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Finding Medical Knowledge from Clinical Data based on Interpretations

Research Project

Project/Area Number 21500135
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent informatics
Research InstitutionJapan Advanced Institute of Science and Technology

Principal Investigator

KAWASAKI Saori  北陸先端科学技術大学院大学, 先端領域社会人教育院, 特任准教授 (40377437)

Co-Investigator(Kenkyū-buntansha) TU Bao Ho  北陸先端科学技術大学院大学, 知識科学研究科, 教授 (60301199)
Co-Investigator(Renkei-kenkyūsha) TAKABAYASHI Katsuhiko  千葉大学, 医学部附属病院, 教授 (90188079)
KANDA Tatsuo  千葉大学, 医学研究院, 特任講師 (20345002)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsデータマイニング / 医療データ / 専門知識 / 後処理 / 解釈モデル / 準教師付学習 / 医学的知識
Research Abstract

The focus of this research is to obtain more interesting mining results for the medical experts, so that not only the data mining from the target clinical data itself but also the combining the background knowledge extraction from medical litarature and experts’interpretations have been pursued in finding the relationships among blood tests and the treatment effects. dditionally, in accordance with the high attention to sequence analysis in biomedicine, semi-supervised learning methods specially for the virus subgenotypes and the interferon/ribavirin treatments were developed to show the potentials of computational approaches.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (36 results)

All 2013 2012 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (20 results) Book (3 results)

  • [Journal Article] Quantitatively assessing the effect of regulatory factors on nucleosome dynamics, Journal of Ambient Intelligence and Humanized Computing2013

    • Author(s)
      Ho, B.H., Le, N.T., Ho, T.B.
    • Journal Title

      Peer Reviewed

      Volume: Vol. 3, Issue 4 Pages: 265-280

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detecting Disease Genes Based on Semi-Supervised Learning and Protein-Protein Interaction Networks, Artificial Intelligence in Medicine2013

    • Author(s)
      Nguyen, T.P., Ho, T.B.
    • Journal Title

      Peer Reviewed

      Volume: Vol. 54 Pages: 63-71

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Semi-Supervised Learning Method for Discriminative Motif Finding and Its Application2013

    • Author(s)
      Le, N.
    • Journal Title

      Journal of Universal Computer Science

      Volume: 19

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Semi-Supervised Learning Method for Discriminative Motif Finding and Its Application, Journal of Universal Computer Science2012

    • Author(s)
      Le, N., Ho, T.B., Kanda, T., Kawasaki,S., Takabayashi, K., Wu, S., Yokosaka,O.
    • Journal Title

      peer reveiwed

      Volume: Vol.19-No.4 Pages: 563-580

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequence-dependent histone variant positioning signatures, BMC Genomics2011

    • Author(s)
      Le, N.T., Ho, T.B., Ho, B.H.
    • Journal Title

      Peer reviewed

      Volume: Vol. 11 (Suppl 4) Pages: 1-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancing Privacy in Distributed Data Clustering,Journal of Computer Science and Cybernetics2011

    • Author(s)
      Luong, T.D., Ho, T.B.
    • Journal Title

      peer Reviewed

      Volume: Vol. 26, No.2 Pages: 1-15

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Discovering Relationship between Hepatitis C Virus NS5A Protein and Interferon/Ribavirin Therapy,Knowledge, Information and Creativity Support Systems KICSS2010 Revised Selected Papers2011

    • Author(s)
      Kawasaki, S., Ho, T.B., Kanda, T.
    • Journal Title

      Peer Reviewed

      Volume: LNAI6746 Pages: 79-90

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Discovering Relationship between Hepatitis C Virus NS5A Protein and Interferon/Ribavirin Therapy2011

    • Author(s)
      Kawasaki, S., Ho, T.B., Kanda, T.
    • Journal Title

      Post proceedings of KICSS2010

      Volume: LNCS, Springer

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequence-dependent histone variant positioning signatures2010

    • Author(s)
      Le, N.T., Ho, T.B., Ho, B.H.
    • Journal Title

      BMC Genomics

      Volume: Vol.11(Suppl4) Pages: 1-9

    • NAID

      120003338958

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancing Privacy in Distributed Data Clustering2010

    • Author(s)
      Luong, T.D., Ho, T.B.
    • Journal Title

      Journal of Computer Science and Cybernetics

      Volume: Vol.26, No.2 Pages: 1-15

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detecting Disease Genes Based on Semi-Supervised Learning and Protein-Protein Interaction Networks (cond. accepted)2010

