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Semiparametric inference for censored data and its applications

Research Project

Project/Area Number 21500286
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Statistical science
Research InstitutionKurume University

Principal Investigator

HATTORI Satoshi  久留米大学, バイオ統計センター, 准教授 (50425154)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords医薬生物 / ゲノム統計解析 / 生存時間解析 / 生物統計 / 頑健推測 / モデル選択
Research Abstract

In clinical trials, estimation of the treatment effect relies on some assumptions for statistical models. Violation of the assumptions may lead to difficulty to interpret results of the statistical analysis. In this research, we propose a method, which is interpretable in the presence of the violation. In addition, it is desirable to incorporate covariate information to draw more precise inference. We develop a method efficiently utilizing covariate information to increase statistical precision.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010 2009 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (15 results) Book (2 results)

  • [Journal Article] Estimation of treatment effects based on possibly misspecified Cox regression2012

    • Author(s)
      Hattori S and Henmi M
    • Journal Title

      Lifetime Data Analysis

      Volume: (印刷中) Issue: 4 Pages: 408-433

    • DOI

      10.1007/s10985-012-9222-8

    • Year and Date
      2012-04-21
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Testing the no-treatment effect based on a possibly misspecified accelerated failure time model2012

    • Author(s)
      Hattori S
    • Journal Title

      Statistics and Probability Letters

      Volume: 82(2)巻 Issue: 2 Pages: 371-377

    • DOI

      10.1016/j.spl.2011.10.016

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determining amino acid requirements from repeated observations on indicator amino acid oxidation method by mixed-effect change-point regression models.2011

    • Author(s)
      Kohsuke Hayamizu
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mantel-Haenszel estimators for irregular sparse K 2xJ tables2010

    • Author(s)
      Hattori S and Yanagawa T
    • Journal Title

      Journal of Statistical Planning and Inference

      Volume: 140巻 Issue: 9 Pages: 2425-2432

    • DOI

      10.1016/j.jspi.2010.02.015

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mantel-Haenszel estimators for irregular sparse K 2xJ tables.2010

    • Author(s)
      Satoshi Hattori
    • Journal Title

      Journal of Statistical Planning and Inference

      Volume: 140 Pages: 2425-2432

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mantel-Haenszel estimators for irregular sparse K 2xJ tables2010

    • Author(s)
      服部聡
    • Journal Title

      Journal of Statistical Planning & Inference (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Approximate subject-deletion influence diagnostics for Inverse Probability of Censoring Weighted(IPCW) method2009

    • Author(s)
      Hattori S and Kato M
    • Journal Title

      Statistics and Probability Letters

      Volume: 79 Issue: 17 Pages: 1833-1838

    • DOI

      10.1016/j.spl.2009.05.013

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regression diagnostics of the semiparametric proportional rate model for irregularly-spaced repeated measurements2009

    • Author(s)
      Hattori S
    • Journal Title

      Communications in Statistics, Theory and Methods

      Volume: 38 Pages: 542-559

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生存時間解析におけるセミパラメトリック推測とその周辺2009

    • Author(s)
      服部聡
    • Journal Title

      統計数理

      Volume: 57 Pages: 119-138

    • NAID

      120006018981

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regression diagnostics of the semiparametric proportional rate model for irregularly-spaced repeated measurements2009

    • Author(s)
      服部聡
    • Journal Title

      Communications in Statistics, Theory and Methods 38

      Pages: 542-559

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Approximate subject-deletion influence diagnostics for Inverse Probability of Censoring Weighted(IPCW)method2009

    • Author(s)
      服部聡
    • Journal Title

      Statistics and Probability Letters 79

      Pages: 1833-1838

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生存時間解析におけるセミパラメトリック推測とその周辺2009

    • Author(s)
      服部聡
    • Journal Title

      統計数理 57

      Pages: 119-138

    • NAID

      120006018981

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient regularization parameter selection via information criteria、Communications in Statistics

    • Author(s)
      Araki Y and Hattori S
    • Journal Title

      Simulation and Computation

      Volume: (印刷中)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of treatment effects based on possibly misspecified Cox regression

