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Mechanisms of speech sound discrimination learning in the rat auditory and association cortices

Research Project

Project/Area Number 21500309
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionTeikyo University

Principal Investigator

KUDOH Masaharu  帝京大学, 医学部, 教授 (80153310)

Research Collaborator OGAWA Go  帝京大学, 大学院生
NISHIDA Yoko  東都医療大学, ヒューマンケア学部, 講師
HIGASHIDE Keishi  芝浦工業大学, 大学院・理工学研究科, 修士課程
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords母音 / ホルマント / 摩擦子音 / 弁別学習 / 機能的結合 / 一次聴覚野 / 前聴覚野 / ラット / 言語音 / 聴覚野 / 連合野
Research Abstract

Flavoprotein autofluorescence imaging showed that synthetic formants and vowels evoked prominent responses in the anterior(AAF) and dorsal(DAF) auditory field in addition to the primary auditory cortex(AI), while fricative consonants evoked responses in the AI, DAF and ventral auditory field(VAF). Electrical stimulation to AAF elicited fluorescence responses in DAF while that to AI evoked responses in DAF and VAF. AAF responded markedly to formants with fast change of waveform envelopes, while AI responses depended on spectrum of sounds. These findings suggest that there are dual pathways for speech sound discrimination.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2012 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (28 results)

  • [Journal Article] Transcranial electrical stimulation of cortico-cortical connections in anesthetized mice2011

    • Author(s)
      Hishida R, Watanabe K, Kudoh M, Shibuki K
    • Journal Title

      J Neurosci Methods

      Volume: 201 Pages: 315-321

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 音系列の弁別学習と聴覚野のドーパミンD2受容体2009

    • Author(s)
      工藤雅治
    • Journal Title

      生体の科学

      Volume: 60 Pages: 416-417

    • Related Report
      2011 Final Research Report
  • [Journal Article] 音系列の弁別学習と聴覚野のドーパミンD2受容体2009

    • Author(s)
      工藤雅治
    • Journal Title

      生体の科学 60

      Pages: 416-417

    • Related Report
      2009 Annual Research Report
  • [Presentation] Discrimination pathways of synthetic fricative consonants in the rat auditory cortex2012

    • Author(s)
      Higashide K, Kobayashi T, Kudoh M
    • Organizer
      日本生理学会大会
    • Place of Presentation
      松本文化会館(松本市)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 言語音弁別学習におけるラット聴覚領野の並列・直列的な機能分担2011

    • Author(s)
      工藤雅治, 小川剛, 西田陽子, 東出圭司
    • Organizer
      日本音響学会聴覚研究会
    • Place of Presentation
      豊橋
    • Year and Date
      2011-11-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Zic2 knock down mice show the higher response to auditory stimulus and size reduction of DCoN2011

    • Author(s)
      Matsumoto Y, Takashima N, Nozaki Y, Nishioka C, Kudoh M, Aruga J
    • Organizer
      Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Washington, DC
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 仔ラットの音声に対する母ラット聴覚野の増強した反応2011

    • Author(s)
      西田陽子, 工藤雅治
    • Organizer
      日本母性衛生学会学術集会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Auditory cortical responses to harmonic type and noise type pup calls in mother rats2011

    • Author(s)
      Nishida Y, Kudoh M
    • Organizer
      日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Neuronal responses to synthetic fricative consonants in the rat auditory fields2011

    • Author(s)
      Higashide K, T, Kudoh M
    • Organizer
      日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Dorsal auditory field receives convergent inputs from the anterior auditory field and primary auditory cortex in rats2011

    • Author(s)
      Ogawa G, Kudoh M
    • Organizer
      日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Zic2 plays an essential role in the formation of auditory neural circuit2011

    • Author(s)
      Aruga J, Matsumoto, Takashima N, Kudoh M
    • Organizer
      日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Auditory and Vestibular Impairment of Slitrk6-Deficient Mice2011

    • Author(s)
      Matsumoto Y, Katayama K, Okamoto T, Yamada K, Nagao S, Kudoh M
    • Organizer
      日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 摩擦子音に対するラット大脳聴覚野活動のイメージング2011

