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The mechanisms for generation of rhythmic activities in the interneuronal networks

Research Project

Project/Area Number 21500317
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionTamagawa University

Principal Investigator

TSUKAMOTO Yoko (FUJIWARA yoko)  玉川大学, 脳科学研究所, 嘱託研究員 (90209130)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords海馬 / リズム / 介在細胞 / 神経回路 / 生理学 / 脳・神経 / GABA / ギャップ結合 / 大脳皮質 / 神経科学
Research Abstract

The aim of our research is to elucidate the mechanisms for generation of rhythmic activities in the brain, such as EEG and epilepsy. In this study, we analyzed rhythmic neuronal synchronization induced by strong electrical stimulation in acute slice preparations of rat hippocampus and cerebral cortices, using whole-cell patch-clamp technique. We found that a network of fast-spiking interneurons alone can drive the electrically induced rhythmic activity(prototypic afterdischarge) in the hippocampal CA1 area, entorhinal cortex and neocortex.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) Remarks (2 results)

  • [Journal Article] Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons2010

    • Author(s)
      Fujiwara-Tsukamoto, Y., Isomura, Y., Imanishi, M., Ninomiya, T., Tsukada, M., Yanagawa, Y., Fukai, T., Takada, M.
    • Journal Title

      J. Neurosci

      Volume: 30(41) Pages: 13679-89

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prototypic seizure activity driven by mature hippoccampal fast-spiking interneurons2010

    • Author(s)
      Fujiwara-Tsukamoto Y
    • Journal Title

      The Journal of Neuroscience

      Volume: 30 Pages: 13679-13689

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラット海馬/大脳皮質におけるprototypic afterdischarge発現の領域特異性2011

    • Author(s)
      塚元葉子、礒村宜和、今西美知子、塚田稔、高田昌彦
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット海馬/大脳皮質におけるprototypic afterdischargen発現の領域特異性2011

    • Author(s)
      塚元葉子
    • Organizer
      Neuro2011(第34回日本神経科学大会)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海馬/大脳皮質各領域における後発射前駆活2010

    • Author(s)
      塚元葉子、礒村宜和、今西美知子、塚田稔、高田昌彦
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Different patterns of precursory afterdischarge generated in hippocampal/cortical subareas2010

    • Author(s)
      Fujiwara-Tsukamoto Y
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] グルタミン酸非依存性海「proto-afterdischarge」の発生に関与する海馬インターニューロンサブタイプの同定2009

    • Author(s)
      塚元葉子、礒村宜和、今西美知子、二宮太平、柳川右千夫、深井朋樹、高田昌彦
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of interneuron subtypes driving glutamate-independent "proto-afterdischarge" in rat hippocampal slices2009

    • Author(s)
      Fujiwara-Tsukamoto Y
    • Organizer
      第32回日本神経科学学会大会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of interneuron subtypes participating in glutamate-independent network oscillations in rat hippocampal slices2009

    • Author(s)
      Fujiwara-Tsukamoto Y
    • Organizer
      第36回国際生理学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tamagawa.ac.jp/teachers/isomura/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.tamagawa.ac.jp/teachers/isomura/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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