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Research on the structural plasticity and pathogenesis of depressive disorders

Research Project

Project/Area Number 21500328
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyushu University

Principal Investigator

JINNO Shozo  九州大学, 大学院・医学研究院, 教授 (10325524)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords神経回路網 / 構造的可塑性 / ステレオロジー / うつ病 / ミクログリア / アストロサイト / ニューロン・グリア連関 / 海馬 / 舌下神経 / ミノサイクリン / グルタミン酸 / 神経変性 / 加齢 / 認知症 / 神経新生 / グリア / 神経可塑性 / 背側・腹側
Research Abstract

We carried out the neuroscience research on the morphological plasticity of neurons and glial cells constituting neuronal network, and obtained the following outcomes.(1) Adult neurogenesis in the dentate gyrus declined more severely in the ventral hippocampus than in the dorsal hippocampus.(2) Numerical densities of astrocytes increased in the stratum lacunosum-moleculare in the ventral hippocampus but not in the dorsal hippocampus with aging.(3) In the axotomy model, astrocytic, but not microglial, reaction may primarily mediate some anti-apoptotic effects through synaptic stripping.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (38 results)

All 2012 2011 2010 2009 Other

All Journal Article (19 results) (of which Peer Reviewed: 8 results) Presentation (15 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping2012

    • Author(s)
      Jinno S, Yamada J
    • Journal Title

      Neuron Glia Biology

      Volume: 5 Issue: 1 Pages: 1-12

    • DOI

      10.1017/s1740925x11000135

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping2011

    • Author(s)
      Jinno S, Yamada J.
    • Journal Title

      Neuron Glia Biol

      Volume: 504 Pages: 295-300

    • Related Report
      2011 Final Research Report
  • [Journal Article] Alterations in neuronal survival and glial reactions after axotomy by ceftriaxone and minocycline in the mouse hypoglossal nucleus2011

    • Author(s)
      Yamada J, Jinno S.
    • Journal Title

      Neurosci Lett

      Volume: 504 Pages: 295-300

    • Related Report
      2011 Final Research Report
  • [Journal Article] Differential involvement of perineuronal astrocytes and microglia in synaptic stripping after hypoglossal axotomy2011

    • Author(s)
      Yamada J, Nakanishi H, Jinno S.
    • Journal Title

      Neuroscience

      Volume: 182 Pages: 1-10

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Regional and laminar differences in antigen profiles and spatial distributions of astrocytes in the mouse hippocampus, with reference to aging2011

    • Author(s)
      Jinno S.
    • Journal Title

      Neuroscience

      Volume: 180 Pages: 41-52

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Decline in adult neurogenesis during aging follows a topographic pattern in the mouse hippocampus2011

    • Author(s)
      Jinno S.
    • Journal Title

      J Comp Neurol

      Volume: 519 Pages: 451-66

    • Related Report
      2011 Final Research Report
  • [Journal Article] Topographic differences in adult neurogenesis in the mouse hippocampus : a stereology-based study using endogenous markers2011

    • Author(s)
      Jinno S.
    • Journal Title

      Hippocampus

      Volume: 21 Pages: 467-80

    • Related Report
      2011 Final Research Report
  • [Journal Article] Alterations in neuronal survival and glial reactions after axotomy by ceftriaxone and minocycline in the mouse hypoglossal nucleus2011

    • Author(s)
      Yamada J, Jinno S
    • Journal Title

      Neuroscience letters

      Volume: 504 Issue: 3 Pages: 295-300

    • DOI

      10.1016/j.neulet.2011.09.051

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regional and laminar differences in antigen profiles and spatial distributions of a strocytes in the mouse hippocampus, with reference to aging2011

    • Author(s)
      Jinno S
    • Journal Title

      Neuroscience

      Volume: 180 Pages: 41-52

    • DOI

      10.1016/j.neuroscience.2011.02.013

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decline in adult neurogenesis during aging follows a topographic pattern in the mouse hippocampus2011

    • Author(s)
      JINNO S
    • Journal Title

      J Comp Neurol

      Volume: 519 Pages: 451-466

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereological estimation of numerical densities of glutamatergic principal neurons in the mouse hippocampus2010

    • Author(s)
      Jinno S, Kosaka T.
    • Journal Title

      Hippocampus

      Volume: 20 Pages: 829-40

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cortical GABAergic Neurons : Stretching it Remarks, Main Conclusions and Discussion2010

    • Author(s)
      Clancy B, Defelipe J, Espinosa A, Fairen A, Jinno S, Kanold P, Luhmann HJ, Rockland KS, Tamamaki N, Yan XX.
    • Journal Title

      Front Neuroanat

      Volume: 4(7) Pages: 1-18

    • Related Report
      2011 Final Research Report
  • [Journal Article] Topographic differences in adult neurogenesis in the mouse hippocampus : A stereology-based study using endogenous markers2010

    • Author(s)
      Jinno S
    • Journal Title

      Hippocampus (Published online Jan 19, 2010)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cortical GABAergic Neurons : Stretching it Remarks, Main Conclusions and Discussion2010

