The mechanisms for generation of rhythmic activities in the interneuronal networks

• Project/Area Number: 21500317
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Tamagawa University
• Principal Investigator: TSUKAMOTO Yoko (FUJIWARA yoko) 玉川大学, 脳科学研究所, 嘱託研究員 (90209130)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 海馬 / リズム / 介在細胞 / 神経回路 / 生理学 / 脳・神経 / GABA / ギャップ結合 / 大脳皮質 / 神経科学

Research Abstract

The aim of our research is to elucidate the mechanisms for generation of rhythmic activities in the brain, such as EEG and epilepsy. In this study, we analyzed rhythmic neuronal synchronization induced by strong electrical stimulation in acute slice preparations of rat hippocampus and cerebral cortices, using whole-cell patch-clamp technique. We found that a network of fast-spiking interneurons alone can drive the electrically induced rhythmic activity(prototypic afterdischarge) in the hippocampal CA1 area, entorhinal cortex and neocortex.

Research Products

• [Journal Article] Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons (2010)
  • Author(s): Fujiwara-Tsukamoto, Y., Isomura, Y., Imanishi, M., Ninomiya, T., Tsukada, M., Yanagawa, Y., Fukai, T., Takada, M.
  • Journal Title: J. Neurosci Volume: 30(41) Pages: 13679-89
  • Peer Reviewed
• [Journal Article] Prototypic seizure activity driven by mature hippoccampal fast-spiking interneurons (2010)
  • Author(s): Fujiwara-Tsukamoto Y
  • Journal Title: The Journal of Neuroscience Volume: 30 Pages: 13679-13689
  • Peer Reviewed
• [Presentation] ラット海馬/大脳皮質におけるprototypic afterdischarge発現の領域特異性 (2011)
  • Author(s): 塚元葉子、礒村宜和、今西美知子、塚田稔、高田昌彦
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] ラット海馬/大脳皮質におけるprototypic afterdischargen発現の領域特異性 (2011)
  • Author(s): 塚元葉子
  • Organizer: Neuro2011(第34回日本神経科学大会)
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] 海馬/大脳皮質各領域における後発射前駆活 (2010)
  • Author(s): 塚元葉子、礒村宜和、今西美知子、塚田稔、高田昌彦
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Different patterns of precursory afterdischarge generated in hippocampal/cortical subareas (2010)
  • Author(s): Fujiwara-Tsukamoto Y
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-09-03
• [Presentation] グルタミン酸非依存性海「proto-afterdischarge」の発生に関与する海馬インターニューロンサブタイプの同定 (2009)
  • Author(s): 塚元葉子、礒村宜和、今西美知子、二宮太平、柳川右千夫、深井朋樹、高田昌彦
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Identification of interneuron subtypes driving glutamate-independent "proto-afterdischarge" in rat hippocampal slices (2009)
  • Author(s): Fujiwara-Tsukamoto Y
  • Organizer: 第32回日本神経科学学会大会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-09-17
• [Presentation] Identification of interneuron subtypes participating in glutamate-independent network oscillations in rat hippocampal slices (2009)
  • Author(s): Fujiwara-Tsukamoto Y
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-07-28
• [Remarks]
  • URL: http://www.tamagawa.ac.jp/teachers/isomura/index.html
• [Remarks]
  • URL: http://www.tamagawa.ac.jp/teachers/isomura/index.html