Physiological function of Aβ in regulation of brain cholesterol
| Project/Area Number |
21500352
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
TOMIYAMA Takami 大阪市立大学, 大学院・医学研究科, 准教授 (10305633)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | コレステロール / Aβ / アルツハイマー病 / HDL / ABCA1 / アポリポ蛋白質 / 危険因子 |
|---|
| Research Abstract |
In this study, we found a novel, apolipoprotein-like function of Aβthat mediates cholesterol efflux from cells in cooperation with the membrane cholesterol transporter ABCA1.Aβwas also shown to promote cholesterol transport from the brain into the liver. These findings imply the biological significance of cholesterol-induced Aβproduction and explain why high levels of plasma cholesterol are a risk factor for Alzheimer's disease.
|
Report
(4 results)
Research Products
(13 results)
