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Analysis of the neuronal circuit for learning and memory in the hippocampus: the mechanism of the plasticity at a single mossy fiber synapse

Research Project

Project/Area Number 21500372
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionKobe University (2010-2013)
Dokkyo Medical University (2009)

Principal Investigator

MORI Masahiro  神戸大学, 保健学研究科, 准教授 (60294203)

Project Period (FY) 2009-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords神経科学 / シナプス / 神経回路 / 脳組織培養 / 海馬 / 苔状線維 / 可塑性 / LTP / 記憶・学習 / LTP
Research Abstract

Electrophysiological experiments were performed using the patch-clamp technique to clarify the mechanism of long-term potentiation (LTP) of the synaptic efficacy, a cellular model of learning and memory, at the mossy fiber synapse, the second synapse of the neuronal circuit of the hippocampus, an important brain area for learning and memory. Mossy fiber LTP turned out to be cooperative that simultaneous multiple inputs of the information rather than a single fiber input are required for its induction.

Report

(6 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2014 2013 2012 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) Book (2 results) Remarks (5 results)

  • [Journal Article] Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.2014

    • Author(s)
      Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, Mori M, Takai Y.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 2 Pages: e89763-e89763

    • DOI

      10.1371/journal.pone.0089763

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons2014

    • Author(s)
      Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, Mori M, Takai Y
    • Journal Title

      PLoS One

      Volume: 9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunoglobulin superfamily receptors and adherens junctions.2012

    • Author(s)
      Shimono, Y.
    • Journal Title

      Subcell Biochem.

      Volume: 60 Pages: 137-170

    • DOI

      10.1007/978-94-007-4186-7_7

    • ISBN
      9789400741850, 9789400741867
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity2009

    • Author(s)
      Watt, A. J., Cuntz, H., Mori, M., Nusser, Z., Sjostrom, P. J., Hausser, M.
    • Journal Title

      Nature Neuroscience

      Volume: 12 Pages: 463-473

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity2009

    • Author(s)
      Watt, A.J.
    • Journal Title

      Nature Neuroscience 12

      Pages: 463-473

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] アファディンの海馬神経細胞におけるシナプス形成への関与2013

    • Author(s)
      丸尾知彦, 豊嶋大作, 萬代研二, 富樫英, 井上貴仁, 山本昆明, 三好淳, イルワンスプリヤント, 森正弘, 高井義美
    • Organizer
      Neuro2013(第36回日本神経学大会)
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄運動神経電気シナプスの役割2010

    • Author(s)
      森正弘
    • Organizer
      日本神経科学学会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Electrical coupling between motoneurons in spinal cord2009

    • Author(s)
      森正弘
    • Organizer
      国際生理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-07-31
    • Related Report
      2013 Final Research Report
  • [Presentation] Electrical coupling between motoneurons in spinal cord2009

    • Author(s)
      森正弘
    • Organizer
      国際生理学会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Book] Roles of nectins and nectin-like molecules in the nervous system. In Cell adhesion molecules : implications in neurological diseases, Advances in Neurobiology (Berezin, V. and Walmond, P.S., eds.)2014

    • Author(s)
      Mori, M., Rikitake, Y., Mandai, K., Takai, Y.
    • Publisher
      Springer
    • Related Report
      2013 Final Research Report
  • [Book] Immunoglobulin superfamily receptors and adherens junctions2012

    • Author(s)
      Shimono, Y., Rikitake, Y., Mandai, K., Mori, M., Takai, Y.
    • Publisher
      Subcell Biochem
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/neuron

    • Related Report
      2013 Final Research Report
  • [Remarks] 神戸大学大学院医学研究科 生理学・細胞生物学講座 神経生理学分野

    • URL

      http://www.med.kobe-u.ac.jp/neuron

    • Related Report
      2013 Annual Research Report
  • [Remarks] 神戸大学大学院医学研究科 生理学・細胞生物学講座 神経生理学分野

    • URL

      http://www.med.kobe-u.ac.jp/neuron

    • Related Report
      2012 Annual Research Report
  • [Remarks] 神戸大学大学院医学研究科 生理学・細胞生物学講座 神経生理学分野

    • URL

      http://www.med.kobe-u.ac.jp/neuron

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/neuron

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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