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Biochemical and neuropathological analysis of HtrA2 knockout mouse

Research Project

Project/Area Number 21500336
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyoto University

Principal Investigator

ITO Hidefumi  京都大学, 医学研究科, 講師 (20250061)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Ryosuke  京都大学, 医学研究科, 教授 (90216771)
KAWAMOTO Yasuhiro  京都大学, 医学研究科, 非常勤講師 (40335253)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsパーキンソン病 / HtrA2 / knockout mouse / ノックアウトマウス / Parkinson' sdisease / Parkinson's disease / Parkinson' s disease
Research Abstract

We generated HtrA2 knockout(KO) mice, and analyzed them biochemically and neuropathologically. We found that the mean survival of the homozygous HtrA2 KO mice was 30 days. In the mice, the striatum was degenerated and ubiquitinated proteins were accumulated. In addition, we found reduction of COXI, COXIV, and parkin proteins, and increase of LC3-II. Their skeletal and cardiac muscles showed atrophy. The mean survival of HtrA2/parkin double KO mice was shorter than that of HtrA2 KO mice. Moreover, we identified HtrA2 immunoreactivity in the senile plaques and the neurofibrillary tangles of Alzheimer's and in the intracytoplasmic inclusions of ALS patients.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (98 results)

All 2012 2011 2010 2009 Other

All Journal Article (44 results) (of which Peer Reviewed: 44 results) Presentation (47 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia2012

    • Author(s)
      Hase Y, Okamoto Y, Fujita Y, KitamuraA, Ito H, Maki T, Washida K, TakahashiR, Ihara M
    • Journal Title

      Experimental Neurology

      Volume: 233 Issue: 1 Pages: 523-533

    • DOI

      10.1016/j.expneurol.2011.11.038

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective white matter abnormalities in a novel rat model of vascular dementia2012

    • Author(s)
      Kitamura A, Fujita Y, Oishi N, KalariaR N, Washida K, Maki T, Okamoto Y, HaseY, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M
    • Journal Title

      Neurobiology of Aging

      Volume: 33 Issue: 5 Pages: 25-35

    • DOI

      10.1016/j.neurobiolaging.2011.10.033

    • NAID

      120003988349

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Environmental enrichment ameliorated high fat diet-induced Aβdeposition and memory deficit in APP transgenic mice2012

    • Author(s)
      Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, ShimohamaS, Kihara T, Kinoshita A
    • Journal Title

      Neurobiology of Aging

      Volume: 33 Issue: 5 Pages: 11-23

    • DOI

      10.1016/j.neurobiolaging.2011.10.028

    • NAID

      120003988394

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein disulfide isomerase immunopositivei nclusions in patients with amyotrophic lateral sclerosis2011

    • Author(s)
      Honjo Y, Kaneko S, Ito H, Horibe T, Takahashi R, Kawakami K
    • Journal Title

      Amyotrophic lateral sclerosis

      Volume: 12 Pages: 444-450

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22174512

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation2011

    • Author(s)
      Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, FujitaK, Kaneko S, Okamoto Y, Ihara M, Konishi T, Ogasawara K, Hirano A, Kusaka H, KajiR, Takahashi R, Kawakami H
    • Journal Title

      Acta Neuropathologica

      Volume: 122 Issue: 2 Pages: 223-229

    • DOI

      10.1007/s00401-011-0842-y

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Watershed Infarcts in a multiple microembolic model of monkey2011

    • Author(s)
      Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M, Tomimoto H
    • Journal Title

      Neuroscience Letters

      Volume: 499 Issue: 2 Pages: 80-83

    • DOI

      10.1016/j.neulet.2011.05.036

    • NAID

      120003238944

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein disulfide isomerase immuno positive glial cytoplasmic inclusions in patients with multiple system atrophy2011

    • Author(s)
      Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K
    • Journal Title