    • Author(s)
      Satoshi Hattori
    • Journal Title

      Lifetime Data Analysis

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient regularization parameter selection via information criteria

    • Author(s)
      Yuko Araki
    • Journal Title

      Communications in Statistics, Simulation and Computation

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Meta-analysis of prognostic studies of a biomarker with a study-specific cut-off value2012

    • Author(s)
      貞嶋栄二, 服部聡, 高橋邦彦
    • Organizer
      EAR-BC2012
    • Place of Presentation
      Seoul National University
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 中間解析後の推測2011

    • Author(s)
      服部聡
    • Organizer
      計量生物セミナー
    • Place of Presentation
      キャンパスプラザ京都
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 適用事例から見た最近の話題2011

    • Author(s)
      服部聡
    • Organizer
      計量生物セミナー
    • Place of Presentation
      キャンパスプラザ京都
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 共変量調整ログランク検定の選択について2011

    • Author(s)
      服部聡, 逸見昌之
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      九州大学
    • Year and Date
      2011-09-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 誤特定したCox回帰による統計的推測、科研費シンポジウム2011

    • Author(s)
      服部聡, 逸見昌之
    • Organizer
      医薬品の開発研究における統計的課題と挑戦
    • Place of Presentation
      大阪大学中之島センター
    • Year and Date
      2011-01-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 誤特定したCox回帰による統計的推測2011

    • Author(s)
      服部聡
    • Organizer
      科研費シンポジウム「医薬品の開発研究における統計的課題と挑戦」
    • Place of Presentation
      大阪大学中之島センター
    • Year and Date
      2011-01-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Estimation of treatment effect based on possibly misspecified Cox regression.2010

    • Author(s)
      Satoshi Hattori
    • Organizer
      International Biometric Conference
    • Place of Presentation
      Florianopolis-SC, Brazil.
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 誤特定したCox回帰による治療効果の推定2010

    • Author(s)
      服部聡, 逸見昌之
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2010-09-07
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Analysis of stratified contingency tables via information criteria2010

    • Author(s)
      Hattori S
    • Organizer
      EAR-BC2010
    • Place of Presentation
      Manipal university, Manipal, India
    • Year and Date
      2010-02-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of stratified contingency tables via information criteria2010

    • Author(s)
      Satoshi Hattori
    • Organizer
      EAR-BC2010
    • Place of Presentation
      Manipal university
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Estimation of treatment effect based on possibly misspecified Cox regression2010

    • Author(s)
      Hattori S, Henmi M
    • Organizer
      International Biometric Conference
    • Place of Presentation
      Florianopolis-SC、Brazil
    • Related Report
      2011 Final Research Report
  • [Presentation] 情報量規準に基づく効率的な正則化パラメータ選択2009

    • Author(s)
      荒木由布子, 服部聡
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      同志社大学大学
    • Year and Date
      2009-09-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparing randomized groups based on accelerated failure time model2009

    • Author(s)
      Hattori S
    • Organizer
      The 1^<st> IMS Asia Pacific Rim Meeting
    • Place of Presentation
      National Seoul University
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Efficient regularization parameter selection based on information criteria2009

    • Author(s)
      Araki Y, Hattori S
    • Organizer
      The 1^<st> IMS Asia Pacific Rim Meeting
    • Place of Presentation
      National Seoul University
    • Related Report
      2011 Final Research Report
  • [Presentation] 情報量規準に基づく効率的な正則化パラメータ選択2009

    • Author(s)
      荒木由布子, 服部聡
    • Organizer
      日本計算機統計学会第23回シンポジウム
    • Place of Presentation
      札幌学院大学
    • Related Report
      2011 Final Research Report
  • [Book] ゲノム創薬のためのバイオ統計(バイオ統計学シリーズ62010

    • Author(s)
      館田英典、服部聡
    • Publisher
      近代科学社
    • Related Report
      2011 Final Research Report
  • [Book] ゲノム創薬のためのバイオ統計(バイオ統計学シリーズ6)2010

    • Author(s)
      館田英典, 服部聡
    • Total Pages
      205
    • Publisher
      近代科学社
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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