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Research of repetitive TMS mechanisms for therapy of neurological disease using near infrared spectroscopy and electrophysiological metho ds

Research Project

Project/Area Number 21500308
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionFukushima Medical University

Principal Investigator

MOCHIZUKI Hitoshi  福島県立医科大学, 医学部, 講師 (50501699)

Co-Investigator(Renkei-kenkyūsha) UGAWA Yoshikazu  福島県立医科大学, 医学部, 神経内科 (50168671)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords非侵襲的脳活動計測 / 近赤外線トポグラフィー / 磁気刺激法 / 脳血流 / 体性感覚誘発電位
Research Abstract

The more efficient stimulation parameter of the repetitive TMS method was determined. The effect of stimuli is facilitatory when the stimulus interval of quadripulse stimulation(QPS) is 5 ms(QPS-5ms), and that is inhibitory when a stimulus interval is 50 ms(QPS-50ms). Moreover, we developed the probe holder of the near infrared spectroscopy(NIRS) suited to a brand-new ultralight magnetic stimulation coil, and enabled measurement of multi-channel NIRS directly under a site of the stimulus for the first time in the world. Using these systems, the online effect under magnetic stimulation was measured at the left primary motor cortex using the 2-minute QPS-5ms or QPS-50ms, and we indicated that these online-effects of QPSs were different from the long-after-effect of those.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (9 results) Book (1 results)

  • [Journal Article] Quadri-pulse stimulation induces stimulation frequency dependent cortical hemoglobin concentration changes within the ipsilateral motor cortical network2012

    • Author(s)
      Groiss SJ, Mochizuki H, Furubayashi T, Kobayashi S, Nakatani-Enomoto S, Nakamura K, Ugawa Y
    • Journal Title

      Brain Stimul

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ataxic hemiparesis : neurophysiological analysis by cerebellar transcranial magnetic stimulation2011

    • Author(s)
      Kikuchi S, Mochizuki H, et al
    • Journal Title

      Cerebellum

      Volume: (In press) Issue: 1 Pages: 259-263

    • DOI

      10.1007/s12311-011-0303-0

    • Year and Date
      2011-07-29
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On-line effects of quadripulse transcranial magnetic stimulation(QPS) on the contralateral hemisphere studied with somatosensory evoked potentials and near infrared spectroscopy2011

    • Author(s)
      Hirose M, Mochizuki H, Groiss SJ, Tanji Y, Nakamura K, Nakatani-Enomoto S, Enomoto H, Nishizawa M, Ugawa Y
    • Journal Title

      Exp Brain Res

      Volume: 214 Pages: 577-586

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Some evidence supporting the safety of quadripulse stimulation2011

    • Author(s)
      Nakatani-Enomoto S, Hanajima R, Hamada M, Mochizuki H, Kobayashi S, Enomoto H, Sugiura Y, Matsumoto H, Furubayashi T, Terao Y, Sato F, Ugawa Y
    • Journal Title

      Brain Stimul

      Volume: 4 Pages: 303-305

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 磁気刺激の臨床応用2011

    • Author(s)
      望月仁志、宇川義一
    • Journal Title

      神経内科領域

      Volume: 39巻 Pages: 965-969

    • Related Report
      2011 Final Research Report
  • [Journal Article] 治療としての反復磁気刺激Parkinson病への応用と新しい刺激法2011

    • Author(s)
      望月仁志、宇川義一
    • Journal Title

      神経治療学

      Pages: 354-355

    • Related Report
      2011 Final Research Report
  • [Journal Article] On-line effects of quadripulse transcranial magnetic stimulation (QPS) on the contralateral hemisphere studied with somatosensory evoked patentials and near infrared spectroscopy2011

    • Author(s)
      Hirose M, Mochizuki H, et al
    • Journal Title

      Exp Brain Res

      Volume: 214 Issue: 4 Pages: 577-586

    • DOI

      10.1007/s00221-011-2855-0

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Some evidence supporting the safety of quadripulse stimulation (QPS)2011

    • Author(s)
      Nakatani-enomoto S, et al
    • Journal Title

      Brain Stimulation

      Volume: 4 Pages: 303-305

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apraxia of lid opening due to a small lesion in basal ganglia ; two case reports2010

    • Author(s)
      Hirose M, Mochizuki H, et al
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 81 Pages: 1406-1407

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 各種神経疾患におけるsomatosensory evoked high-frequency oscillation (HFOs)臨床の現場で役立つHFOの知識2010

    • Author(s)
      望月仁志, 宇川義一
    • Journal Title

      臨床脳波

      Volume: 52 Pages: 459-465

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Brain volume analyses and somatosensory evoked potentials in multiple system at rophy2009

    • Author(s)
      Miyatake S, Mochizuki H, et al
    • Journal Title

      Journal of Neurology 257

      Pages: 419-425

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micturitional disturbance due to bilateral medial frontal lobe lesions in a patient with multiple sclerosis2009

    • Author(s)
      Namatame S, Mochizuki H, et al
    • Journal Title

      Neurological Sciences 31

      Pages: 205-207

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bidirectional modulation of sensory cortical excitability by quadripulse trans cranial magnetic stimulation (QPS) in humans

    • Author(s)
      Nakatani-enomoto S, et al
    • Journal Title

      Clin Neurophysiology

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quadri-pulse stimulation induces stimulation frequency dependent cortical hemoglobin concentration changes within the ipsilateral motor cortical network

    • Author(s)
      Groiss SJ, Mochizuki H, et al
    • Journal Title

      Brain stimulation

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 運動野に対するQuadri-pulse stimulationが、対側感覚野に与える影響について2011

    • Author(s)
      望月仁志, ら
    • Organizer
      第41回日本臨床神経生理学会
    • Place of Presentation
      静岡
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Near-infrared spectroscopy (NIRS) responses to a large click sound2011

    • Author(s)
      Mochizuki H, et al
    • Organizer
      14^<th> European congress on clinical neurophysiology
    • Place of Presentation
      Roma
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Large click sounds influence near infrared spectroscopy2011

    • Author(s)
      Mochizuki H., Hirose M., Nakamura K., Nakatani-Enomoto S., Enomoto H., Ugawa Y
    • Organizer
      14th European congress of clinical neurophysiology and the 4^<th> international conference on transcranial magnetic and direct current stimulation
    • Place of Presentation
      Rome, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Transcranial magnetic stimulation and near infrared spectroscopy2010

    • Author(s)
      Mochizuki H, Ugawa Y
    • Organizer
      29^<th> International Congress of Clinical Neurophysiology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当科における筋委縮性側索硬化症の初期診断確定までの経過について2010

    • Author(s)
      望月仁志, ら
    • Organizer
      日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transcranial magnetic stimulation and near infrared spectroscopy2010

    • Author(s)
      Mochizuki H, Ugawa Y
    • Organizer
      29^<th> International Congress of Clinical Neurophysiology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] 大脳感覚野・運動野の内因性リズムの意味 高周波振動(HFOs)に関連して 各種神経疾患におけるsomatosensory evoked high-frequency oscillations (HFOs)2009

    • Author(s)
      望月仁志, 宇川義一
    • Organizer
      臨床神経生理学会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] クリック音の近赤外線スペクトロスコピー(NIRS)計測への影響2009

    • Author(s)
      廣瀬正樹、望月仁志, ら
    • Organizer
      臨床神経生理学会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 近赤外線スペクトロスコピー Near-infrared spectroscopy (NIRS)2009

    • Author(s)
      望月仁志
    • Organizer
      臨床神経生理学会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Book] 今日の診断指針2010

    • Author(s)
      望月仁志
    • Publisher
      医学書院出版
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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