| Project/Area Number |
21500349
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| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
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| Section | 一般 |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OISO Yutaka 名古屋大学, 医学系研究科, 教授 (40203707)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAWADA Makoto 名古屋大学, 環境医学研究所, 教授 (10187297)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | グリア細胞 / レーザーマイクロダイセクション / 脱髄 |
|---|
| Research Abstract |
Osmotic demyelination syndrome(ODS) is a central demyelinating disease associated with a rapid correction of hyponatremia. To clarify the role of microglia in the pathogenesis of ODS, We used laser-capture microdissection to isolate single microglia and analyzed single-microglia gene-expression profiles using high-throughput microarray assays. Our data provide a new insight into the characteristic of microglia associated with injured oligodendrocytes and new molecular targets of minocycline treatment.
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