Research on the structural plasticity and pathogenesis of depressive disorders

• Project/Area Number: 21500328
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kyushu University
• Principal Investigator: JINNO Shozo 九州大学, 大学院・医学研究院, 教授 (10325524)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 神経回路網 / 構造的可塑性 / ステレオロジー / うつ病 / ミクログリア / アストロサイト / ニューロン・グリア連関 / 海馬 / 舌下神経 / ミノサイクリン / グルタミン酸 / 神経変性 / 加齢 / 認知症 / 神経新生 / グリア / 神経可塑性 / 背側・腹側

Research Abstract

We carried out the neuroscience research on the morphological plasticity of neurons and glial cells constituting neuronal network, and obtained the following outcomes.(1) Adult neurogenesis in the dentate gyrus declined more severely in the ventral hippocampus than in the dorsal hippocampus.(2) Numerical densities of astrocytes increased in the stratum lacunosum-moleculare in the ventral hippocampus but not in the dorsal hippocampus with aging.(3) In the axotomy model, astrocytic, but not microglial, reaction may primarily mediate some anti-apoptotic effects through synaptic stripping.

Research Products

• [Journal Article] Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping (2012)
  • Author(s): Jinno S, Yamada J
  • Journal Title: Neuron Glia Biology Volume: 5 Issue: 1 Pages: 1-12
  • DOI: 10.1017/s1740925x11000135
  • Peer Reviewed
• [Journal Article] Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping (2011)
  • Author(s): Jinno S, Yamada J.
  • Journal Title: Neuron Glia Biol Volume: 504 Pages: 295-300
• [Journal Article] Alterations in neuronal survival and glial reactions after axotomy by ceftriaxone and minocycline in the mouse hypoglossal nucleus (2011)
  • Author(s): Yamada J, Jinno S.
  • Journal Title: Neurosci Lett Volume: 504 Pages: 295-300
• [Journal Article] Differential involvement of perineuronal astrocytes and microglia in synaptic stripping after hypoglossal axotomy (2011)
  • Author(s): Yamada J, Nakanishi H, Jinno S.
  • Journal Title: Neuroscience Volume: 182 Pages: 1-10
• [Journal Article] Regional and laminar differences in antigen profiles and spatial distributions of astrocytes in the mouse hippocampus, with reference to aging (2011)
  • Author(s): Jinno S.
  • Journal Title: Neuroscience Volume: 180 Pages: 41-52
• [Journal Article] Decline in adult neurogenesis during aging follows a topographic pattern in the mouse hippocampus (2011)
  • Author(s): Jinno S.
  • Journal Title: J Comp Neurol Volume: 519 Pages: 451-66
• [Journal Article] Topographic differences in adult neurogenesis in the mouse hippocampus : a stereology-based study using endogenous markers (2011)
  • Author(s): Jinno S.
  • Journal Title: Hippocampus Volume: 21 Pages: 467-80
• [Journal Article] Alterations in neuronal survival and glial reactions after axotomy by ceftriaxone and minocycline in the mouse hypoglossal nucleus (2011)
  • Author(s): Yamada J, Jinno S
  • Journal Title: Neuroscience letters Volume: 504 Issue: 3 Pages: 295-300
  • DOI: 10.1016/j.neulet.2011.09.051
  • Peer Reviewed
• [Journal Article] Regional and laminar differences in antigen profiles and spatial distributions of a strocytes in the mouse hippocampus, with reference to aging (2011)
  • Author(s): Jinno S
  • Journal Title: Neuroscience Volume: 180 Pages: 41-52
  • DOI: 10.1016/j.neuroscience.2011.02.013
  • Peer Reviewed
• [Journal Article] Decline in adult neurogenesis during aging follows a topographic pattern in the mouse hippocampus (2011)
  • Author(s): JINNO S
  • Journal Title: J Comp Neurol Volume: 519 Pages: 451-466
  • Peer Reviewed
• [Journal Article] Stereological estimation of numerical densities of glutamatergic principal neurons in the mouse hippocampus (2010)
  • Author(s): Jinno S, Kosaka T.
  • Journal Title: Hippocampus Volume: 20 Pages: 829-40
• [Journal Article] Cortical GABAergic Neurons : Stretching it Remarks, Main Conclusions and Discussion (2010)
  • Author(s): Clancy B, Defelipe J, Espinosa A, Fairen A, Jinno S, Kanold P, Luhmann HJ, Rockland KS, Tamamaki N, Yan XX.
  • Journal Title: Front Neuroanat Volume: 4(7) Pages: 1-18
• [Journal Article] Topographic differences in adult neurogenesis in the mouse hippocampus : A stereology-based study using endogenous markers (2010)
  • Author(s): Jinno S
  • Journal Title: Hippocampus (Published online Jan 19, 2010)
  • Peer Reviewed
• [Journal Article] Cortical GABAergic Neurons : Stretching it Remarks, Main Conclusions and Discussion (2010)
  • Author(s): Clancy B, Defelipe J, Espinosa A, Fairen A, Jinno S, Kanold P, Luhmann HJ, Rockland KS, Tamamaki N, Yan XX
