Research of repetitive TMS mechanisms for therapy of neurological disease using near infrared spectroscopy and electrophysiological metho ds
| Project/Area Number |
21500308
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UGAWA Yoshikazu 福島県立医科大学, 医学部, 神経内科 (50168671)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 非侵襲的脳活動計測 / 近赤外線トポグラフィー / 磁気刺激法 / 脳血流 / 体性感覚誘発電位 |
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| Research Abstract |
The more efficient stimulation parameter of the repetitive TMS method was determined. The effect of stimuli is facilitatory when the stimulus interval of quadripulse stimulation(QPS) is 5 ms(QPS-5ms), and that is inhibitory when a stimulus interval is 50 ms(QPS-50ms). Moreover, we developed the probe holder of the near infrared spectroscopy(NIRS) suited to a brand-new ultralight magnetic stimulation coil, and enabled measurement of multi-channel NIRS directly under a site of the stimulus for the first time in the world. Using these systems, the online effect under magnetic stimulation was measured at the left primary motor cortex using the 2-minute QPS-5ms or QPS-50ms, and we indicated that these online-effects of QPSs were different from the long-after-effect of those.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Some evidence supporting the safety of quadripulse stimulation2011
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Mochizuki H, Kobayashi S, Enomoto H, Sugiura Y, Matsumoto H, Furubayashi T, Terao Y, Sato F, Ugawa Y
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Journal Title
Brain Stimul
Volume: 4
Pages: 303-305
Related Report
Peer Reviewed
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