Research for scientific evidences on diagnostic epilepsy pathology
Project/Area Number |
21500342
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | 財団法人東京都医学総合研究所 (2011) Tokyo Metropolitan Organization for Medical Research (2009-2010) |
Principal Investigator |
ARAI Nobutaka 財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 参事研究員 (10167984)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | てんかん / 脳外科治療 / 外科病理診断 / アストロサイト / 組織鉄 / 外傷性てんかん / 限局性皮質異形成 / てんかん外科手術 / 脳形成異常 / 鉄暴露 / 神経可塑性 / 海馬硬化 / 脳炎 |
Research Abstract |
The specific aim of this study is focused on disclosing of pathological changes, if any, causing intractable epilepsy. Both of abnormal deposit of iron granules in the astrocytes and abnormal immunohistochemial expression of glutamate transporter of glia type were observed in normal-looking area around organic lesions, taken from epileptogenic cortices by neurosurgical procedures. Those findings strongly suggest a possibility that dysfunction of the astrocytes causes epilepsy.
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Report
(4 results)
Research Products
(20 results)
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[Presentation] てんかんの病理2011
Author(s)
新井信隆
Organizer
第46回日本てんかん外科学会総会
Place of Presentation
広島市(招待講演)
Year and Date
2011-01-21
Related Report
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