Investigation of visual awareness and its neural mechanism using a macaque model of blindsight

• Project/Area Number: 21500377
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: YOSHIDA Masatohi 生理学研究所, 発達生理学研究系, 助教 (30370133)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 膝状体外経路 / 空間的注意 / 視覚意識 / 急速眼球運動 / 盲視 / 残存視力

Research Abstract

The aim of this study is to elucidate the neural mechanism of visual awareness using animal model of blindsight. We recorded the neural activities of the superior colliculus of the monkeys and found that their visual response is stronger when the monkeys were able to detect visual stimuli that when they failed to it. We found that such activity was developed during the transmission of visual information through the superficial layer of the superior colliculus to the intermediate later of the superior colliculus. These findings suggest that neural correlate of visual awareness develops within the local circuit of the superior colliculus.

Research Products

• [Journal Article] Residual attention guidance in blindsightmonkeys watching complex natural scenes (2012)
  • Author(s): Yoshida M, Itti L, Berg DJ, Ikeda T, Kato R, Takaura K, White BJ, Munoz DP, Isa T.
  • Journal Title: Curr Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Contribution of the retino-tectal pathway to visually guided saccades after lesion of the primary visual cortex in monkeys (2012)
  • Author(s): Kato R, Ikeda T, Takaura K, Yoshida M, Isa T.
  • Journal Title: Eur J Neurosci Volume: 33 Pages: 1952-1960
  • Peer Reviewed
• [Journal Article] Neural substrate of spatial memory in the superior colliculus after damage to the primary visual cortex (2011)
  • Author(s): Takaura K, Yoshida M, Isa T.
  • Journal Title: J Neurosci Volume: 31 Pages: 4233-4241
  • Peer Reviewed
• [Journal Article] Lesion of primary visual cortex in monkey impairs the inhibitory but not the facilitatory cueing effect on saccade (2011)
  • Author(s): Ikeda T, Yoshida M, Isa T.
  • Journal Title: J Cogn Neurosci Volume: 23 Pages: 1160-1169
  • Peer Reviewed
• [Journal Article] Neural substrate of spatial memory in the superior colliculus after damage to the primary visual cortex (2011)
  • Author(s): 高浦加奈、吉田正俊、伊佐正
  • Journal Title: The Journal of Neuroscience Volume: 31(11) Issue: 11 Pages: 4233-4241
  • DOI: 10.1523/jneurosci.5143-10.2011
  • Peer Reviewed
• [Journal Article] Contribution of the retino-tectal pathway to visually guided saccades after lesion of the primary visual cortex in monkeys (2011)
  • Author(s): 加藤利佳子、高浦加奈、池田琢朗、吉田正俊、伊佐正
  • Journal Title: The European journal of neuroscience Volume: 33(11) Issue: 11 Pages: 1952-1960
  • DOI: 10.1111/j.1460-9568.2011.07729.x
  • Peer Reviewed
• [Journal Article] Contribution of the retino-tectal pathway to visually guided saccades after lesion of the primary visual cortex in monkeys (2011)
  • Author(s): 加藤利佳子、池田琢朗、高浦加奈、吉田正俊、伊佐正
  • Journal Title: European Journal of Neuroscience Volume: In press
  • Peer Reviewed
• [Journal Article] Neural substrate of spatial memory in the superior colliculus after damage to the primary visual cortex. (2011)
  • Author(s): 高浦加奈、吉田正俊、伊佐正
  • Journal Title: Journal of Neuroscience Volume: 31 Pages: 4233-4241
  • Peer Reviewed
• [Journal Article] Lesion of primary visual cortex in monkey impairs the inhibitory but not the facilitatory cueing effect on saccade. (2011)
  • Author(s): 池田琢朗、吉田正俊、伊佐正
