Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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Research Abstract |
We examined the effect of galanin on synaptic transmission in substantia gelatinosa neurons of rat spinal cord slices by using the patch-clamp technique. Galanin produced a membrane hyperpolarization and facilitated the spontaneous release of L-glutamate. Moreover, galanin inhibited dorsal root evoked excitatory transmission. On the other hand, inhibitory transmission was not affected by galanin. These actions of galanin could contribute to its biphasic regulation of nociceptive transmission.
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