Finding Medical Knowledge from Clinical Data based on Interpretations

• Project/Area Number: 21500135
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Intelligent informatics
• Research Institution: Japan Advanced Institute of Science and Technology
• Principal Investigator: KAWASAKI Saori 北陸先端科学技術大学院大学, 先端領域社会人教育院, 特任准教授 (40377437)
• Co-Investigator(Kenkyū-buntansha): TU Bao Ho 北陸先端科学技術大学院大学, 知識科学研究科, 教授 (60301199)
• Co-Investigator(Renkei-kenkyūsha): TAKABAYASHI Katsuhiko 千葉大学, 医学部附属病院, 教授 (90188079) ; KANDA Tatsuo 千葉大学, 医学研究院, 特任講師 (20345002)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: データマイニング / 医療データ / 専門知識 / 後処理 / 解釈モデル / 準教師付学習 / 医学的知識

Research Abstract

The focus of this research is to obtain more interesting mining results for the medical experts, so that not only the data mining from the target clinical data itself but also the combining the background knowledge extraction from medical litarature and experts’interpretations have been pursued in finding the relationships among blood tests and the treatment effects. dditionally, in accordance with the high attention to sequence analysis in biomedicine, semi-supervised learning methods specially for the virus subgenotypes and the interferon/ribavirin treatments were developed to show the potentials of computational approaches.

