Cellular mechanisms for the biphasic regulation by galanin of nociceptive transmission in the rat spinal dorsal horn
| Project/Area Number |
21500370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Tsugumi 佐賀大学, 医学部, 准教授 (70336139)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | ガラニン / 脊髄後角 / パッチクランプ法 / ラット / 痛覚情報伝達 / 興奮性シナプス伝達 / 抑制性シナプス伝達 / ガラニン受容体 |
|---|
| Research Abstract |
We examined the effect of galanin on synaptic transmission in substantia gelatinosa neurons of rat spinal cord slices by using the patch-clamp technique. Galanin produced a membrane hyperpolarization and facilitated the spontaneous release of L-glutamate. Moreover, galanin inhibited dorsal root evoked excitatory transmission. On the other hand, inhibitory transmission was not affected by galanin. These actions of galanin could contribute to its biphasic regulation of nociceptive transmission.
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Report
(4 results)
Research Products
(212 results)
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[Presentation] TRPA1 but not TRPV1 channels mediate spontaneous excitatory synaptic transmission enhancement produced by zingerone in rat substantia gelatinosa neurons2011
Author(s)
Hai-Yuan Yue, Tsugumi Fujita, Liu Yang, Chang-Yu Jiang, Masanari Inoue, Kotaro Mizuta, Satoko Uemura, Toshiharu Yasaka, Lian-Hua Piao, Hiroshi Hasuo, Eiichi Kumamoto
Organizer
Neuroscience 2011
Place of Presentation
The Walter E. Washington Convention Center(Washington, DC, USA)
Year and Date
2011-11-13
Related Report
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[Presentation] Galanin inhibits dorsal root-evoked monosynaptic glutamatergic excitatory synaptic transmission in adult rat spinal substantia gelationsa neurons2010
Author(s)
Hai-Yuan Yue, Tsugumi Fujita, Masanari Inoue, Chuang-Yu Jiang, Lian-Hua Piao, Tao Liu, Liu Yang, Toshiharu Yasaka, Ting Zou, Shang-Dong Liang, Eiichi Kumamoto
Organizer
The 7th East-West Pain Conference
Place of Presentation
Beijing Convention Center(Beijing, China)
Year and Date
2010-10-11
Related Report
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