      International Journal of Neuroscience

      Volume: 121 Issue: 10 Pages: 543-550

    • DOI

      10.3109/00207454.2011.585440

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co localization of 14-3-3 proteins with SOD1 in Lewy Body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model2011

    • Author(s)
      Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R
    • Journal Title

      PLoS One

      Volume: 6 Issue: 5 Pages: e20427-e20427

    • DOI

      10.1371/journal.pone.0020427

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiogenic roles of adreno medullin through VEGF induction2011

    • Author(s)
      Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R
    • Journal Title

      Neuroreport

      Volume: 22 Issue: 9 Pages: 442-447

    • DOI

      10.1097/wnr.0b013e32834757e4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease2011

    • Author(s)
      Ito H, Fujita K, Nakamura M, Wate R, Kaneko S, Sasaki S, Yamane K, Suzuki N, Aoki M, Shibata N, Togashi S, Kawata A, Mochizuki Y, Mizutani T, Maruyama H, Hirano A, Takahashi R, Kawakami H, Kusaka H
    • Journal Title

      Acta Neuropathologica

      Volume: 121 Issue: 4 Pages: 555-557

    • DOI

      10.1007/s00401-011-0809-z

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The influence of chronic cerebral hypoperfusion on cognitive function and amyloid b metabolism in APP overexpressing mice2011

    • Author(s)
      Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K, Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R
    • Journal Title

      PLoS One

      Volume: 6 Issue: 1 Pages: e16567-e16567

    • DOI

      10.1371/journal.pone.0016567

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice2011

    • Author(s)
      Tomimoto H
    • Journal Title

      Stroke

      Volume: 42(4) Issue: 4 Pages: 1122-8

    • DOI

      10.1161/strokeaha.110.603399

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiogenic roles of adrenomedullin through VEGF induction2011

    • Author(s)
      Maki T, et al
    • Journal Title

      Neuroreport

      Volume: 22 Pages: 442-447

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein disulfide isomerase immunopositive inclusions in patients with amyotrophic lateral sclerosis2011

    • Author(s)
      Honjo Y, et al
    • Journal Title

      Amyotrophic lateral sclerosis

      Volume: 12 Issue: 6 Pages: 444-450

    • DOI

      10.3109/17482968.2011.594055

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clustering of multifocal cerebral infarctions in CADASIL : a case report2011

    • Author(s)
      Saito S, et al
    • Journal Title

      Journal of Neurology

      Volume: 258 Issue: 2 Pages: 325-327

    • DOI

      10.1007/s00415-010-5727-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An autopsy case of SOD1-related ALS with TDP-43 positive inclusions2011

    • Author(s)
      Okamoto Y, et al
    • Journal Title

      Neurology

      Volume: 77 Pages: 1993-1995

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish2010

    • Author(s)
      Matsui H, Ito H, Taniguchi Y, Takeda S, Takahashi R
    • Journal Title

      Journal of Neurochemistry

      Volume: 115 Issue: 5 Pages: 1150-1160

    • DOI

      10.1111/j.1471-4159.2010.07012.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Localization of HtrA2/Omi immunoreactivity in brains with Alzheimer's disease2010

    • Author(s)
      Kawamoto Y, Ito H, Ihara M, Kobayashi Y, Suzuki Y, Takahashi R
    • Journal Title

      Neuroreport

      Volume: 21 Issue: 17 Pages: 1121-1125

    • DOI

      10.1097/wnr.0b013e328340a731

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smad ubiqui tination regulatory factor-2 in progressive supranuclear palsy2010

    • Author(s)
      Nakamura M, Ito H, Nakamura Y, Wate R, Kaneko S, Nakano S, Matsumoto S, Kusaka H
    • Journal Title

      Neuropathology and Applied Neurobiology

      Volume: 37 Issue: 3 Pages: 307-314

    • DOI

      10.1111/j.1365-2990.2010.01120.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow2010