Research Products

• [Journal Article] Quantitatively assessing the effect of regulatory factors on nucleosome dynamics, Journal of Ambient Intelligence and Humanized Computing (2013)
  • Author(s): Ho, B.H., Le, N.T., Ho, T.B.
  • Journal Title: Peer Reviewed Volume: Vol. 3, Issue 4 Pages: 265-280
  • Peer Reviewed
• [Journal Article] Detecting Disease Genes Based on Semi-Supervised Learning and Protein-Protein Interaction Networks, Artificial Intelligence in Medicine (2013)
  • Author(s): Nguyen, T.P., Ho, T.B.
  • Journal Title: Peer Reviewed Volume: Vol. 54 Pages: 63-71
  • Peer Reviewed
• [Journal Article] A Semi-Supervised Learning Method for Discriminative Motif Finding and Its Application (2013)
  • Author(s): Le, N.
  • Journal Title: Journal of Universal Computer Science Volume: 19
  • Peer Reviewed
• [Journal Article] A Semi-Supervised Learning Method for Discriminative Motif Finding and Its Application, Journal of Universal Computer Science (2012)
  • Author(s): Le, N., Ho, T.B., Kanda, T., Kawasaki,S., Takabayashi, K., Wu, S., Yokosaka,O.
  • Journal Title: peer reveiwed Volume: Vol.19-No.4 Pages: 563-580
  • Peer Reviewed
• [Journal Article] Sequence-dependent histone variant positioning signatures, BMC Genomics (2011)
  • Author(s): Le, N.T., Ho, T.B., Ho, B.H.
  • Journal Title: Peer reviewed Volume: Vol. 11 (Suppl 4) Pages: 1-9
  • Peer Reviewed
• [Journal Article] Enhancing Privacy in Distributed Data Clustering,Journal of Computer Science and Cybernetics (2011)
  • Author(s): Luong, T.D., Ho, T.B.
  • Journal Title: peer Reviewed Volume: Vol. 26, No.2 Pages: 1-15
  • Peer Reviewed
• [Journal Article] Discovering Relationship between Hepatitis C Virus NS5A Protein and Interferon/Ribavirin Therapy,Knowledge, Information and Creativity Support Systems KICSS2010 Revised Selected Papers (2011)
  • Author(s): Kawasaki, S., Ho, T.B., Kanda, T.
  • Journal Title: Peer Reviewed Volume: LNAI6746 Pages: 79-90
  • Peer Reviewed
• [Journal Article] Discovering Relationship between Hepatitis C Virus NS5A Protein and Interferon/Ribavirin Therapy (2011)
  • Author(s): Kawasaki, S., Ho, T.B., Kanda, T.
  • Journal Title: Post proceedings of KICSS2010 Volume: LNCS, Springer
  • Peer Reviewed
• [Journal Article] Sequence-dependent histone variant positioning signatures (2010)
  • Author(s): Le, N.T., Ho, T.B., Ho, B.H.
  • Journal Title: BMC Genomics Volume: Vol.11(Suppl4) Pages: 1-9
  • NAID: 120003338958
  • Peer Reviewed
• [Journal Article] Enhancing Privacy in Distributed Data Clustering (2010)
  • Author(s): Luong, T.D., Ho, T.B.
  • Journal Title: Journal of Computer Science and Cybernetics Volume: Vol.26, No.2 Pages: 1-15
  • Peer Reviewed
• [Journal Article] Detecting Disease Genes Based on Semi-Supervised Learning and Protein-Protein Interaction Networks (cond. accepted) (2010)
  • Author(s): Nguyen, T.P., Ho, T.B.
  • Journal Title: Artificial Intelligence in Medicine (印刷中)
  • Peer Reviewed
• [Journal Article] Characterizing nucleosome dynamics from genomic and epigenetic information using rule induction learning, BMC enomics (2009)
  • Author(s): Le, N.T., Ho, T.B., Tran, D.H.
  • Journal Title: Peer Reviewed Volume: Vol.10(Suppl.3)
  • Peer Reviewed
• [Journal Article] Characterizing nucleosome dynamics from genomic and epigenetic information using rule induction learning (2009)
  • Author(s): Le, N.T., Ho, T.B., Tran, D.H.
  • Journal Title: BMC Genomics 10 (Suppl. 3)
  • NAID: 120002511611
  • Peer Reviewed
• [Presentation] An Effective Method for Generating siRNA Design Rules (2013)
  • Author(s): Bui, N.T., Ho, T.B., Kawasaki, S.
  • Organizer: The 5th Asian Conference On Intelligent Information and Database Systems, ACIID 2013(LNAI 7803 pp.196-205)
  • Place of Presentation: Kuala Lumpur/Malasia
• [Presentation] An Effective Method for Generating siRNA Design Rules (2013)
  • Author(s): Le, N.T.
  • Organizer: The 5th Asian Conference On Intelligent Information and Database Systems, ACIID 2013
  • Place of Presentation: マレーシア／クアラルンプール
• [Presentation] From Clinical to Genomics Data in Hepatitis Study (2012)
  • Author(s): Ho, T.B., Takabayashi, T., Kanda, T.,Kawasaki, S., Le, T.N., Bui, N.T., Than,Q.K.
  • Organizer: The First Asian Conference on Information Systems
  • Place of Presentation: Siem Reap/Cambodia
• [Presentation] A Sequential Apriori Algorithm for Discriminative Design Rules of Effective siRNA Sequences (2012)
  • Author(s): Bui, N.T., Ho, T.B., Kawasaki, S.
  • Organizer: 13th International Symposium on Knowledge and Systems Science
  • Place of Presentation: 石川県金沢市
• [Presentation] Supervised dimension reduction with topic model (2012)
  • Author(s): Than, K., Pham. N.K., Nguyen, D.K., Ho,T.B.
  • Organizer: 4th Asian Conference on Machine Learning 2012
  • Place of Presentation: Singapore/ Singapore
• [Presentation] A Semi-Supervised Method for Discriminative Motif Finding and Its Application to Hepatitis C Virus Study (2012)
