| Project/Area Number |
21500350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
|
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| Research Institution | University of Miyazaki |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
NEMOTO Takayuki 宮崎大学, 医学部, 助教 (90506833)
WADA Akihiko 宮崎大学, 医学部, 教授 (30131949)
MURAKAMI Manabu 宮崎大学, 医学部, 教授 (80302090)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞内情報伝達 / インスリン受容体シグナル / 神経変性疾患 / 認知症 / 神経保護 / 神経障害 / インスリン受容体 / インスリンシグナリング / インスリン抵抗性 / 発現調節 / 脳・神経 / Glycogen synthase kinase-3β / Insulin receptor substrate |
|---|
| Research Abstract |
Dysregulated insulin receptor signaling(insulin resistance) may be involved in dementia and neurodegenerative disease(e. g. Alzheimer's disease), thus insulin receptor signaling being the major molecular targets of neuroprotective drugs. In the present study, we have demonstrated that the insulin receptor signaling was up-and down-modulated by several therapeutic drugs and bioactive agents(e. g. nicotine, crucmin, docosahexaenoic acid, immunosuppressants and alchol) via multiple intracellular mechanisms.
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