| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
We investigated neuropathology of TDP-43-positive inclusions of amyotrophic lateral sclerosis(ALS) and frontotemporal lobar degeneration(FTLD) in autopsied brains. TDP-43-positive inclusions were found beyond motor neuron system in ALS brains, and in motor neuron system in FTLD brains, while the cellular and distribution of inclusions showed differences between two diseases. We confirmed the common pathological basis encompassing ALS and FTLD.
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