| Project/Area Number |
21500359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KASHIWAMURA Shin-ichiro 兵庫医科大学, 医学部, 准教授 (00185761)
NAKAGOMI Takayuki 兵庫医科大学, 医学部, 講師 (80434950)
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| Co-Investigator(Renkei-kenkyūsha) |
TAGUCHI Akihiko (財)先端医療振興財団先端医療センター, 再生医療研究部, 部長 (10359276)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 幹細胞生物学 / 再生 / 修復 / Pericyte |
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| Research Abstract |
In this study, we attributed to explore the characteristics of the induced-neural stem/progenitor cells(iNSPCs) with focusing on the newly generated vascular cells as stem cell niche. We demonstrated that inflammatory cells including lymphocytes affected the post-stroke neurogenesis(J Neurosci Res 2010), and proliferation of iNSPCs was suppressed by endostatin or angiotensin. Bone-marrow derived mononuclear cells(BMMCs) promoted proliferation of endothelial cells with increasing generation of FGF, EGF, IGF and PDGF, suggesting the role on the maintenance of endothelial cells. In addition, BMMCs transplantation increased cerebral blood flow and improved brain function(Stem Cells 2010). Since iNSPCs are originated from the vascular pericytes(Stem Cell Dev 2011) and iNSPCs undergoes apoptosis by the activated lymphocytes(Cell Death Differ 2011), it is hypothesized that iNSPCs are influenced by inflammatory cells. These findings suggest that endothelial cells have an important role on the post-stroke neurogenesis and functional repair.
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