  • Journal Title: Front Neuroanat 4 Pages: 1-8
• [Journal Article] Neuronal circuit-dependent alterations in expression of two isoforms of glutamic acid decarboxylase in the hippocampus following electroconvulsive shock : A stereology-based study (2009)
  • Author(s): Jinno S, Kosaka T.
  • Journal Title: Hippocampus Volume: 19 Pages: 1130-1141
• [Journal Article] Structural organization of long-range GABAergic projection system of the hippocampus (2009)
  • Author(s): Jinno S.
  • Journal Title: Front Neuroanat Volume: 3(13) Pages: 1-9
• [Journal Article] Stereological estimation of numerical densities of glutamatergic principal neurons in the mouse hippocampus (2009)
  • Author(s): Jinno S, Kosaka T
  • Journal Title: Hippocampus (Published online Aug 4, 2009)
  • Peer Reviewed
• [Journal Article] Structural organization of long-range GABAergic projection system of the hippocampus (2009)
  • Author(s): Jinno S
  • Journal Title: Front Neuroanat 3 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Differential involvement of perineuronal astrocytes and microglia in synaptic stripping after hypoglossal axotomy
  • Author(s): Yamada J, Nakanishi H, JINNO S
  • Journal Title: Neuroscience Volume: (In press)
  • Peer Reviewed
• [Presentation] ペリニューロナルネットを有するニューロンの神経化学的多様性 (2012)
  • Author(s): 関善弘,山田純,神野尚三
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府
  • Year and Date: 2012-03-26
• [Presentation] S100A6は活性化アストロサイトと神経幹細胞の選択的マーカーである (2012)
  • Author(s): 山田純、神野尚三
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府
  • Year and Date: 2012-03-26
• [Presentation] ミクログリア形態の活性化過程の経時変化 (2011)
  • Author(s): 山田純,神野尚三
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] ダイセクター法による海馬神経新生の長軸方向による差異と加齢変化の研究 (2011)
  • Author(s): 神野尚三
  • Organizer: 日本顕微鏡学会第67回学術講演会
  • Place of Presentation: 福岡
  • Year and Date: 2011-05-16
• [Presentation] ダイセクター法による海馬神経新生の長軸方向による差異と加齢変化の研究 (2011)
  • Author(s): 神野尚三
  • Organizer: 日本顕微鏡学会第67回学術講演会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-05-16
• [Presentation] マウス海馬オリゴデンドロサイトの産生・分化の加齢変化に関するステレオロジー解析 (2011)
  • Author(s): 神野尚三
  • Organizer: 第116回日本解剖学会全国学術集会
  • Place of Presentation: 東日本大震災のため日本生理学会誌上開催
  • Year and Date: 2011-03-30
• [Presentation] マウス海馬オリゴデンドロサイトの産生・分化の加齢変化に関するステレオロジー解析 (2011)
  • Author(s): 神野尚三
  • Organizer: 日本解剖学会全国学術集会
  • Place of Presentation: (東日本大震災のため日本生理学会誌上開催)
  • Year and Date: 2011-03-30
• [Presentation] 加齢に伴うアストロサイトの空間分布様式の変化には海馬の層・領域による差異が存在する (2010)
  • Author(s): 神野尚三
  • Organizer: 日本解剖学会第66回九州支部学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-08
• [Presentation] 加齢に伴うアストロサイトの空間分布様式の変化には海馬の層・領域による差異が存在する (2010)
  • Author(s): 神野尚三
  • Organizer: 日本解剖学会九州支部学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2010-10-08
• [Presentation] Stereological analysis on the age-related alterations in patterns of expression of astrocyte marker proteins S100β, GFAP and Sox2 in the mouse hippocampus, with special reference to the dorsoventral differences (2010)
  • Author(s): 神野尚三
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] Stereological analysis on the age-related alterations in patterns of expression of astrocyte marker proteins S100β, GFAP and Sox2 in the mouse hippocampus, with special reference to the dorsoventral differences (2010)
  • Author(s): Shozo Jinno
  • Organizer: 日本神経科学大会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-04
• [Presentation] 加齢に伴う海馬神経新生の減少には領域による差異が存在する (2010)
  • Author(s): 神野尚三,小坂俊夫
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-03-31
• [Presentation] 加齢に伴う海馬神経新生の減少には領域による差異が存在する (2010)
  • Author(s): 神野尚三, 小坂俊夫
  • Organizer: 日本解剖学会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-03-31
• [Presentation] Regional differences in proliferation and maturation of neural progenitors in the adult mouse hippocampus : A stereology-based study (2009)
  • Author(s): 神野尚三,小坂俊夫
  • Organizer: 第32回日本神経科学学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Regional differences in proliferation and maturation of neural progenitors in the adult mouse hippocampus : A stereology-based study (2009)
  • Author(s): 神野尚三, 小坂俊夫
  • Organizer: 日本神経科学学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-16
• [Book] 現代精神医学事典 (2011)
  • Author(s): 神野尚三(分担執筆)
  • Total Pages: 1400
  • Publisher: 弘文堂
• [Book] 現代精神医学事典
  • Author(s): 神野尚三. GABA
  • Publisher: 弘文堂
• [Remarks]
  • URL: http://www.ana2.med.kyushu-u.ac.jp/
• [Remarks]
  • URL: http://www.ana2.med.kyushu-u.ac.jp/