    • Author(s)
      Nguyen, T.P., Ho, T.B.
    • Journal Title

      Artificial Intelligence in Medicine (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterizing nucleosome dynamics from genomic and epigenetic information using rule induction learning, BMC enomics2009

    • Author(s)
      Le, N.T., Ho, T.B., Tran, D.H.
    • Journal Title

      Peer Reviewed

      Volume: Vol.10(Suppl.3)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterizing nucleosome dynamics from genomic and epigenetic information using rule induction learning2009

    • Author(s)
      Le, N.T., Ho, T.B., Tran, D.H.
    • Journal Title

      BMC Genomics 10 (Suppl. 3)

    • NAID

      120002511611

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] An Effective Method for Generating siRNA Design Rules2013

    • Author(s)
      Bui, N.T., Ho, T.B., Kawasaki, S.
    • Organizer
      The 5th Asian Conference On Intelligent Information and Database Systems, ACIID 2013(LNAI 7803 pp.196-205)
    • Place of Presentation
      Kuala Lumpur/Malasia
    • Related Report
      2011 Final Research Report
  • [Presentation] An Effective Method for Generating siRNA Design Rules2013

    • Author(s)
      Le, N.T.
    • Organizer
      The 5th Asian Conference On Intelligent Information and Database Systems, ACIID 2013
    • Place of Presentation
      マレーシア/クアラルンプール
    • Related Report
      2011 Annual Research Report
  • [Presentation] From Clinical to Genomics Data in Hepatitis Study2012

    • Author(s)
      Ho, T.B., Takabayashi, T., Kanda, T.,Kawasaki, S., Le, T.N., Bui, N.T., Than,Q.K.
    • Organizer
      The First Asian Conference on Information Systems
    • Place of Presentation
      Siem Reap/Cambodia
    • Related Report
      2011 Final Research Report
  • [Presentation] A Sequential Apriori Algorithm for Discriminative Design Rules of Effective siRNA Sequences2012

    • Author(s)
      Bui, N.T., Ho, T.B., Kawasaki, S.
    • Organizer
      13th International Symposium on Knowledge and Systems Science
    • Place of Presentation
      石川県金沢市
    • Related Report
      2011 Final Research Report
  • [Presentation] Supervised dimension reduction with topic model2012

    • Author(s)
      Than, K., Pham. N.K., Nguyen, D.K., Ho,T.B.
    • Organizer
      4th Asian Conference on Machine Learning 2012
    • Place of Presentation
      Singapore/ Singapore
    • Related Report
      2011 Final Research Report
  • [Presentation] A Semi-Supervised Method for Discriminative Motif Finding and Its Application to Hepatitis C Virus Study2012

    • Author(s)
      Le, N., Ho, T.B.
    • Organizer
      4th Asian Conference on Intelligent Information and Database Systems ACIIDS 2012
    • Place of Presentation
      Kaohsiung/Taiwan
    • Related Report
      2011 Final Research Report
  • [Presentation] A Semi-Supervised Method for Discriminative Motif Finding and Its Application to Hepatitis C Virus Study2012

    • Author(s)
      Le, N
    • Organizer
      4th Asian Conference on Intelligent Information and Database Systems ACIIDS 2012
    • Place of Presentation
      台湾/高雄
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Sequential Apriori Algorithm for Discriminative Design Rules of Effective siRNA Sequences2012

    • Author(s)
      Bui, N.T
    • Organizer
      13th International Symposium on Knowledge and Systems Science
    • Place of Presentation
      金沢市
    • Related Report
      2011 Annual Research Report
  • [Presentation] From Clinical to Genomics Data in Hepatitis Study2012

    • Author(s)
      Ho, T.B.
    • Organizer
      The First Asian Conference on Information Systems
    • Place of Presentation
      カンボジア/シェムリアップ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Finding HCV NS5A Discriminative Motifs for Assessment of IFN/Ribavarin Therapy Effect, Workshop Data Mining in Genomics and Proteomics2011

    • Author(s)
      Ho, T.B., Kawasaki, S., Le, N.T., Kanda,T., Le, T.N., Takabayashi, K., Yokosuka,O.
    • Organizer
      International Conference ECML/PKDD(pp.32-42)
    • Place of Presentation
      Athens/Greece
    • Related Report
      2011 Final Research Report
  • [Presentation] Finding HCV NS5A Discriminative Motifs for Assessment of IFN/Ribavirin Therapy Effect2011

