| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
Olfactory sensory neurons in Drosophila melanogaster are diversified into 50 different classes, each expressing specific odorant receptors, and together contributing to detection and discrimination of a myriad of odorous chemicals in environment. To reveal the developmental mechanisms that generate this neuronal diversity, I analyzed the function of two molecules ; Runx-family transcription factor Lozenge and Drosophila homologue of Evi1 proto-oncogene Hamlet. I found that the precursor cells for the olfactory sensory neurons differentiate continuously while Lozenge level gradually decreases during development. This makes precursor cells that are differentiated at different time points receive different levels of Lozenge, thereby generating different classes of olfactory sensory neurons. I also found that Hamlet contributes to the process of a single precursor cell generating different classes of olfactory sensory neurons, by modifying the expression of the Notch-target genes through epigenetic mechanisms.
|