    • Author(s)
      Clancy B, Defelipe J, Espinosa A, Fairen A, Jinno S, Kanold P, Luhmann HJ, Rockland KS, Tamamaki N, Yan XX
    • Journal Title

      Front Neuroanat 4

      Pages: 1-8

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Neuronal circuit-dependent alterations in expression of two isoforms of glutamic acid decarboxylase in the hippocampus following electroconvulsive shock : A stereology-based study2009

    • Author(s)
      Jinno S, Kosaka T.
    • Journal Title

      Hippocampus

      Volume: 19 Pages: 1130-1141

    • Related Report
      2011 Final Research Report
  • [Journal Article] Structural organization of long-range GABAergic projection system of the hippocampus2009

    • Author(s)
      Jinno S.
    • Journal Title

      Front Neuroanat

      Volume: 3(13) Pages: 1-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Stereological estimation of numerical densities of glutamatergic principal neurons in the mouse hippocampus2009

    • Author(s)
      Jinno S, Kosaka T
    • Journal Title

      Hippocampus (Published online Aug 4, 2009)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural organization of long-range GABAergic projection system of the hippocampus2009

    • Author(s)
      Jinno S
    • Journal Title

      Front Neuroanat 3

      Pages: 1-9

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential involvement of perineuronal astrocytes and microglia in synaptic stripping after hypoglossal axotomy

    • Author(s)
      Yamada J, Nakanishi H, JINNO S
    • Journal Title

      Neuroscience

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ペリニューロナルネットを有するニューロンの神経化学的多様性2012

    • Author(s)
      関善弘,山田純,神野尚三
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] S100A6は活性化アストロサイトと神経幹細胞の選択的マーカーである2012

    • Author(s)
      山田純、神野尚三
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ミクログリア形態の活性化過程の経時変化2011

    • Author(s)
      山田純,神野尚三
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ダイセクター法による海馬神経新生の長軸方向による差異と加齢変化の研究2011

    • Author(s)
      神野尚三
    • Organizer
      日本顕微鏡学会第67回学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      2011-05-16
    • Related Report
      2011 Final Research Report
  • [Presentation] ダイセクター法による海馬神経新生の長軸方向による差異と加齢変化の研究2011

    • Author(s)
      神野尚三
    • Organizer
      日本顕微鏡学会第67回学術講演会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス海馬オリゴデンドロサイトの産生・分化の加齢変化に関するステレオロジー解析2011

    • Author(s)
      神野尚三
    • Organizer
      第116回日本解剖学会全国学術集会
    • Place of Presentation
      東日本大震災のため日本生理学会誌上開催
    • Year and Date
      2011-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス海馬オリゴデンドロサイトの産生・分化の加齢変化に関するステレオロジー解析2011

    • Author(s)
      神野尚三
    • Organizer
      日本解剖学会全国学術集会
    • Place of Presentation
      (東日本大震災のため日本生理学会誌上開催)
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加齢に伴うアストロサイトの空間分布様式の変化には海馬の層・領域による差異が存在する2010

    • Author(s)
      神野尚三
    • Organizer
      日本解剖学会第66回九州支部学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 加齢に伴うアストロサイトの空間分布様式の変化には海馬の層・領域による差異が存在する2010

    • Author(s)
      神野尚三
    • Organizer
      日本解剖学会九州支部学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stereological analysis on the age-related alterations in patterns of expression of astrocyte marker proteins S100β, GFAP and Sox2 in the mouse hippocampus, with special reference to the dorsoventral differences2010

    • Author(s)
      神野尚三
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Stereological analysis on the age-related alterations in patterns of expression of astrocyte marker proteins S100β, GFAP and Sox2 in the mouse hippocampus, with special reference to the dorsoventral differences2010

    • Author(s)
      Shozo Jinno
    • Organizer
      日本神経科学大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加齢に伴う海馬神経新生の減少には領域による差異が存在する2010

    • Author(s)
      神野尚三,小坂俊夫
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 加齢に伴う海馬神経新生の減少には領域による差異が存在する2010

    • Author(s)
      神野尚三, 小坂俊夫
    • Organizer
      日本解剖学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-03-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regional differences in proliferation and maturation of neural progenitors in the adult mouse hippocampus : A stereology-based study2009

    • Author(s)
      神野尚三,小坂俊夫
    • Organizer
      第32回日本神経科学学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Regional differences in proliferation and maturation of neural progenitors in the adult mouse hippocampus : A stereology-based study2009

    • Author(s)
      神野尚三, 小坂俊夫
    • Organizer
      日本神経科学学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Book] 現代精神医学事典2011

    • Author(s)
      神野尚三(分担執筆)
    • Total Pages
      1400
    • Publisher
      弘文堂
    • Related Report
      2011 Annual Research Report
  • [Book] 現代精神医学事典

    • Author(s)
      神野尚三. GABA
    • Publisher
      弘文堂
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.ana2.med.kyushu-u.ac.jp/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.ana2.med.kyushu-u.ac.jp/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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