    • Author(s)
      Ho, T.B
    • Organizer
      Workshop Data Mining in Genomics and Proteomics, International Conference ECML/PKDD
    • Place of Presentation
      ギリシャ/アテネ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mining parallel documents across Web sites2010

    • Author(s)
      Pham, N.K., Ho, T.B.
    • Organizer
      The Sixth Asia Information Retrieval Societies Conference AIRS 2010
    • Place of Presentation
      Taipei.Taiwan
    • Related Report
      2011 Final Research Report
  • [Presentation] Discovering Relationship between Hepatitis C Virus NS5A Protein and Interferon/Ribavirin Therapy2010

    • Author(s)
      Kawasaki, S., Ho, T.B., Kanda, T.,Yokosuka, O., Takabayashi, K., Le, T.N.
    • Organizer
      Fifth International Conference on Knowledge,Information and Creativity Support Systems KICSS'10
    • Place of Presentation
      ChiangMai/Thailand
    • Related Report
      2011 Final Research Report
  • [Presentation] Discovering Relationship between Hepatitis C Virus NS5A Protein and Iriterferon/Ribavirin Therapy2010

    • Author(s)
      Kawasaki, S., Ho, T.B., Kanda, T., Yokosuka, O., Takabayashi, K., Le, T.N.
    • Organizer
      Fifth International Conference on Knowledge, Information and Creativity Support Systems KICSS'10
    • Place of Presentation
      チェンマイ(タイ)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mining parallel documents across Web sites2010

    • Author(s)
      Pham, N.K., Ho, T.B.
    • Organizer
      The Sixth Asia Information Retrie val Societies Conference AIRS 2010
    • Place of Presentation
      台北市(台湾)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Quantitatively assessing the effect of regulatory factots on nu cleosome dynamics2010

    • Author(s)
      Ho, B.h, Le, N.T., Ho, T.B.
    • Organizer
      EEERIVF Interna tional Conference on Computing and Communication Techologied
    • Place of Presentation
      ハノイ(ベトナム)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Towards service-oriented knowledge discovery in biomedicine research2009

    • Author(s)
      Ho, T.B., Takabayashi, K., Pham, T.H. ,Nguyen, T.P., Kawasaki, S., Tran, D.H.
    • Organizer
      International Workshop on Third Generation Data Mining, ECML/PKDD 2009(pp.100-113)
    • Place of Presentation
      Bled/Slovenia
    • Year and Date
      2009-07-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Quantitatively assessing the effect of regulatory factors on nucleosome dynamics2009

    • Author(s)
      Ho, B.H., Le, N.T., Ho, T.B.
    • Organizer
      IEEE-RIVF International Conference on Computing and Communication Technologies
    • Place of Presentation
      Hanoi/Vietnam
    • Related Report
      2011 Final Research Report
  • [Presentation] Towards service-oriented knowledge discovery in biomedicine Research2009

    • Author(s)
      Ho, T.B., Takabayashi, K., Pham T.H., Nguyen, T.P., Kawasaki, S., Tran, D.H.
    • Organizer
      International Workshop on Third Generation Data Mining, ECMLIPKDD 2009
    • Place of Presentation
      Bled, Slovenia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Privacy preserving EM-based Clustering2009

    • Author(s)
      Luong, T.D., Ho, T.B.
    • Organizer
      IEEE RIVF International Conference on Computing and Communication Technologies
    • Place of Presentation
      Da Nang, Viet Nam
    • Related Report
      2009 Annual Research Report
  • [Book] Knowledge Discovery (Chapter 4 of,Knowledge Technology and Science edited by Y. Nakamori)2011

    • Author(s)
      Ho, T.B.
    • Publisher
      CRC Press and Taylor & Francis
    • Related Report
      2011 Final Research Report
  • [Book] Mining multiple biological data for reconstructing signal transduction networks (Data Mining: Foundations and Intelligent Paradigms edited by D.E.Holmes & L.C. Jain)2011

    • Author(s)
      Nguyen, T.P., Ho, T.B.
    • Publisher
      Springer-Verlag
    • Related Report
      2011 Final Research Report
  • [Book] Advances in Knowledge Discovery and Data Mining (Eds.), Proceedings of the 13th Pacific-Asia Conference on Knowledge Discovery and Data Mining, Lecture Notes in Artificial Intelligence LNAI 54762009

    • Author(s)
      Theramunkong, T., Kijsirikul, B, Cercone, N., Ho, T.B. 編
    • Total Pages
      1076
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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