  • Author(s): Le, N., Ho, T.B.
  • Organizer: 4th Asian Conference on Intelligent Information and Database Systems ACIIDS 2012
  • Place of Presentation: Kaohsiung/Taiwan
• [Presentation] A Semi-Supervised Method for Discriminative Motif Finding and Its Application to Hepatitis C Virus Study (2012)
  • Author(s): Le, N
  • Organizer: 4th Asian Conference on Intelligent Information and Database Systems ACIIDS 2012
  • Place of Presentation: 台湾／高雄
• [Presentation] A Sequential Apriori Algorithm for Discriminative Design Rules of Effective siRNA Sequences (2012)
  • Author(s): Bui, N.T
  • Organizer: 13th International Symposium on Knowledge and Systems Science
  • Place of Presentation: 金沢市
• [Presentation] From Clinical to Genomics Data in Hepatitis Study (2012)
  • Author(s): Ho, T.B.
  • Organizer: The First Asian Conference on Information Systems
  • Place of Presentation: カンボジア／シェムリアップ
• [Presentation] Finding HCV NS5A Discriminative Motifs for Assessment of IFN/Ribavarin Therapy Effect, Workshop Data Mining in Genomics and Proteomics (2011)
  • Author(s): Ho, T.B., Kawasaki, S., Le, N.T., Kanda,T., Le, T.N., Takabayashi, K., Yokosuka,O.
  • Organizer: International Conference ECML/PKDD(pp.32-42)
  • Place of Presentation: Athens/Greece
• [Presentation] Finding HCV NS5A Discriminative Motifs for Assessment of IFN/Ribavirin Therapy Effect (2011)
  • Author(s): Ho, T.B
  • Organizer: Workshop Data Mining in Genomics and Proteomics, International Conference ECML/PKDD
  • Place of Presentation: ギリシャ／アテネ
• [Presentation] Mining parallel documents across Web sites (2010)
  • Author(s): Pham, N.K., Ho, T.B.
  • Organizer: The Sixth Asia Information Retrieval Societies Conference AIRS 2010
  • Place of Presentation: Taipei.Taiwan
• [Presentation] Discovering Relationship between Hepatitis C Virus NS5A Protein and Interferon/Ribavirin Therapy (2010)
  • Author(s): Kawasaki, S., Ho, T.B., Kanda, T.,Yokosuka, O., Takabayashi, K., Le, T.N.
  • Organizer: Fifth International Conference on Knowledge,Information and Creativity Support Systems KICSS'10
  • Place of Presentation: ChiangMai/Thailand
• [Presentation] Discovering Relationship between Hepatitis C Virus NS5A Protein and Iriterferon/Ribavirin Therapy (2010)
  • Author(s): Kawasaki, S., Ho, T.B., Kanda, T., Yokosuka, O., Takabayashi, K., Le, T.N.
  • Organizer: Fifth International Conference on Knowledge, Information and Creativity Support Systems KICSS'10
  • Place of Presentation: チェンマイ(タイ)
• [Presentation] Mining parallel documents across Web sites (2010)
  • Author(s): Pham, N.K., Ho, T.B.
  • Organizer: The Sixth Asia Information Retrie val Societies Conference AIRS 2010
  • Place of Presentation: 台北市(台湾)
• [Presentation] Quantitatively assessing the effect of regulatory factots on nu cleosome dynamics (2010)
  • Author(s): Ho, B.h, Le, N.T., Ho, T.B.
  • Organizer: EEERIVF Interna tional Conference on Computing and Communication Techologied
  • Place of Presentation: ハノイ(ベトナム)
• [Presentation] Towards service-oriented knowledge discovery in biomedicine research (2009)
  • Author(s): Ho, T.B., Takabayashi, K., Pham, T.H. ,Nguyen, T.P., Kawasaki, S., Tran, D.H.
  • Organizer: International Workshop on Third Generation Data Mining, ECML/PKDD 2009(pp.100-113)
  • Place of Presentation: Bled/Slovenia
  • Year and Date: 2009-07-11
• [Presentation] Quantitatively assessing the effect of regulatory factors on nucleosome dynamics (2009)
  • Author(s): Ho, B.H., Le, N.T., Ho, T.B.
  • Organizer: IEEE-RIVF International Conference on Computing and Communication Technologies
  • Place of Presentation: Hanoi/Vietnam
• [Presentation] Towards service-oriented knowledge discovery in biomedicine Research (2009)
  • Author(s): Ho, T.B., Takabayashi, K., Pham T.H., Nguyen, T.P., Kawasaki, S., Tran, D.H.
  • Organizer: International Workshop on Third Generation Data Mining, ECMLIPKDD 2009
  • Place of Presentation: Bled, Slovenia
• [Presentation] Privacy preserving EM-based Clustering (2009)
  • Author(s): Luong, T.D., Ho, T.B.
  • Organizer: IEEE RIVF International Conference on Computing and Communication Technologies
  • Place of Presentation: Da Nang, Viet Nam
• [Book] Knowledge Discovery (Chapter 4 of,Knowledge Technology and Science edited by Y. Nakamori) (2011)
  • Author(s): Ho, T.B.
  • Publisher: CRC Press and Taylor & Francis
• [Book] Mining multiple biological data for reconstructing signal transduction networks (Data Mining: Foundations and Intelligent Paradigms edited by D.E.Holmes & L.C. Jain) (2011)
  • Author(s): Nguyen, T.P., Ho, T.B.
  • Publisher: Springer-Verlag
• [Book] Advances in Knowledge Discovery and Data Mining (Eds.), Proceedings of the 13th Pacific-Asia Conference on Knowledge Discovery and Data Mining, Lecture Notes in Artificial Intelligence LNAI 5476 (2009)
  • Author(s): Theramunkong, T., Kijsirikul, B, Cercone, N., Ho, T.B. 編
  • Total Pages: 1076
  • Publisher: Springer