74 Caucasian OSA subjects after matching gender(male), age, and apnea hypopnea index. Sagittal tongue size, sagittal maxillomandibular dimensions, and body mass index(BMI) were compared between the groups. While BMI was significantly higher in Caucasians than in Japanese patients, tongue size and maxillomandibular dimensions were not different between the races. These findings suggest that anatomical balance does not differ between Japanese OSA people and Caucasian OSA persons under the same OSA severity. This may partly account for the reason why prevalence of OSA are almost the same between Japanese and Caucasians.
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