Analysis of dynamic interaction between dopamine receptors and calcium channels located on the synaptic terminals in the basal forebrain
| Project/Area Number |
21500374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 前脳基底核 / シナプス / ドーパミン受容体 / カルシウムチャネル / パッチクランプ / カーボンナノチューブ / スライス / 生後発達変化 / ドーパミン / 伝達物質遊離 / ラット / 中脳 |
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| Research Abstract |
The present electrophysiological study has clarified a developmental increase in dopamine D1-like receptor-mediated inhibition of glutamatergic transmission onto cholinergic neurons in the rat basal forebrain through adenylyl cyclase and P/Q-type calcium channel regulation.
The present electrochemical study, introducing a new biosensor material, carbon nanotube, has succeeded in the detection of physiologically released dopamine as a redox current in brain slice preparation. Furthermore, the present study has established a method for simultaneous recordings of dopamine release and membrane potential, thereby clarifying that activation of D2-like receptors reduces dopamine release by hyperpolarizing the membrane of dopaminergic neurons.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake2011
Author(s)
Mitsumori T., Furuyashihki T., Momiyama T., Nishi A., Shuto T., Hayakawa T., Ushikubi F., Kitaoka S., Aoki T., Inoue H., Matsuoka T. & Narumiya S.
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Journal Title
European Journal of Neuroscience
Volume: 34
Issue: 4
Pages: 594-604
DOI
Related Report
Peer Reviewed
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[Journal Article] Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine revel in the dorsal striatum2009
Author(s)
Tanaka Y., Furuyashiki T., Momiyama T., Namba H., Mizoguchi A., Mitsumori T., Kayahara T., Shichi H., Kimura K., Matsuoka T., Nawa H. & Narumiya S.
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Journal Title
European Journal of Neuroscience
Volume: 30
Issue: 12
Pages: 2338-2346
DOI
Related Report
Peer Reviewed
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