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Asymmetric endocytosis across the growth cone that controls axon guidance

Research Project

Project/Area Number 21500361
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

KAMIGUCHI Hiroyuki  独立行政法人理化学研究所, 神経成長機構研究チーム, チームリーダー (10233933)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords軸索 / 成長円錐 / ガイダンス / エンドサイト-シス / エキソサイトーシス / カルシウム / カルシニューリン / サイクリン依存性キナーゼ / エンドサイトーシス / カルシウムイオン / クラスリン / ダイナミン / セマフォリン
Research Abstract

Neuronal circuits are formed by axons that have elongated and reached their targets. The tip of each axon, called the growth cone, explores extracellular guidance cues and can turn in the appropriate direction. In this project, we found that repulsive cues cause asymmetric endocytosis across the growth cone via cytosolic Ca^<2+> signals and that this asymmetric endocytosis is both necessary and sufficient for repulsive guidance. We also showed that a localized imbalance between endocytosis and exocytosis drives growth cone turning.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (13 results) Book (1 results)

  • [Journal Article] Second messengers and membrane trafficking direct and organize growth cone steering2011

    • Author(s)
      Tojima T, Hines JH, Henley JR, Kamiguchi H
    • Journal Title

      Nat Rev Neurosci

      Volume: 12 Pages: 191-203

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance2010

    • Author(s)
      Tojima T, Itofusa R, Kamiguchi H
    • Journal Title

      Neuron

      Volume: 66 Pages: 370-377

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance.2010

    • Author(s)
      Tojima T, Kamiguhi H
    • Journal Title

      Neuron

      Volume: 66 Pages: 370-377

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of neuronal growth cone navigation by asymmetric inositol 1, 4, 5-trisphosphate signals2009

    • Author(s)
      Akiyama H, Matsu-ura T, Mikoshiba K, Kamiguchi H
    • Journal Title

      Sci Signal

      Volume: 2 Pages: 34-34

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The nitric oxide-cGMP pathway controls the directional polarity of growth cone guidance via modulating cytosolic Ca^<2+> signals2009

    • Author(s)
      Tojima T, Itofusa R, Kamiguchi H
    • Journal Title

      J Neurosci

      Volume: 29 Pages: 7886-7897

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The nitric oxide-cyclic GMP pathway controls the directional polarity of growth cone guidance via modulating cytosolic Ca^<2+> signals2009

    • Author(s)
      戸島拓郎
    • Journal Title

      Journal of Neuroscience 29

      Pages: 7886-7897

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of neuronal growth cone navigation by asymmetric inositol 1,4,5-trisphosphate signals2009

    • Author(s)
      秋山博紀
    • Journal Title

      Science Signaling 2

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Growth cone membrane trafficking for axon guidance2012

    • Author(s)
      Kamiguchi H
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology "Membranes in Motion"
    • Place of Presentation
      Tahoe City, USA
    • Year and Date
      2012-01-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経軸索ガイダンスの方向極性を決定するカルシウム依存性エンドサイトーシス2011

    • Author(s)
      戸島拓郎、糸総るり香、上口裕之
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経軸索ガイダンスの方向極性を決定するカルシウム依存性エンドサイトーシス2011

    • Author(s)
      戸島拓郎
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜、日本
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Membrane dynamics in growth cone guidance2011

    • Author(s)
      Kamiguchi H
    • Organizer
      The 8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] The signaling pathway controlling clathrin-mediated endocytosis for bidirectional growth cone guidance2011

    • Author(s)
      Tojima T, Itofusa R, Kamiguchi H
    • Organizer
      The 8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Attractive axon guidance requires phosphatidylinositol 3-kinase-dependnent membrane trafficking in the growth cone2011

    • Author(s)
      Akiyama H, Tojima T, Kamiguchi H
    • Organizer
      The 8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 神経軸索ガイダンスを制御するエンドサイトーシス調節経路: CaMキナーゼIIとカルシニューリンの拮抗作用2011

    • Author(s)
      戸島拓郎、糸総るり香、上口裕之
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 非対称性クラスリン依存性エンドサイトーシスによる成長円錐ガイダンスの駆動機構2010

    • Author(s)
      戸島拓郎、糸総るり香、上口裕之
    • Organizer
      第33回日本神経科学会大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 神経成長円錐ガイダンスにおけるクラスリン依存性エンドサイトーシスの役割2010

    • Author(s)
      戸島拓郎、糸総るり香、上口裕之
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-19
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 成長円錐ガイダンスにおける非対称性膜動態の役割2009

    • Author(s)
      上口裕之
    • Organizer
      神経組織の成長・再生・移植研究会第24回学術集会
    • Place of Presentation
      渋川
    • Year and Date
      2009-06-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 成長円錐局所エンドサイトーシスによる反発性軸索ガイダンス制御2009

    • Author(s)
      戸島拓郎
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 成長円錐ガイダンスにおける非対称性膜動態の役割2009

    • Author(s)
      上口裕之
    • Organizer
      神経組織の成長・再生・移植研究会第24回学術集会
    • Place of Presentation
      群馬県渋川市
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 成長円錐局所エンドサイトーシスによる反発性軸索ガイダンス制御2009

    • Author(s)
      戸島拓郎、糸総るり香、上口裕之
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-03
    • Related Report
      2011 Final Research Report
  • [Book] The driving machinery for growth cone navigation."Cytoskeleton of the Nervous System"2011

    • Author(s)
      Tojima T, Kamiguchi H
    • Publisher
      Springer
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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