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Effects of proteases on differentiation and maturation of oligodendrocytes

Research Project

Project/Area Number 21500322
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionAsahikawa Medical College

Principal Investigator

YOSHIDA Shigetaka  旭川医科大学, 医学部, 教授 (20230740)

Co-Investigator(Kenkyū-buntansha) BANDO Yoshio  旭川医科大学, 医学部, 講師 (20344575)
MURAKAMI Koichi  旭川医科大学, 医学部, 助教 (90400085)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsオリゴデンドロサイト / プロテアーゼ / KLK6 / 発達 / ミエリン / 脱髄
Research Abstract

KLK6 is a serine protease specifically expressed in oligodendrocytes. The function of the protease on the maturation of oligodendrocyte has been undetermined. We analyzed KLK6 gene knockout (KLK6-KO) mice and found that the development of oligodendrocytes was temporally delayed. We also found that the expression of myelin basic protein was smaller in KLK6-KO mice than that of wild-type mice. These results indicate that KLK6 plays a role in the development of oligodendrocytes.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (7 results)

  • [Journal Article] Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR22012

    • Author(s)
      Kishibe M, Bando Y, Tanaka T, Ishida-Yamamoto A, Iizuka H, Yoshida S
    • Journal Title

      J Invest Dermatol

      Volume: (印刷中) Issue: 6 Pages: 1717-1724

    • DOI

      10.1038/jid.2012.18

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Klk8, a Multifunctional Protease in the Brain and Skin : Analysis of Knockout Mice2010

    • Author(s)
      Yoshida S
    • Journal Title

      Biol Chem

      Volume: 391 Pages: 375-380

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] オリゴデンドロサイトの生死とプロテアーゼ2010

    • Author(s)
      吉田成孝
    • Journal Title

      脳21

      Volume: 13 Pages: 9-14

    • Related Report
      2011 Final Research Report
  • [Journal Article] オリゴデンドロサイトの生死とプロテアーゼ2010

    • Author(s)
      吉田成孝
    • Journal Title

      脳21 13

      Pages: 9-14

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Klk8, a Multifunctional Protease in the Brain and Skin : Analysis of Knockout Mice.2010

    • Author(s)
      Yoshida S
    • Journal Title

      Biol.Chem. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 実験的自己免疫性脳脊髄炎モデルを用いた脱髄の形態学的解析2011

    • Author(s)
      野村太一、板東良雄、暮地本宙己、渡部剛、吉田成孝
    • Organizer
      日本解剖学会第57回東北・北海道連合支部学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2011-09-11
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] The delay of oligodendrocyte development and myelination in KLK6 deficient mouse2011

    • Author(s)
      Murakami K, Jiang Y-P, TanakaT, Bando Y, Yoshida S
    • Organizer
      4th International Symposium on Kallikrein-Related Peptidases (ISK2011)
    • Place of Presentation
      Rhodes Island、Greece
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Morphological changes of axons and myelin in experimental autoimmune encephalomyelitis2011

    • Author(s)
      BandoY, Nomura T, Bochimoto H, Kouga D, Watanabe T, Yoshida S
    • Organizer
      10th Biennial ISN Satellite Meeting on Myelin Biology
    • Place of Presentation
      Kolymvari, Crete, Greece
    • Year and Date
      2011-08-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] KLK6ノックアウトマウスにおけるミエリン関連タンパクの発現変動2010

    • Author(s)
      村上公一、板東良雄、吉田成孝
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス多発性硬化症モデルにおけるKLK6を介した脱髄分子機所2010

    • Author(s)
      板東良雄、村上公一、吉田成孝
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] KLK6ノックアウトマウスにおけるオリゴデンドロサイト関連マーカーの発現2009

    • Author(s)
      村上公一, 板東良雄, 吉田成孝
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] KLK8, a Multifunctional Protease in the Brain and Skin : Analysis of Knockout Mice2009

    • Author(s)
      Yoshida S, Shiosaka S
    • Organizer
      3rd International Symposium on Kallikreins and Kallikrein-related Peptidases
    • Place of Presentation
      ミュンヘン
    • Year and Date
      2009-09-01
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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