  • Journal Title: Journal of Cognitive Neuroscience Volume: 23 Pages: 1160-1169
  • Peer Reviewed
• [Journal Article] Saccade control after V1 lesion revisited (2009)
  • Author(s): 伊佐正、吉田正俊
  • Journal Title: Current Opinion in Neurobiology 19(6) Pages: 608-614
  • Peer Reviewed
• [Journal Article] 見えないのにわかる-「盲視」の脳内メカニズム (2009)
  • Author(s): 吉田正俊
  • Journal Title: 日本眼光学学会誌視覚の科学 30(4) Pages: 109-114
  • NAID: 10026393241
• [Presentation] Express saccade without V1 (2011)
  • Author(s): 吉田正俊
  • Organizer: Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-14
• [Presentation] エクスプレスサッカードに第一次視覚野は必須ではない (2011)
  • Author(s): 吉田正俊
  • Organizer: 日本神経科学大会
  • Place of Presentation: 横浜パシフィコ(神奈川県)
  • Year and Date: 2011-09-13
• [Presentation] Neural information processing in the superior colliculus of blindsight monkey (2011)
  • Author(s): 吉田正俊
  • Organizer: Association for Scientific Study of Consciousness(ASSC15) Satellite symposium "Neurophysiology of Attention and Awareness"
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2011-06-13
• [Presentation] Neural information processing in the superior colliculus of blindsight monkey (2011)
  • Author(s): 吉田正俊
  • Organizer: Association for Scientific Study of Consciousness (ASSC15) Satellite symposium "Neurophysiology of Attention and Awareness"
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2011-06-13
• [Presentation] Neural correlate of blindsight generated within the superior colliculus (2011)
  • Author(s): 吉田正俊
  • Organizer: Association for Scientific Study of Consciousness (ASSC15)
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2011-06-12
• [Presentation] Guidance of gaze based on color saliency in monkeys with blindsight (2010)
  • Author(s): 吉田正俊
  • Organizer: 第14回意識の科学的研究学会大会
  • Place of Presentation: Chestnut(カナダ)
  • Year and Date: 2010-06-24
• [Presentation] Guidance of gaze based on color saliency in monkeys with blindsight (2010)
  • Author(s): 吉田正俊
  • Organizer: 第14回意識の科学的研究学会大会
  • Place of Presentation: 89 Chestnut(カナダ)
  • Year and Date: 2010-06-24
• [Presentation] 盲視サルにおける気づきと意思決定 (2009)
  • Author(s): 吉田正俊
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-18
• [Presentation] Awareness and Decision in Monkey with Blindsight (2009)
  • Author(s): 吉田正俊
  • Organizer: 第13回意識の科学的研究学会大会
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2009-06-06
• [Presentation] Neural correlate of awareness in monkey with blindsight (2009)
  • Author(s): 吉田正俊
  • Organizer: 第24回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール(石川県)
  • Year and Date: 2009-05-29
• [Presentation] Neural correlate of awareness in monkey with blindsight (2009)
  • Author(s): 吉田正俊
  • Organizer: 第24回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール
  • Year and Date: 2009-05-29
• [Book] Advances in Cognitive Neurodynamics(III) (2012)
  • Author(s): 吉田正俊
  • Publisher: Springer
• [Book] Advances in Cognitive Neurodynamics (III)(一部担当) (2012)
  • Author(s): 吉田正俊
  • Total Pages: 600
  • Publisher: Springer
• [Remarks]
  • URL: http://www.nips.ac.jp/%7Emyoshi/
• [Remarks]
  • URL: http://researchmap.jp/masatoshiyoshida/
• [Remarks]
  • URL: http://www.nips.ac.jp/%7Emyoshi/
• [Remarks]
  • URL: http://researchmap.jp/masatoshiyoshida/
• [Remarks]
  • URL: http://www.nips.ac.jp/%7Emyoshi/
• [Remarks]
  • URL: http://researchmap.jp/masatoshiyoshida/
• [Remarks]
  • URL: http://www.nips.ac.jp/%7Emyoshi/