    • Author(s)
      東出圭司, 小林孝和, 工藤雅治
    • Organizer
      日本生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Dual pathways for sound discrimination in the rat auditory cortex2010

    • Author(s)
      Masaharu Kudoh, Go Ogawa, Yoko Nishida
    • Organizer
      40th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dual pathways for sound discrimination in the rat auditory cortex2010

    • Author(s)
      Kudoh M, Ogawa G, Nishida Y
    • Organizer
      Tucker-Davis Symposium on Advances and Perspectives in Auditory Neurophysiology(APAN VIII)
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Dual pathways for sound discrimination in the rat auditory cortex2010

    • Author(s)
      Masaharu Kudoh, Go Ogawa, Yoko Nishida
    • Organizer
      Tucker-Davis Symposium on Advances and Perspectives in Audlitory Neurophysiology (APAN VIII)
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Two parallel pathways for sound discrimination in the rat auditory cortex2010

    • Author(s)
      Go Ogawa, Masaharu Kudoh
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Auditory cortical responses to pup calls in mother rats2010

    • Author(s)
      Yoko Nishida, Junzo Kato, Masaharu Kudoh
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット聴覚野の並列情報処理経路:前聴覚野経路と一次聴覚野経路2010

    • Author(s)
      工藤雅治, 小川剛, 西田陽子, 東出圭司
    • Organizer
      日本音響学会聴覚研究会
    • Place of Presentation
      豊橋
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Dual pathways for sound discrimination in the rat auditory cortex2010

    • Author(s)
      Kudoh M, Ogawa G, Nishida Y
    • Organizer
      40^<th> Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒトの母子音声コミュニケーションについてのラットモデルによる研究2010

    • Author(s)
      西田陽子、加藤順三、久米美代子、工藤雅治
    • Organizer
      第51回母性衛生学会総会
    • Place of Presentation
      金沢
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Auditory cortical responses to pup calls in mother rats2010

    • Author(s)
      Nishida Y, Kato J, Kudoh M
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Two parallel pathways for sound discrimination in the rat auditory cortex2010

    • Author(s)
      Ogawa G, Kudoh M
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Plastic changes in the anterior and dorsal auditory fields induced by discrimination learning of synthetic vowels in rats2009

    • Author(s)
      Kudoh M, Ogawa G
    • Organizer
      39^<th> Annual Meeting of Society of Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2009-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Plastic changes in the anterior and dorsal auditory fields inducedby discrimination learning of synthetic vowels in rats2009

    • Author(s)
      工藤雅治、小川剛
    • Organizer
      北米神経科学学会
    • Place of Presentation
      Chicago
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Plastic changes in the anterior and dorsal auditory fields induced by discrimination learning of synthetic vowels in rats2009

    • Author(s)
      Kudoh M, Ogawa G
    • Organizer
      Tucker-Davis Symposium on Advances and Perspectives in Auditory Neurophysiology(APAN VII)
    • Place of Presentation
      Chicago
    • Year and Date
      2009-10-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Plastic changes in the auditory fields induced by discrimination learning of synthetic vowels in rats2009

    • Author(s)
      Kudoh M, Ogawa G
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Plastic changes in the anterior and dorsal auditory fields induced by discrimination learning of synthetic vowels in rats2009

    • Author(s)
      工藤雅治、小川剛
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Plastic changes in the anterior auditory fields induced by discrimination learning of synthetic vowels in rats2009

    • Author(s)
      Kudoh M
    • Organizer
      第36回国際生理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-07-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Plastic changes in the anterior auditory fields induced by discrimination learning of synthetic vowels in rats2009

    • Author(s)
      工藤雅治
    • Organizer
      第36会国際生理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 合成言語音弁別学習に関わるラット聴覚野活動2009

    • Author(s)
      工藤雅治、小川剛、西田陽子
    • Organizer
      日本音響学会聴覚研究会
    • Place of Presentation
      豊橋
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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