Morphological analysis of the visceral sensory pathways to the leptin-melanocortin system in the feeding. related neural circuits of the hypothalamus
| Project/Area Number |
21500325
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUMORI Toshiko 島根大学, 医学部, 准教授 (30217377)
YOKOTA Shigefumi 島根大学, 医学部, 助教 (50294369)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 視床下部 / 結合腕傍核 / 扁桃体 / オレキシン / メラニン凝集ホルモン神経回路 / 摂食行動 / メラニン凝集ホルモン / 神経回路 / グルタミン酸 / ラット / 島皮質 / シナプス |
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| Research Abstract |
We examined the visceral sensory pathways to the leptin-melanocortin system in the rat hypothalamus. The results of the present study are as follows :(1) orexin neurons are under the excitatory influence of the glutamatergic neurons of the lateral parabrachial nucleus which is the relay site of visceral sensory information ;(2) melanin-concentrating hormone neurons are under the excitatory influence of the glutamatergic neurons of the cortical and basomedial nuclei which are involved in processing olfactory and visceral information.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn.2011
Author(s)
R. Aoyama, Y. Okada, S. Yokota, K. Fukuda, Y. Shinozaki, H. Yoshida, M. Nakamura, K. Chiba, Y. Yasui, F. Kato, Y. Toyama
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Journal Title
Pain
Volume: 152
Pages: 2085-2097
Related Report
Peer Reviewed
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