    • Author(s)
      Fujita Y, Ihara M, Ushiki T, Hirai H, Kizaka-kondoh S, Hiraoka M, Ito H, Takahashi R
    • Journal Title

      Stroke

      Volume: 41 Issue: 12 Pages: 2938-2943

    • DOI

      10.1161/strokeaha.110.596379

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteasome inhibition in medaka brain induces the features of Parkinson disease2010

    • Author(s)
      Matsui H, Ito H, Taniguchi Y, Inoue H, Takeda S, Takahashi R
    • Journal Title

      Journal of Neurochemistry

      Volume: 115 Issue: 1 Pages: 178-187

    • DOI

      10.1111/j.1471-4159.2010.06918.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to PPAR-γactivation in mice with chronic cerebral hypoperfusion2010

    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R
    • Journal Title

      Stroke

      Volume: 41 Issue: 8 Pages: 1798-1806

    • DOI

      10.1161/strokeaha.110.583948

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein disulfide 1somerase-immunopositive inclusions in patients with Alzheimer disease2010

    • Author(s)
      Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K
    • Journal Title

      Brain Research

      Volume: 1349 Pages: 90-963

    • DOI

      10.1016/j.brainres.2010.06.016

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutations of optineurin in amyotrophic lateral sclerosis2010

    • Author(s)
      Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, K
    • Journal Title

      Nature

      Volume: 465 Issue: 7295 Pages: 223-226

    • DOI

      10.1038/nature08971

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A mouse model characterizing features of vascular dementia with hippocampal atrophy2010

    • Author(s)
      Nishio K, Ihara M, Yamasaki N, KalariaRN, Maki T, Fujita Y, Ito H, Oishi N, Fukuyama H, Miyakawa T, Takahashi R, Tomimoto H
    • Journal Title

      Stroke

      Volume: 41 Issue: 6 Pages: 1278-1284

    • DOI

      10.1161/strokeaha.110.581686

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn of patients with sporadic and SOD1 mutant amyotrophic lateral sclerosis2010

    • Author(s)
      Kawamoto Y, Ito H, Kobayashi Y, Suzuki Y, Akiguchi I, Fujimura H, Sakoda S, Kusaka H, Hirano A, Takahashi R
    • Journal Title

      Neuropathology and Applied Neurobiology

      Volume: 36 Issue: 4 Pages: 331-344

    • DOI

      10.1111/j.1365-2990.2010.01075.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Localization of HtrA2/Omi immunoreactivity, in brains with Alzheimers sdisease.2010

    • Author(s)
      Kawamoto Y, Ito H, et al
    • Journal Title

      Neuroreport

      Volume: 21 Pages: 1121-1125

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations of optineurin in amyotrophic lateral sclerosis.2010

    • Author(s)
      Maruyama H, Morino, H, Ito H, et al
    • Journal Title

      Nature

      Volume: 465 Pages: 223-226

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteasome inhibitionR in Medaka brain induces the featuresof Parkinson disease2010

    • Author(s)
      Matsui H, Ito H, et al.
    • Journal Title

      Journal of Neurochemistry

      Volume: 115 Pages: 178-187

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish.2010

    • Author(s)
      Matsui H, Ito H, et al
    • Journal Title

      Journal of Neurochemistry

      Volume: 115 Pages: 1150-1160

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smad ubiquitination regulatory factor-2 in progressive supranuclear palsy.2010

    • Author(s)
      Nakamura M, Ito H, et al
    • Journal Title

      Neuropathology and Applied Neurobiology

      Volume: 37 Pages: 307-314

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein Disulfide Isomerase-immunopositive Inclusions in patients with Alzheimer disease.2010

    • Author(s)
      Hoiijo Y, Ito H, et al
    • Journal Title

      Brain Research

      Volume: 1349 Pages: 90-96

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mouse model characterizing features of vascular dementia with hippo campal atrophy.2010

    • Author(s)
      Nishio K Ihara M, et al
    • Journal Title

      Stroke

      Volume: 41 Pages: 1278-1284

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partially due to PPAR-γ Activation in Mice with Chronic Cerebral Hypoperfion.2010

