Analysis of the molecular mechanism of the repair of demyelination
Project/Area Number |
21500349
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OISO Yutaka 名古屋大学, 医学系研究科, 教授 (40203707)
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Co-Investigator(Renkei-kenkyūsha) |
SAWADA Makoto 名古屋大学, 環境医学研究所, 教授 (10187297)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | グリア細胞 / レーザーマイクロダイセクション / 脱髄 |
Research Abstract |
Osmotic demyelination syndrome(ODS) is a central demyelinating disease associated with a rapid correction of hyponatremia. To clarify the role of microglia in the pathogenesis of ODS, We used laser-capture microdissection to isolate single microglia and analyzed single-microglia gene-expression profiles using high-throughput microarray assays. Our data provide a new insight into the characteristic of microglia associated with injured oligodendrocytes and new molecular targets of minocycline treatment.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Poly(A) tail length of neurohypophysial hormones is shortened under endoplasmic reticulum stress2011
Author(s)
Morishita Y, Arima H, Hiroi M, Hayashi M, Hagiwara D, Asai N, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Takahashi M, Oiso Y
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Journal Title
Endocrinology
Volume: 152(12)
Pages: 4846-55
Related Report
Peer Reviewed
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[Journal Article] Time-dependent Changes in Proinflammatory and Neurotrophic Responses of Microglia and Astrocytes in a Rat Model of Osmotic Demyelination Syndrome2011
Author(s)
Iwama S, Sugimura Y, Suzuki H, Suzuki H, Murase T, Ozaki N, Nagasaki H, Arima H, Murata Y, Sawada M, Oiso Y
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Journal Title
GLIA
Volume: 59
Pages: 452-62
Related Report
Peer Reviewed
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[Journal Article] Poly(A) Tail Length of Neurohypophysial Hormones Is Shortened Under Endoplasmic Reticulum Stress2011
Author(s)
Morishita Y, Arima H, Hiroi M, Hayashi M, Hagiwara D, Asai N, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Takahashi M, Oiso Y
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Journal Title
Endocrinology
Volume: 152
Pages: 4846-4855
Related Report
Peer Reviewed
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[Journal Article] Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome2010
Author(s)
Iwama S, Sugimura Y, Suzuki H, Suzuki H, Murase T, Ozaki N, Nagasaki H, Arima H, Murata Y, Sawada M, Oiso Y
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Journal Title
Glia
Volume: 59
Pages: 452-462
Related Report
Peer Reviewed
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[Journal Article] Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes2009
Author(s)
Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y
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Journal Title
Diabetologia
Volume: 52
Pages: 962-71
Related Report
Peer Reviewed
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[Journal Article] Prevention of neural tube defects in fetuses of streptozotocin-induced diabetic mice by loss of function of inducible nitric oxide synthase2009
Author(s)
Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y
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Journal Title
Diabetologia 52
Pages: 962-971
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
椙村益久 大磯ユタカ
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Journal Title
高ナトリウム血症 内分泌・糖尿病科(科学評論社)
Pages: 393-400
Related Report
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[Presentation] The differing roles of nitric oxide synthase isoforms in osmotic demyelination syndrome inrats2009
Author(s)
Sugimura Y, Murase T, Takefuji S, Takagi H, Suzuki H, Iwama S, Takagishi Y, Arima H, Sawada M, Oiso Y, Murata Y
Organizer
Neuroscience
Place of Presentation
Chicago
Year and Date
2009-10-19
Related Report
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[Presentation] The differing roles of nitric oxide synthase isoforms in osmotic demyelination syndrome in rats2009
Author(s)
Sugimura Y, Murase T, Takefuji S, Takagi H, Suzuki H, Iwama S, Takagishi Y, Arima H, Sawada M, Oiso Y, Murata Y
Organizer
Neuroscience 2009
Place of Presentation
シカゴ
Year and Date
2009-10-18
Related Report
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[Presentation] The differing pathological effects of nitric oxide synthase is forms in osmotic demyelination syndrome in rats2009
Author(s)
Sugimura Y, Murase T, Takefuji S, Takagi H, Iwama S, Suzuki H, Takagishi Y, Arima H, Sawada M, Oiso Y, Murata Y
Organizer
The 32nd ANNUAL MEETING OF THEJAPAN NEUROSCIENCE SOCIETY
Place of Presentation
名古屋
Year and Date
2009-09-17
Related Report
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[Presentation] The differing pathological effects of nitric oxide synthase isoforms in osmotic demyelination syndrome in rats2009
Author(s)
Sugimura Y, Murase T, Takefuji S, Takagi H, Iwama S, Suzuki H, Takagishi Y, Arima H, Sawada M, Oiso Y, Murata Y
Organizer
The 32nd ANNUAL MEETING OF THE JAPAN NEUROSCIENCE SOCIETY
Place of Presentation
名古屋国際会議場(愛知県)
Year and Date
2009-09-17
Related Report
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[Presentation] Hyponatremia-Induced Osteoporosis2009
Author(s)
J.Barsony, Sugimura, Y.Manigrasso, H.H.Tam, Q.Xu, Y.Tian, D.Adams, E.A.Carter, H.E.Regnick, J.G.Verbalis
Organizer
8th World Congress on Neurohypoohysial Hormones
Place of Presentation
北九州国際会議場(福岡県)
Year and Date
2009-09-07
Related Report
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