Search for the epigenetic transcription factor related to fear extinction

• Project/Area Number: 21500344
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Chiba University
• Principal Investigator: SHIMIZU Eiji 千葉大学, 大学院・医学研究院, 教授 (00292699)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 恐怖消去 / 感覚ゲート機構 / NMDA受容体 / DNAメチル化 / 調整誘発電位P50 / 聴性誘発電位P50 / 聴覚誘発電位P50 / メチルドナー / セロトニン再取込阻害 / プレパルス抑制

Research Abstract

To investigate what the change of DNA methylation in the brain alter behavior, mice were fed with methyl donor deficient diet in their 3wk to 6wk age. Difference in expression of NMDA receptor NR2B subunit in the hippocampus was considered as a cause of the behavioral change after the diet. In human, our results suggested that auditory evoked potential P50 differed according to the cognition of the properties (potentially dangerous or safe) of the perceived signal.

Research Products

• [Journal Article] P50 suppression in human discrimination fear conditioning paradigm using danger and safety signals (2012)
  • Author(s): Kurayama T, Matsuzawa D, Komiya Z, Nakazawa K, Yoshida S, Shimizu E
  • Journal Title: International Journal of Psychophysiology Volume: 84(1) Issue: 1 Pages: 26-32
  • DOI: 10.1016/j.ijpsycho.2012.01.004
  • Peer Reviewed
• [Journal Article] OCDの事象関連電位と感覚ゲート機構 (2011)
  • Author(s): 清水栄司
  • Journal Title: 精神神経学雑誌 Volume: 113 Pages: 54-55
  • NAID: 10028060486
• [Journal Article] 感覚ゲート機構と恐怖消去 (2011)
  • Author(s): 清水栄司
  • Journal Title: 分子精神医学 Volume: 11 Pages: 60-63
• [Journal Article] Effects of aripiprazole on MK-801-induced prepulse inhibition deficits and mitogen-activated protein kinase signal transduction pathway (2010)
  • Author(s): Ishii D, Matsuzawa D, Kanahara N , Matsuda S, Sutoh C, Ohtsuka H, Nakazawa K, Kohno M, Hashimoto K, Iyo M, Shimizu E
  • Journal Title: Neuroscience Letters Volume: 471(1) Issue: 1 Pages: 53-57
  • DOI: 10.1016/j.neulet.2010.01.010
  • Peer Reviewed
• [Journal Article] Effects of aripiprazole on MK-801-induced prepulse inhibition deficits and mitogen-activated protein kinase signal transduction pathway. (2010)
  • Author(s): Ishii D, Matsuzawa D, Kanahara N, Matsuda S, Sutoh C, 0htsuka H, Nakazawa K, Kohno M, Hashimoto K, lyo M, Shimizu E
  • Journal Title: Neurosci Leftt Volume: 471(1) Pages: 53-57
  • Peer Reviewed
• [Journal Article] d-serine enhances extinction of auditory cued fear conditioning via ERK1/2 phosphorylation in mice. (2010)
  • Author(s): Matsuda S, Matsuzawa D, Nakazawa K, Sutoh C, OhtsukaH, Ishii D, Tomizawa H, lyo M, Shimizu E.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. Volume: 34(6) Pages: 895-902
  • Peer Reviewed
• [Journal Article] Enhancement of acoustic prepulse inhibition by contextual fear conditioning in mice is maintained even after contextual fear extinction. (2010)
  • Author(s): Ishii D, Matsuzawa D, Fujita Y, Sutoh C, Ohtsuka H, Matsuda S, Kanahara N, Hashimoto K, Iyo M, Shimizu E.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 34(1) Pages: 183-188
  • Peer Reviewed
• [Journal Article] Impaired P50 suppression in fear extinction in obsessive-compulsive disorder. (2010)
  • Author(s): Nanbu M, Kurayama T, Nakazawa K, Matsuzawa D, Komiya Z, Haraguchi T, Ogura H, Hashimoto T, Yoshida S, Iyo M, Shimizu E.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 34(2) Pages: 317-322
  • Peer Reviewed
• [Journal Article] Impaired P50 suppression in fear extinction in obsessive-compulsive disorder (2009)