    • Author(s)
      Washida K, Ihara M, et al
    • Journal Title

      Stroke

      Volume: 41 Pages: 1798-1806

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow.2010

    • Author(s)
      Fujita Y, Ihara M, et al
    • Journal Title

      Stroke

      Volume: 41 Pages: 2938-2943

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn of patients with sporadic and SOD1 mutant amyotrophic lateral sclerosis.2010

    • Author(s)
      Kawamoto Y, et al
    • Journal Title

      Neuropathol Appl Neurobiol. 36(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear Contour Irregularity and Abnormal Transporter Protein Distribution in Anterior Horn Cells in ALS2009

    • Author(s)
      Kinoshita Y, Ito H, Hirano A, Fujita K, Wate R, Nakamura M, Kaneko S, Nakano S, Kusaka H
    • Journal Title

      Journal of Neuropathology and Experimental Neurology

      Volume: 68 Pages: 1184-1192

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/19816199

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis2009

    • Author(s)
      Ohnishi S, Ito H, Suzuki Y, Adachi Y, Wate R, Zhang JH, Nakano S, Kusaka H, Ikehara S
    • Journal Title

      Brain Research

      Volume: 1296 Pages: 216-224

    • DOI

      10.1016/j.brainres.2009.08.012

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia2009

    • Author(s)
      Okamoto Y, Ihara M, Fujita Y, Ito H, Takahashi R, Tomimoto H
    • Journal Title

      Neuroreport

      Volume: 20 Issue: 11 Pages: 990-996

    • DOI

      10.1097/wnr.0b013e32832d2e6a

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Screening for TARDBP mutations in Japanese familial amyotrophic lateral sclerosis2009

    • Author(s)
      Kamada M, Maruyama H, Tanaka E, Morino H, Wate R, Ito H, Kusaka H, Kawano Y, Miki T, Nodera H, Izumi Y, Kaji R, Kawakami H
    • Journal Title

      Journal of The Neurological Sciences

      Volume: 284 Issue: 1-2 Pages: 69-71

    • DOI

      10.1016/j.jns.2009.04.017

    • NAID

      120001898369

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear contour irregularity and abnormal transporter protein distribution in anterior horn cells in amyotrophic lateral sclerosis.2009

    • Author(s)
      Kinoshita Y, et al
    • Journal Title

      J Neuropathol Exp Neurol 68

      Pages: 1184-1192

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis.2009

    • Author(s)
      Ohnishi S, et al
    • Journal Title

      Brain Res 1296

      Pages: 216-224

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia.2009

    • Author(s)
      Okamoto Y, et al
    • Journal Title

      Neuroreport. 20

      Pages: 990-996

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening for TARDBP mutations in Japanese familial amyotrophic lateral sclerosis.2009

    • Author(s)
      Kamada M, et al
    • Journal Title

      J Neurol Sci 284

      Pages: 69-71

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Autophagy-related proteins immunoreactivity in basophilic inclusion body2011

    • Author(s)
      Fujita K, (3名略), Ito H, (1名略)
    • Organizer
      19th Annual Meeting International Alliance of ALS/MND Associations
    • Place of Presentation
      Sydney,オーストラリア
    • Year and Date
      2011-11-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] An autopsy case of amyotrophic lateral sclerosis associated with I113T2011

    • Author(s)
      Nakamura S, (5名略), Ito H, (3名略)
    • Organizer
      19th Annual Meeting International Alliance of ALS/MND Associations
    • Place of Presentation
      Sydney,オーストラリア
    • Year and Date
      2011-11-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Alzheimer病患者脳内におけるHtrA2/Omiの免疫組織化学的検討2011

