Development of an in vivo induction method of synaptic plasticity.
Project/Area Number |
21500367
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurophysiology and muscle physiology
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Research Institution | The University of Tokyo |
Principal Investigator |
NOGUCHI Jun 東京大学, 大学院・医学系研究科, 特任助教 (40421367)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | ニューロン / シナプス / 神経回路 / in vivo / 神経科学 / 脳・神経 / シナプス可塑性 |
Research Abstract |
We developed a methodology for in vivo administration of neurotransmitter glutamate which mimics glutamates that is released from presynaptic terminals. We found that in adult mouse L2/3 pyramidal neurons, distribution of functional AMPA receptors on spines was proportional to the spine volume. Then we found that repetitive stimulation of a dendritic spine of a living adult mouse caused long-term shrinkage of the spine which lasted 1 hour or more. Thus we could successfully induce long-term plasticity of spine volume, in other words, synaptic plasticity.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] In vivo two-photon uncaging of glutamate revealing the structure-function relationships o f dendritic spines in the neocortex of adult mice.2011
Author(s)
Noguchi, J., Nagaoka, A., Watanabe, S., Ellis-Davies, G.C.R., Kitamura, K., Kano, M., Matsuzaki, M. & Kasai H.
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Journal Title
J.Physiol.
Volume: 589
Issue: 10
Pages: 2320-2329
DOI
Related Report
Peer Reviewed
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