Subtype specification of the olfactory sensory neurons in Drosophila by RUNX family transcription factor Lozenge
| Project/Area Number |
21500302
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ENDO Keita 東京大学, 分子細胞生物学研究所, 助教 (40425616)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経クラス分化 / 嗅覚神経細胞 / Runx / Notch / エピジェネティック / 細胞運命決定 / Notchシグナル / Hamlet / クロマチン / 非対称分裂 / エピジェネティックス / Lozenge / 神経前駆細胞 / 経時的な発現量の変化 / ショウジョウバエ / 嗅覚 / 神経サブタイプ分化 / RUNX / EGFR |
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| Research Abstract |
Olfactory sensory neurons in Drosophila melanogaster are diversified into 50 different classes, each expressing specific odorant receptors, and together contributing to detection and discrimination of a myriad of odorous chemicals in environment. To reveal the developmental mechanisms that generate this neuronal diversity, I analyzed the function of two molecules ; Runx-family transcription factor Lozenge and Drosophila homologue of Evi1 proto-oncogene Hamlet. I found that the precursor cells for the olfactory sensory neurons differentiate continuously while Lozenge level gradually decreases during development. This makes precursor cells that are differentiated at different time points receive different levels of Lozenge, thereby generating different classes of olfactory sensory neurons. I also found that Hamlet contributes to the process of a single precursor cell generating different classes of olfactory sensory neurons, by modifying the expression of the Notch-target genes through epigenetic mechanisms.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Chromatin modification of Notch targets in olfactory receptor neuron diversification2012
Author(s)
Endo, K., Karim, M.R., Taniguchi, H., Krejci, A., Kinameri, E., Siebert, M., Ito, K., Bray, S.J., Moore, A.W.
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Journal Title
Nat Neurosci
Volume: 15
Issue: 2
Pages: 224-233
DOI
Related Report
Peer Reviewed
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