Statistical Pattern Recognition in Small Sample Size Situations and its Application to Detection of Hepatocellular Carcinoma
| Project/Area Number |
21500173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Perception information processing/Intelligent robotics
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IIZUKA Norio 山口大学, 医学部付属病院, 准教授 (80332807)
FUJITA Yusuke 山口大学, 大学院・医学系研究科, 助教 (40509527)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 癌 / パターン認識 / 診断 |
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| Research Abstract |
The purpose of this study is to develop a novel blood test system for detecting hepatocellular carcinoma(HCC) associated with hepatitics C virus(HCV) infection. In order to develop the novel test system, we must establish a feature selection method to find effective bio-makers in small training sample size situations, compared with very high dimensions. We found 2 methylated genes(SPINT2 and SRD5A2). With use of 2 methylated genes, AFP. and PIVKA II. we designed the blood test system for detecting HCC, which achieved high abilities(73. 2% sensitivity and 87. 7% specificity) for 258 test samples provided from 4 institutes. This suggests that our blood test system might lead to clinical applications.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Efficient detection of hepatocellular carcinoma by a hybrido blood test of epigenetic and classical protein markers2011
Author(s)
N. Iizuka, M. Oka, I. Sakaida, T. Moribe, T. Miura, N. Kimura, S. Tamatsukuri, H. Ishitsuka, K. Uchida, S. Terai, S. Yamashita, K. Okita, K. Sakata, Y. Karino, J. Toyota, E. Ando, T. Ide, M. Sata, R. Tsunedomi, M. Tsutsui, M. Iida, Y. Tokuhisa, K. Sakamoto, T. Tamesa, Y. Fujita, Y. Hamamoto
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Journal Title
Clinica Chimica Acta
Volume: 412
Pages: 152-158
Related Report
Peer Reviewed
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[Journal Article] Methylated cyclin D2 gene circulating in the blood as a prognosis predictor of hepatocellular carcinoma2010
Author(s)
M. Tsutsui, N. Iizuka, T. Moribe, T. Miura, N. Kimura, S. Tamatsukuri, H. Ishitsuka, Y. Fujita, Y. Hamamoto, R. Tsunedomi, M. Iida, Y. Tokuhisa, K. Sakamoto, T. Tamesa, I. Sakaida and M. Oka
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Journal Title
Clinica Chimica Acta
Volume: 411
Pages: 516-520
Related Report
Peer Reviewed
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