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Regulation of synaptic vesicle exocytosis by soluble proteins

Research Project

Project/Area Number 21500346
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionNiigata University

Principal Investigator

ABE Teruo  新潟大学, 脳研究所, 非常勤講師 (50010103)

Co-Investigator(Renkei-kenkyūsha) YAO Hiromu  東北大学, 大学院・生命科学研究科, 教授 (00144353)
YAMADA Mitsunori  独立行政法人国立病院機構, さいがた病院・検査部, 部長 (30240039)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経伝達物質放出 / 可溶性タンパク質 / シナプス小胞 / ノックアウト
Research Abstract

To understand the mechanisms by which soluble proteins such as Munc18-1, tomosyn 1 and synaphin/complexin regulate synaptic vesicle exocytosis, we generated hippocampal CA3-specific knockout(KO) mice of Munc18-1 and tomosyn 1. Neuronal degeneration was already apparent 1week after birth in mice lacking the Munc18-1 gene in the CA3 region, rendering the analysis of synaptic transmission difficult. Tomosyn 1 KO mice exhibited larger EPSPs and smaller paired pulse facilitations. The involvement of the binding of the synaphin C-terminal region with synaptotagmin 1 in dense-core vesicle exocytosis from PC12 cessl was suggested.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010 2009

All Journal Article (3 results) Presentation (4 results)

  • [Journal Article] シナプス小胞の開口放出におけるシナフィンの機能2010

    • Author(s)
      得丸博史、清水岡部千草、阿部輝雄
    • Journal Title

      生体の科学

      Volume: 61巻 Pages: 247-251

    • Related Report
      2011 Final Research Report
  • [Journal Article] シナフィン/コンブレキシンの神経伝達物質放出における役割2010

    • Author(s)
      阿部輝雄、得丸博史
    • Journal Title

      生体の科学

      Volume: 61巻 Pages: 530-531

    • Related Report
      2011 Final Research Report
  • [Journal Article] シナフィン/コンプレキシンの神経伝達物質放出における役割2010

    • Author(s)
      阿部輝雄、得丸博史
    • Journal Title

      生体の科学

      Volume: 61 Pages: 530-531

    • Related Report
      2010 Annual Research Report
  • [Presentation] Synaptotamin1のSynaphin/complexin-C末部への結合は、小胞開口放出に重要である2011

    • Author(s)
      清水-岡部千草、篠原巧、坪井貴司、阿部輝雄、得丸博史
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Synaptotagmin 1のSynaphin/complexin-C末部への結合は、小胞開口放出に重要である2011

    • Author(s)
      清水一岡部千草、篠原巧、坪井貴司、阿部輝雄, 得丸博史
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] シナフィン/コンブレキシンはSNARE複合体にシナプトタグミン1を動員する2009

    • Author(s)
      得丸博史、清水-岡部千草、篠原巧、阿部輝雄
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2009-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] シナーフィン/コンプレキシンはSNARE複合体にシナプトタグミン1を動員する2009

    • Author(s)
      得丸博史、清水-岡部千草、篠原巧阿部輝雄
    • Organizer
      日本神経科学学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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