Molecular mechanism for subunit combination of GABAA receptors in adrenal medullary cells
| Project/Area Number |
21500360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
INOUE Masumi 産業医科大学, 医学部, 教授 (40223276)
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| Co-Investigator(Renkei-kenkyūsha) |
HARADA Keita 産業医科大学, 医学部, 助教 (50399200)
MATSUOKA Hidetada 産業医科大学, 医学部, 助教 (90374991)
WARASHINA Akira 産業医科大学, 医学部, 非常勤講師 (50064580)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | シグナル伝達 / 神経科学 / 生理学 / 発現制御 / GABA / 副腎髄質 / Znイオン / GABA_A受容体 / γサブユニット / αサブユニット / Cl電流 / ニューロステロイド / パラクリン / δサブユニット / THIP / GABA_B受容体 / 免疫沈降 |
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| Research Abstract |
GABA produced Cl-currents in dose-dependent manner in guinea-pig adrenal medullary(AM) cells. This GABA dose-response relationship was shifted in the leftward direction with no changes in maximum and Hill's coefficient by allopregnanolone. GABA-induced currents were suppressed by Zn^<2+> and enhanced by flunitrazepam.α3-and γ2-like immunoreactivities were detected at the cell periphery of AM cells.
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Report
(4 results)
Research Products
(27 results)
