| Project/Area Number |
21500354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Showa Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUCHIYA Yukihiro 昭和薬科大学, 薬学部, 助教 (30455406)
NOZAKI Naohito 神奈川歯科大学, 歯学部, 講師 (70222198)
KAMBE Toshie 昭和薬科大学, 薬学部, 講師 (80276625)
MIYAMOTO Yoshiaki 昭和薬科大学, 薬学部, 助教 (20449101)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NOZAKI Naohito 神奈川歯科大学, 歯学部, 講師 (70222198)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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|---|
| Keywords | 細胞内情報伝達 / レドックス / カルモデュリンキナーゼ / グルタチオン化 / 一酸化窒素 / 酸化ストレス |
|---|
| Research Abstract |
Many intracellular signaling events are regulated by Ca^<2+> signals in neurons. It has also been reported that these events are accompanied by generation of reactive oxygen species. Here, we show that oxidation and Ca^<2+> signals are mutual regulated in cells. We propose that oxidation stress might regulate neuronal function via cross-talk with Ca^<2+> signals.
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