Analysis of the growth factor-mediated affective behavior and the correlation with adult neurogenesis.

• Project/Area Number: 21500306
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Kyushu University
• Principal Investigator: UDO Hiroshi 九州大学, 大学院・理学研究院, 助教 (70363322)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: マウス / 脳 / 成長因子 / 神経新生 / 情動 / うつ / 気分障害

Research Abstract

We have characterized the effect of growth factors on affective behaviors and adult neurogenesis using mouse models. We showed that VEGF has antidepressant-and anxiolytic-like effects as well as the ability to enhance adult neurogenesis, which were found to involve monoaminergic modulation. In contrast, although bFGF tended to enhance memory, it did not influence affective behaviors as well as the level of adult neurogenesis.

Research Products

• [Journal Article] Rapid increase in clusters of synaptophysin at onset of homosynaptic potentiation in Aplysia (2011)
  • Author(s): Jin I, Udo H, Hawkins RD.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Pages: 11656-61
  • Peer Reviewed
• [Journal Article] Rapid increase in clusters of synaptophysin at onset of homosynaptic potentiation in Aplysia (2011)
  • Author(s): Jin I, Udo H, Hawkins RD
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Issue: 28 Pages: 11656-61
  • DOI: 10.1073/pnas.1102695108
  • Peer Reviewed
• [Journal Article] Rapid and long-lasting increase in sites for synapse assembly during late-phase potentiation in rat hippocampal neurons (2009)
  • Author(s): Antonova I, Lu FM, Zablow L, Udo H, Hawkins RD.
  • Journal Title: PLoS One Volume: 4 Pages: 7690-7690
  • Peer Reviewed
• [Journal Article] Rapid and long-lasting increase in sites for synapse assembly during late-phase potentiation in rat hippocampal neurons (2009)
  • Author(s): Antonova, et al.
  • Journal Title: PLoS One 4
  • Peer Reviewed
• [Presentation] A potential role of vascular endothelial growth factor in modulation of serotonergic and noradrenergic systems for antidepressant-and anxiolytic-like behaviors. (2010)
  • Author(s): Udo H, Yoshida Y, Ohnuki K, Sugiyama H.
  • Organizer: Neuroscience
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2010-11-16
• [Presentation] A potential role of vascular endothelial growth factor in modulation of serotonergic and noradrenergic systems for antidepressant- and anxiolytic-like behaviors (2010)
  • Author(s): 有働洋
  • Organizer: 神経科学会(Society for Neuroscience)
  • Place of Presentation: 米国カルフォルニア州サンディエゴ
  • Year and Date: 2010-11-16
• [Presentation] Altered affective behavior in mice overexpressing vascular endothelial growth factor 120 (2009)
  • Author(s): Udo H, Hamasu K, Furuse M, Ohnuki K, Sugiyama H.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] Altered affective behavior in mice overexpressing vascular endothelial growth factor 120 (2009)
  • Author(s): 有働洋
  • Organizer: 日本神経科学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-18
• [Patent(Industrial Property Rights)] 神経細胞分化促進剤 (2009)
  • Inventor(s): 松川、有働、他
  • Industrial Property Rights Holder: ユーハ味覚糖
  • Industrial Property Number: 2009-272229
  • Filing Date: 2009-11-30
  • Overseas
• [Patent(Industrial Property Rights)] 神経細胞分化促進剤 (2009)
  • Inventor(s): 松川, 他
  • Industrial Property Rights Holder: ユーハ味覚糖
  • Industrial Property Number: 2009-272229
  • Filing Date: 2009-11-30