Analysis of the neuronal circuit for learning and memory in the hippocampus: the mechanism of the plasticity at a single mossy fiber synapse

• Project/Area Number: 21500372
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Kobe University (2010-2013); Dokkyo Medical University (2009)
• Principal Investigator: MORI Masahiro 神戸大学, 保健学研究科, 准教授 (60294203)
• Project Period (FY): 2009-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 神経科学 / シナプス / 神経回路 / 脳組織培養 / 海馬 / 苔状線維 / 可塑性 / LTP / 記憶・学習 / ＬＴＰ

Research Abstract

Electrophysiological experiments were performed using the patch-clamp technique to clarify the mechanism of long-term potentiation (LTP) of the synaptic efficacy, a cellular model of learning and memory, at the mossy fiber synapse, the second synapse of the neuronal circuit of the hippocampus, an important brain area for learning and memory. Mossy fiber LTP turned out to be cooperative that simultaneous multiple inputs of the information rather than a single fiber input are required for its induction.

Research Products

• [Journal Article] Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons. (2014)
  • Author(s): Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, Mori M, Takai Y.
  • Journal Title: PLoS One. Volume: 9 Issue: 2 Pages: e89763-e89763
  • DOI: 10.1371/journal.pone.0089763
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons (2014)
  • Author(s): Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, Mori M, Takai Y
  • Journal Title: PLoS One Volume: ９
  • Peer Reviewed
• [Journal Article] Immunoglobulin superfamily receptors and adherens junctions. (2012)
  • Author(s): Shimono, Y.
  • Journal Title: Subcell Biochem. Volume: 60 Pages: 137-170
  • DOI: 10.1007/978-94-007-4186-7_7
  • ISBN: 9789400741850, 9789400741867
  • Peer Reviewed
• [Journal Article] Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity (2009)
  • Author(s): Watt, A. J., Cuntz, H., Mori, M., Nusser, Z., Sjostrom, P. J., Hausser, M.
  • Journal Title: Nature Neuroscience Volume: 12 Pages: 463-473
  • Peer Reviewed
• [Journal Article] Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity (2009)
  • Author(s): Watt, A.J.
  • Journal Title: Nature Neuroscience 12 Pages: 463-473
  • Peer Reviewed
• [Presentation] アファディンの海馬神経細胞におけるシナプス形成への関与 (2013)
  • Author(s): 丸尾知彦, 豊嶋大作, 萬代研二, 富樫英, 井上貴仁, 山本昆明, 三好淳, イルワンスプリヤント, 森正弘, 高井義美
  • Organizer: Neuro2013(第36回日本神経学大会)
  • Place of Presentation: 京都
• [Presentation] 脊髄運動神経電気シナプスの役割 (2010)
  • Author(s): 森正弘
  • Organizer: 日本神経科学学会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-09-02
• [Presentation] Electrical coupling between motoneurons in spinal cord (2009)
  • Author(s): 森正弘
  • Organizer: 国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-31
• [Presentation] Electrical coupling between motoneurons in spinal cord (2009)
  • Author(s): 森正弘
  • Organizer: 国際生理学会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2009-07-31
• [Book] Roles of nectins and nectin-like molecules in the nervous system. In Cell adhesion molecules : implications in neurological diseases, Advances in Neurobiology (Berezin, V. and Walmond, P.S., eds.) (2014)
  • Author(s): Mori, M., Rikitake, Y., Mandai, K., Takai, Y.
  • Publisher: Springer
• [Book] Immunoglobulin superfamily receptors and adherens junctions (2012)
  • Author(s): Shimono, Y., Rikitake, Y., Mandai, K., Mori, M., Takai, Y.
  • Publisher: Subcell Biochem
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/neuron
• [Remarks] 神戸大学大学院医学研究科 生理学・細胞生物学講座 神経生理学分野
  • URL: http://www.med.kobe-u.ac.jp/neuron
• [Remarks] 神戸大学大学院医学研究科 生理学・細胞生物学講座 神経生理学分野
  • URL: http://www.med.kobe-u.ac.jp/neuron
• [Remarks] 神戸大学大学院医学研究科 生理学・細胞生物学講座 神経生理学分野
  • URL: http://www.med.kobe-u.ac.jp/neuron
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/neuron