    • Author(s)
      河本恭裕、伊東秀文, 他
    • Organizer
      第52回日本神経病理学会
    • Place of Presentation
      京都
    • Year and Date
      2011-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 筋萎縮性側索硬化症の脊髄に於けるvalosin-containing proteinの免疫組織化学的検討2011

    • Author(s)
      池本明人, (2名略)、高橋良輔、伊東秀文
    • Organizer
      第52回日本神経病理学会総会
    • Place of Presentation
      京都(京都テルサ)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Alzheimer病患者脳内におけるHtrA2/Omiの免疫組織化学的検討2011

    • Author(s)
      河本恭裕、伊東秀文, (2名略)、高橋良輔
    • Organizer
      第52回日本神経病理学会総会
    • Place of Presentation
      京都(京都テルサ)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳低灌流がアミロイド血管症による虚血・出血を加速する2011

    • Author(s)
      岡本洋子, (3名略)、伊東秀文, (3名略), 高橋良輔
    • Organizer
      第52回日本神経病理学会総会
    • Place of Presentation
      京都(京都テルサ)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳低灌流がアミロイド血管症による虚血・出血を加速する2011

    • Author(s)
      岡本洋子, (3名略)、伊東秀文, (3名略)、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 好塩基性封入体を伴う成人発症運動ニューロン病におけるoptineurinの関与2011

    • Author(s)
      藤田賢吾、伊東秀文, (5名略)
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] アメロイドコンストリクターを用いた新規ラット皮質下血管性認知症モデルの作成2011

    • Author(s)
      北村彰浩, (4名略)、伊東秀文、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] シロスタゾールによるrtPA治療後の出血、浮腫の抑制効果2011

    • Author(s)
      長谷佳樹, (2名略)、伊東秀文、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 変異SOD1を有するALS患者由来iPS細胞の樹立とアストロサイトへの分化2011

    • Author(s)
      北岡志保, (8名略)、伊東秀文, (8名略)、高橋良輔, (1名略)
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経変性モデル作製のための26Sロテアソームコンディショナルノックアウトマウスの確立と解析2011

    • Author(s)
      田代善崇、伊東秀文, (5名略)、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性脳低灌流はタウオパチーモデルマウスのタウ毒性を加速する2011

    • Author(s)
      山田真人, (2名略)、伊東秀文, (2名略)、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス慢性脳低灌流モデルの認知機能障害および白質病変に対するニフェジピンの効果2011

    • Author(s)
      鷲田和夫, (1名略)、伊東秀文, (1名略)、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Optineurin in ALS2011

    • Author(s)
      Kawakami H, Maruyama H, Ito H
    • Organizer
      AAN-JSN Joint Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2011-05-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳幹型および皮質型Lewy小体におけるXIAPとHtrA2/Omiの共存2011

    • Author(s)
      河本恭裕、伊東秀文, 他
    • Organizer
      第52回日本神経学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Optineurin in ALS2011

    • Author(s)
      Kawakami H, Maruyama H, Ito H
    • Organizer
      第52回日本神経学会学術大会AAN-JSN Joint Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] アルツハイマー病における抗PDI抗体陽性封入体2011

    • Author(s)
      本城靖之、伊東秀文, (3名略)
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] モントリオール認知評価法MoCAはMMSEよりも皮質下血管性認知障害の検出感度が高い2011

    • Author(s)
      猪原匡史, (1名略)、伊東秀文、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 常染色体劣性optineurin遺伝子変異による筋萎縮性側索硬化症2011

    • Author(s)
      鎌田正紀, (1名略)、伊東秀文, (5名略)
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症に於けるvalosin-containing protein発現の検討2011

    • Author(s)
      池本明人, (2名略)、高橋良輔、伊東秀文
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症の原因遺伝子オプチニューリンの同定および頻度・臨床症状2011

    • Author(s)
      丸山博文, (1名略)、伊東秀文, (11名略)
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 霊長類多発脳梗塞モデルのMRI画像2011

