| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
We developed a methodology for in vivo administration of neurotransmitter glutamate which mimics glutamates that is released from presynaptic terminals. We found that in adult mouse L2/3 pyramidal neurons, distribution of functional AMPA receptors on spines was proportional to the spine volume. Then we found that repetitive stimulation of a dendritic spine of a living adult mouse caused long-term shrinkage of the spine which lasted 1 hour or more. Thus we could successfully induce long-term plasticity of spine volume, in other words, synaptic plasticity.
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