  • Author(s): Nanbu M, Kurayama T, Nakazawa K, Matsuzawa D , Komiya Z, Haraguchi T, Ogura H, Hashimoto T, Yoshida S, Iyo M, Shimizu E
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 34(2) Issue: 2 Pages: 317-22
  • DOI: 10.1016/j.pnpbp.2009.12.005
  • Peer Reviewed
• [Presentation] 不安障害の曝露療法の生物学と新薬の開発 (2012)
  • Author(s): 清水栄司
  • Organizer: 第13回日本サイコセラピー学会(シンポジウム)
  • Place of Presentation: 大阪国際会議場
• [Presentation] Persistent fear relief effect of social buffering in fear conditioned mice (2011)
  • Author(s): 富澤はるな, 松澤大輔, 石井大典, 松田真悟, 清水栄司
  • Organizer: NEUROSCIENCE
  • Place of Presentation: ワシントンDC(アメリカ)
  • Year and Date: 2011-11-16
• [Presentation] Erasure effects of an isolated retrieval trial on fear memory in hippocampus-dependent fear renewal paradigm (2011)
  • Author(s): 石井大典, 松澤大輔, 松田真悟, 富澤はるな, 須藤千尋, 中澤健, 清水栄司
  • Organizer: NEUROSCIENCE
  • Place of Presentation: ワシントンDC(アメリカ)
  • Year and Date: 2011-11-11
• [Presentation] 強迫性障害の診断と治療 (2011)
  • Author(s): 清水栄司
  • Organizer: 第1回埼玉うつ・不安障害治療研究会埼玉精神神経センター
  • Year and Date: 2011-11-10
• [Presentation] 認知療法と生物学的要困 (2011)
  • Author(s): 松澤大輔、清水栄司
  • Organizer: 日本認知療法学会
  • Place of Presentation: 大阪国際会議場(招待講演)
  • Year and Date: 2011-10-01
• [Presentation] CBTの生物学的基盤 (2011)
  • Author(s): 松澤大輔、清水栄司
  • Organizer: 日本生物学的精神医学会
  • Place of Presentation: ホテルグランパシフィック(招待講演)
  • Year and Date: 2011-05-21
• [Presentation] Effects of methionine, choline and folic acid-deficient diet at the developmental period on anxiety and fear in mice (2010)
  • Author(s): 石井大典
  • Organizer: 第40回NEUROSCIENCE 2010
  • Place of Presentation: San Diego Convention Center
  • Year and Date: 2010-11-13
• [Presentation] パニック障害の診断と治療 (2010)
  • Author(s): 清水栄司
  • Organizer: パニック障害セミナー
  • Place of Presentation: 札幌
  • Year and Date: 2010-08-28
• [Presentation] パニック障害の認知行動療法 (2010)
  • Author(s): 清水栄司
  • Organizer: 第6回うつ病・不安障害フォーラム西鉄グランドホテル
  • Place of Presentation: 福岡
  • Year and Date: 2010-05-27
• [Presentation] OCDの病態仮説と治療理論OCDの事象関連電位と感覚ゲート機構心理職とのこれからの協働を考える専門的治療(認知行動療法)の立場から (2010)
  • Author(s): 清水栄司
  • Organizer: 第106回日本精神神経学会学術総会広島国際会議場
  • Place of Presentation: 広島
• [Presentation] Developmental effects of one-carbon nutrients-deficient diet on anxiety and fear (2010)
  • Author(s): 石井大典、松澤大輔、須藤千尋、松田真悟、富澤はるな、清水栄司
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] Differences of P50 suprression under two distinct signals in human fear conditioning paradigm (2010)
  • Author(s): Taichi kurayama, Daisuke Matsuzawa, Zen Komiya, Ken Nakazawa Chihiro Suto, Eiji Shimizu.
  • Organizer: 29th International Congress of Clinical Neurophysiology(ICCN 2010)
  • Place of Presentation: Portopia Hotel, Kobe international conference centor
• [Presentation] Motor task difficulty and brain activity : Investigation of the wolf motor function test using near-infrared spectroscopy. (2010)
  • Author(s): Taichi Kurayama, Tomofumi Yamaguchi, Zen Komiya, Yohei Otaka, Kotaro Takeda, Rieko Osu, Shigeo Tanabe Daisuke Matsuzawa, Eiji Shimizu
  • Organizer: Neuroscience 2010
  • Place of Presentation: San Diego Convention Center
• [Presentation] マウスの恐怖消去におけるD-セリンの効果(Effects of D-serine on fear extinction in mice) (2009)
  • Author(s): 松田真悟、金原信久、松澤大輔、中澤健、伊豫雅臣、清水栄司
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] マウスにおける文脈的恐怖条件づけによるPrepulse inhibition(PPI)の増強(Enhancement of prepulse inhibition by fear conditioning in mice) (2009)
  • Author(s): 石井大典、松澤大輔、藤田有子、中澤健、伊豫雅臣、清水栄司
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Remarks]
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