    • Author(s)
      眞木崇州, (6名略)、伊東秀文、高橋良輔, (1名略)
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳幹型および皮質型Lewy小体におけるXIAPとHtrA2/Omiの共存2011

    • Author(s)
      河本恭裕、伊東秀文, (3名略)、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 進行性核上性麻痺におけるSmurf2の免疫組織化学的検討2011

    • Author(s)
      中村正孝, (1名略)、伊東秀文, (3名略)
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] OPTN and Motor neuron disease2011

    • Author(s)
      Kawakami H, Maruyama H, Ito H
    • Organizer
      International Symposium on Motor Neuron Disease and Perry Syndrome
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2011-02-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical and Neuropathologic Investigation of a Family with ALS Associated with Mutated Optineurin2010

    • Author(s)
      Ito H, Nakamura M, Komure O, et al.
    • Organizer
      第17回国際神経病理学会
    • Place of Presentation
      ザルツブルグ, オーストリア
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] OPTN遺伝子変異例の臨床病理学的検討2010

    • Author(s)
      伊東秀文
    • Organizer
      厚生労働省障害者対策総合研究事業(神経・筋疾患分野) ALS/ALSD/FTLDU Consortium 2010サマーワークショップ特別講演
    • Place of Presentation
      東京
    • Year and Date
      2010-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Alzheimer病患者脳内におけるOmi/HtrA2の免疫組織化学的検討2010

    • Author(s)
      河本恭裕、伊東秀文, 他
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Alzheimer病患者脳内におけるOmi/HtrA2の免疫組織化学的検討2010

    • Author(s)
      河本恭裕、伊東秀文, 他
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ガイドラインに基づいたパーキンソン病の非運動症状の治療2010

    • Author(s)
      伊東秀文
    • Organizer
      第51回日本神経学会総会スポンサードセミナー
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical and Neuropathologic Investigation of a Family with ALS Associated with Mutated Optineurin2010

    • Author(s)
      Ito H, Nakamura M, Komure O, Maruyama M, Wate R, Nakamura Y, Fujita K, Kaneko S, Ogasawara O, Nakabayashi H, Ayaki T, Okamoto Y, Ihara M, Kaji R, Kusaka H, Hirano A, Takahashi R, Kawakami H
    • Organizer
      XVIIth International Congress of Neuropathology
    • Place of Presentation
      Salzburg, Austria
    • Related Report
      2011 Final Research Report
  • [Presentation] Smad ubiquitination regulatory factor-2 in progressive supranuclear palsy2010

    • Author(s)
      Nakamura M, Ito H, Kaneko S, Asayama S, Nakamura S, Nishii M, Fujita K, Matsumoto S, Kusaka H
    • Organizer
      XVIIth International Congress of Neuropathology
    • Place of Presentation
      Salzburg, Austria
    • Related Report
      2011 Final Research Report
  • [Presentation] An immunohistochemical study on basophilic inclusions of adult-onset atypical motor neuron disease2010

    • Author(s)
      Fujita K, Kaneko S, Ito H, Nishii M, Wate R, Nakano S, Kusaka H
    • Organizer
      XVIIth International Congress of Neuropathology
    • Place of Presentation
      Salzburg, Austria
    • Related Report
      2011 Final Research Report
  • [Presentation] Cortical microinfarcts are related to cerebral amyloid angiopathy rather than to senile plaques or neurofibrillary tangles2010

    • Author(s)
      Okamoto Y, Ihara M, Ito H, Yamamoto T, Tomimoto H, Takahashi R
    • Organizer
      XVIIth International Congress of Neuropathology
    • Place of Presentation
      Salzburg, Austria
    • Related Report
      2011 Final Research Report
  • [Presentation] A Mouse Model Characterizing Features of Vascular Dementia with Hippocampal Atrophy2010

