| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
This study showed that adrenomedullin(AM), which is reported as antioxidative peptide, has an important protective function against oxidative stress through the cyclic AMP. protein kinase A pathway. We indicated that downregulation of AM results in high levels of reactive oxygen species(ROS) and enhanced progression of infarction area after transient focal ischemia in mice. In chronic cerebral hypoperfusion of AM deficient mice, oxidative stress and inflammatory response enhanced progression of white matter damages. It suggest that augmentation or activation for AM may be suppressed oxdative stress and shown the brain protective effect.
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