Neuropathological reserch of TDP-43 proteinopathy
| Project/Area Number |
21500339
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | Aichi Medical University |
|---|
Principal Investigator |
YOSHIDA Mari 愛知医科大学, 加齢医科学研究所, 教授 (60288545)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 神経変性疾患 / TDP-43 / 筋萎縮性側索硬化症 / 前頭側頭葉変性症 / ユビキチン / 筋萎縮性側索硬化症(ALS) / 前頭側頭葉変性症(FTLD-TDP) / 変性突起 / 神経細胞胞体内封入体 / 前頭側頭葉変性症(FTLD-U) / ユビキチン化封入体 / 点変異 / 認知症を伴う筋萎縮性側索硬化症 / Perry症候群 |
|---|
| Research Abstract |
We investigated neuropathology of TDP-43-positive inclusions of amyotrophic lateral sclerosis(ALS) and frontotemporal lobar degeneration(FTLD) in autopsied brains. TDP-43-positive inclusions were found beyond motor neuron system in ALS brains, and in motor neuron system in FTLD brains, while the cellular and distribution of inclusions showed differences between two diseases. We confirmed the common pathological basis encompassing ALS and FTLD.
|
Report
(4 results)
Research Products
(81 results)