    • Author(s)
      Ihara M, Nishio K, Kakaria RN, Maki T, Fujita Y, Ito H, Oishi N, Fukuyama H, Takahashi R, Tomimoto H
    • Organizer
      XVIIth International Congress of Neuropathology
    • Place of Presentation
      Salzburg, Austria
    • Related Report
      2011 Final Research Report
  • [Presentation] Cortical microinfarcts are related to cerebral amyloid angiopathy rather than to senile plaques or neurofibrillary tangles2010

    • Author(s)
      Okamoto Y, Ihara M, Ito H, Yamamoto T, Tomimoto H, Takahashi R
    • Organizer
      The 40th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 長期の臨床経過を示した孤発性筋萎縮性側索硬化症の一剖検例2009

    • Author(s)
      西井誠, 他
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松市
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] レボドパ反応性でパーキンソン病様の経過をたどった進行性核上性麻痺の1部検例2009

    • Author(s)
      中村聖香, 他
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松市
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症患者の脊髄前角細胞におけるOmi/HtrA2の集積2009

    • Author(s)
      河本恭裕、伊東秀文, 他
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-06-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 筋萎縮性側索硬化症患者の脊髄前角細胞におけるOmi/HtrA2の集積2009

    • Author(s)
      河本恭裕, 他
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松市
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 海馬歯状回顆粒神経細胞にユビキチン封入体を有する筋萎縮性側索硬化症の検討2009

    • Author(s)
      池本明人, 他
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松市
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of treatment with bone marrow mononuclear cells in a mouse model of chronic cerebral hypoperfusion2009

    • Author(s)
      Fujita Y, Ihara M, Ito H, Takahashi R
    • Organizer
      The 39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] The protective effect of telmisartan against chronic cerebral hypoperfusion in mice2009

    • Author(s)
      Washida K, Takahashi R, Takahashi J, Wu X, Kihara T, Tomimoto H, Ihara M, Ito H
    • Organizer
      The 39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Adrenomedullin promotes angiogenesis and arteriogenesis and preserves white matter integrity after chronic cerebral hypoperfusion in mice2009

    • Author(s)
      Maki T, Fujita Y, Ihara M, Ito H, Tomimoto H, Takahashi R
    • Organizer
      The 39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Protective effect of Cilostazol against the no-reflow phenomenon in transient cerebral ischemia2009

    • Author(s)
      Hase Y, Ihara M, Fujita Y, Ito H, Takahashi R
    • Organizer
      The 39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia2009

    • Author(s)
      Okamoto Y, Ihara M, Fujita Y, Ito H, Tomimoto H, Takahashi R
    • Organizer
      The 39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Book] これからのパーキンソン病治療「ガイドラインサポートハンドブックパーキンソン病」武田篤編2011

    • Author(s)
      伊東秀文
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Final Research Report
  • [Book] パーキンソン病「ガイドライン外来診療2011」泉孝英編2011

    • Author(s)
      伊東秀文、高橋良輔
    • Publisher
      日経メディカル開発
    • Related Report
      2011 Final Research Report
  • [Book] パーキンソン症候群(SND, PSP, CBD)「研修医のための神経内科診療」阿部康二編2010

    • Author(s)
      伊東秀文、高橋良輔
    • Publisher
      新興医学出版社
    • Related Report
      2011 Final Research Report
  • [Book] 研修医のための神経内科診療(阿部康二編著)2010

    • Author(s)
      伊東秀文
    • Total Pages
      279
    • Publisher
      新興医学出版社
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~neurology/

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] TDP-43の凝集体が蓄積する疾患の発症リスクを予測する方法、診断薬及び治療薬2012

    • Inventor(s)
      漆谷真、藤原範子、伊東秀文
    • Industrial Property Rights Holder
      滋賀医科大学、兵庫医科大学、京都大学
    • Filing Date
      2012-02-13
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] TDP-43の凝集体が蓄積2012

    • Inventor(s)
      漆谷真、藤原
    • Industrial Property Rights Holder
      滋賀医科大
    • Industrial Property Number
      2012-028737
    • Filing Date
      2012-02-13
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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